Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Cecelia L, Green"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2322 (2024)
Fibrosis is a chronic pathology resulting from excessive deposition of extracellular matrix components that leads to the loss of tissue function. Pulmonary fibrosis can follow a variety of diverse insults including ischemia, respiratory infection, or
Externí odkaz:
https://doaj.org/article/c3e1af6bff26482593221ec4a71930e1
Autor:
Lynn W. Maines, Randy S. Schrecengost, Yan Zhuang, Staci N. Keller, Ryan A. Smith, Cecelia L. Green, Charles D. Smith
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13191 (2022)
Exposure to ionizing radiation (IR) is a lingering threat from accidental or terroristic nuclear events, but is also widely used in cancer therapy. In both cases, host inflammatory responses to IR damage normal tissue causing morbidity and possibly m
Externí odkaz:
https://doaj.org/article/0ae24166724c41b99c92ef7419c8a8fe
Publikováno v:
International Journal of Nephrology and Renovascular Disease.
Lynn W Maines, Cecelia L Green, Staci N Keller, Leo R Fitzpatrick, Charles D Smith Apogee Biotechnology Corporation, Hummelstown, PA, USACorrespondence: Charles D Smith, Apogee Biotechnology Corporation, 1214 Research Blvd, Suite 2015, Hummelstown, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fc73c8de31a9d3cd2c971db33a66d2
https://www.dovepress.com/the-sphingosine-kinase-2-inhibitor-opaganib-protects-against-acute-kid-peer-reviewed-fulltext-article-IJNRD
https://www.dovepress.com/the-sphingosine-kinase-2-inhibitor-opaganib-protects-against-acute-kid-peer-reviewed-fulltext-article-IJNRD
Autor:
Randy S. Schrecengost, Ryan A. Smith, Staci N. Keller, Cecelia L. Green, Charles D. Smith, Lynn W. Maines, Yan Zhuang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:107-116
Glycogen synthase kinase-3s (GSK3α and GSK3β) are constitutively active protein kinases that target over 100 substrates, incorporate into numerous protein complexes, and regulate such vital cellular functions as proliferation, apoptosis, and inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5895fb458b6fac8e07fe077ca0be280e
https://doi.org/10.1124/jpet.117.245738
https://doi.org/10.1124/jpet.117.245738
Publikováno v:
Pharmacology. 87:135-143
Background/Aims: Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation and chondrocyte apoptosis, which may involve aberrant sphingolipid metabolism. ABC294640 is a compound that selectively inhibits sphingo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e74f909a709d21d14243eef2e41570
https://doi.org/10.1159/000323911
https://doi.org/10.1159/000323911
Publikováno v:
Inflammopharmacology. 18:73-85
Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn’s disease. Trinitrobenzen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac051dee7e26dcf3d032aac77c6f3250
https://doi.org/10.1007/s10787-010-0032-x
https://doi.org/10.1007/s10787-010-0032-x
Autor:
Cecelia L. Green, Charles D. Smith, Lynn W. Maines, Yan Zhuang, Ryan A. Smith, Staci N. Keller, Randy S. Schrecengost
Publikováno v:
Molecular Cancer Therapeutics. 17:B190-B190
Background: Several established chemotherapy drugs, including vinca alkaloids and paclitaxel, block tumor cell division by disrupting microtubule dynamics, ultimately leading to apoptosis. For decades, these drugs have remained central components for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29e709d8cd3816a8254ef4e7e05d9806
https://doi.org/10.1158/1535-7163.targ-17-b190
https://doi.org/10.1158/1535-7163.targ-17-b190
Autor:
Jon Korostoff, Edward T. Lally, Joel Rosenbloom, Martyn K. Robinson, Cecelia L. Green, Bruce J. Shenker, Susan Ortlepp, Jian Fei Wang, Paul C. Billings, Irene R. Kieba, Atsushi Sato
Publikováno v:
Journal of Biological Chemistry. 272:30463-30469
Actinobacillus actinomycetemcomitans leukotoxin and Escherichia coli alpha-hemolysin are RTX toxins that kill human immune cells. We have obtained a monoclonal antibody (295) to a cell surface molecule present on toxin-sensitive HL60 cells that can i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc75a29f0a8791e6da4a14b16138b2da
https://doi.org/10.1074/jbc.272.48.30463
https://doi.org/10.1074/jbc.272.48.30463
Autor:
Cecelia L. Green, Staci N. Keller, Kevin J. French, Vladimir Beljanski, Yan Zhuang, John J. Upson, Charles D. Smith, Peng Gao, Wenxue Wang, Lynn W. Maines
Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of important bioactive lipids, including the apoptotic compound ceramide and the proliferative compound sphingosine 1-phosphate (S1P). Many growth factors and inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9179ae3d28df0a8fcd9474821e5740b7
https://europepmc.org/articles/PMC2846016/
https://europepmc.org/articles/PMC2846016/
Publikováno v:
The Journal of surgical research. 144(1)
Background The claudins are tight junction (TJ) proteins. Claudin-2 has been found to negatively affect the TJ, causing a decrease in transepithelial resistance. Patients with inflammatory bowel disease have altered intestinal permeability, suggestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea25da18adb57d7c991465b7ca1c899b
https://pubmed.ncbi.nlm.nih.gov/17640674
https://pubmed.ncbi.nlm.nih.gov/17640674