Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Cecelia D. Trainor"'
Autor:
Masahiro Nakamura, Ritsuko Shimizu, Cecelia D. Trainor, Atsushi Hasegawa, Daishi Ishihara, Masayuki Yamamoto, Akira Watanabe, Hiroshi Kaneko
GATA1 organizes erythroid and megakaryocytic differentiation by orchestrating the expression of multiple genes that show diversified expression profiles. Here, we demonstrate that GATA1 monovalently binds to a single GATA motif (Single-GATA) while a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f6248bdf8395931d93450176bb0f9b
https://europepmc.org/articles/PMC4968217/
https://europepmc.org/articles/PMC4968217/
Autor:
Ivan Bièche, Dani Fallin, Chantal Lotton, Diana Zelenika, Paul-Henri Romeo, Emanuele Miraglia del Giudice, Virginie Mariot, Ingrid Laurendeau, Mark Lathrop, Cecelia D. Trainor, David Meyre, Catherine Le Stunff, Pierre Bougnères, Philippe Froguel, Agnès Dechartres
Publikováno v:
Diabetes. 57:494-502
OBJECTIVE—In search of functional polymorphisms associated with the genetics of insulin resistance, we studied a variant in the promoter of PIK3CB, the gene coding for the catalytic p110β subunit of phosphatidylinositol (PI) 3-kinase, a major effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471b8fd2c135a8d4721433e516531ebf
https://doi.org/10.2337/db07-1273
https://doi.org/10.2337/db07-1273
Publikováno v:
The FASEB Journal. 29
Centromere-associated protein E (CENP-E) is an integral component of the kinetochore, and has been shown to be essential for chromosome congression during mitosis. However, the molecular mechanism ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f0924dc70f94c2717b93e5b4218e2eb
https://doi.org/10.1096/fasebj.29.1_supplement.709.6
https://doi.org/10.1096/fasebj.29.1_supplement.709.6
Publikováno v:
Blood. 103:2560-2567
Association of GATA-1 and its cofactor Friend of GATA-1 (FOG-1) is essential for erythroid and megakaryocyte development. To assess functions of GATA-1–FOG-1 association during mouse development, we used the GATA-1 hematopoietic regulatory domain t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f032a9889870ccfedf72644350d44108
https://doi.org/10.1182/blood-2003-07-2514
https://doi.org/10.1182/blood-2003-07-2514
Autor:
Cecelia D. Trainor, Rodolfo Ghirlando
Publikováno v:
Journal of Biological Chemistry. 278:45620-45628
Mammalian GATA transcription factors are expressed in various tissues in a temporally regulated manner. The prototypic member, GATA-1, is required for normal erythroid, megakaryocytic, and mast cell development. This family of DNA-binding proteins re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23744ff4bc4d41a70e4861594ad3dc3f
https://doi.org/10.1074/jbc.m306410200
https://doi.org/10.1074/jbc.m306410200
Publikováno v:
Journal of Biological Chemistry. 277:18313-18321
Using a transgenic approach, we studied the role of GATA-3 in T cells. As previously shown, enforced GATA-3 expression in transgenic mice inhibits Th1 differentiation of CD4 T cells, but unexpectedly, both type 1 (interferon γ) and type 2 (interleuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3acb36aef1e84556a6ea6731fb0b0b4
https://doi.org/10.1074/jbc.m110013200
https://doi.org/10.1074/jbc.m110013200
Autor:
Rodolfo Ghirlando, Cecelia D. Trainor
Publikováno v:
Journal of Biological Chemistry. 275:28152-28156
The DNA binding domain of GATA-1 consists of two adjacent homologous zinc fingers, of which only the C-terminal finger binds DNA independently. Solution structure studies have shown that the DNA is bent by about 15 degrees in the complex formed with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0572eac93be9c30a6fa16747532b37a8
https://doi.org/10.1074/jbc.m002053200
https://doi.org/10.1074/jbc.m002053200
Publikováno v:
Molecular Endocrinology. 9:1135-1146
GATA-1 is a DNA-binding protein that regulates transcription of erythroid-specific genes and is required for the formation of mature erythroid cells. We show here that the GATA-1 hormone response-like element (GHRE) within the first intron of the gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efc884fbb6ad0953319077a35f24c8a
https://doi.org/10.1210/mend.9.9.7491106
https://doi.org/10.1210/mend.9.9.7491106
Autor:
Wulin Aerbajinai, Peter Gao, Jianqiong Zhu, Kyung Chin, Griffin P. Rodgers, Cecelia D. Trainor
The β-hemoglobinopathies sickle cell disease and β-thalassemia are among the most common human genetic disorders worldwide. Hemoglobin A2 (HbA2, α2δ2) and fetal hemoglobin (HbF, α2γ2) both inhibit the polymerization of hemoglobin S, which resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c7e211f935fa09517a976e6170b1bc
https://europepmc.org/articles/PMC3062308/
https://europepmc.org/articles/PMC3062308/
Autor:
Gary Felsenfeld, Todd Evans, G M Clore, Angela M. Gronenborn, James G. Omichinski, Cecelia D. Trainor
Publikováno v:
Proceedings of the National Academy of Sciences. 90:1676-1680
Sequence-specific DNA binding has been demonstrated for a synthetic peptide comprising only one of the two "finger"-like domains of the erythroid transcription factor GATA-1 (also termed Eryf-1, NF-E1, or GF-1). Quantitative analysis of gel-retardati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86992b1f4e5744e6905a3d1fec43c6e9
https://doi.org/10.1073/pnas.90.5.1676
https://doi.org/10.1073/pnas.90.5.1676