Zobrazeno 1 - 10
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pro vyhledávání: '"Ceccarelli, DF"'
Autor:
Zeqiraj, E, Tian, L, Piggott, CA, Pillon, MC, Duffy, NM, Ceccarelli, DF, Keszei, AFA, Lorenzen, K, Kurinov, I, Orlicky, S, Gish, GD, Heck, AJR, Guarné, A, Greenberg, RA, Sicheri, F
Publikováno v:
Molecular cell
BRCC36 is a Zn2+-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition. The MPN+ domain protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f4209008d8b50e283ee22b87f3366259
https://eprints.whiterose.ac.uk/127916/8/1-s2.0-S1097276515005869-main.pdf
https://eprints.whiterose.ac.uk/127916/8/1-s2.0-S1097276515005869-main.pdf
Akademický článek
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Autor:
Koszela J; School of Molecular Biosciences, University of Glasgow, Glasgow G12 8QQ, U.K., Pham NT; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; College of Medicine and Veterinary Medicine, Institute for Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, U.K., Shave S; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, U.K., St-Cyr D; X-Chem Inc., Montréal, Québec H4S 1Z9, Canada.; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Ceccarelli DF; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Orlicky S; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Marinier A; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Sicheri F; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Tyers M; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Auer M; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.
Publikováno v:
Bioconjugate chemistry [Bioconjug Chem] 2024 Sep 18; Vol. 35 (9), pp. 1441-1449. Date of Electronic Publication: 2024 Aug 21.
Autor:
Barbulescu P; Department of Immunology, University of Toronto, Toronto, ON, Canada., Chana CK; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Wong MK; Department of Immunology, University of Toronto, Toronto, ON, Canada., Ben Makhlouf I; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Bruce JP; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Feng Y; Department of Immunology, University of Toronto, Toronto, ON, Canada., Keszei AFA; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Wong C; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Department of Chemistry, Wayne State University, Detroit, MI, USA., Mohamad-Ramshan R; Department of Chemistry, Wayne State University, Detroit, MI, USA., McGary LC; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Department of Chemistry, Wayne State University, Detroit, MI, USA., Kashem MA; Department of Immunology, University of Toronto, Toronto, ON, Canada., Ceccarelli DF; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Orlicky S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Fang Y; Department of Immunology, University of Toronto, Toronto, ON, Canada., Kuang H; Cryo-Electron Microscopy Core, New York University School of Medicine, New York, NY, USA., Mazhab-Jafari M; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Pezo RC; Sunnybrook Health Sciences Center, Toronto, ON, Canada., Bhagwat AS; Department of Chemistry, Wayne State University, Detroit, MI, USA., Pugh TJ; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Sicheri F; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca., Martin A; Department of Immunology, University of Toronto, Toronto, ON, Canada. alberto.martin@utoronto.ca.
Publikováno v:
Nature communications [Nat Commun] 2024 Aug 30; Vol. 15 (1), pp. 7541. Date of Electronic Publication: 2024 Aug 30.
Autor:
Chana CK; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Maisonneuve P; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Posternak G; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Grinberg NGA; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Poirson J; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Ona SM; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Ceccarelli DF; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Mader P; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., St-Cyr DJ; X-Chem Inc., Montréal, Québec H4S 1Z9, Canada., Pau V; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, Illinois 60439, United States., Tang X; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada., Deng D; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Cui W; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Su W; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Kuai L; WuXi AppTec, 55 Cambridge Parkway, 8th Floor, Cambridge, Massachusetts 02142, United States., Soll R; WuXi AppTec, 55 Cambridge Parkway, 8th Floor, Cambridge, Massachusetts 02142, United States., Tyers M; Institute for Research in Immunology and Cancer, University of Montréal, Québec H3C 3J7, Canada., Röst HL; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 2E4, Canada., Batey RA; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada., Taipale M; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario M5G 1X5, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2022 Oct 13; Vol. 65 (19), pp. 12725-12746. Date of Electronic Publication: 2022 Sep 18.
Autor:
St-Cyr D; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Ceccarelli DF; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Orlicky S; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., van der Sloot AM; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Tang X; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Kelso S; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Moore S; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., James C; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Posternak G; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Coulombe-Huntington J; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Bertomeu T; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Marinier A; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.; Department of Chemistry, University of Montreal, Montreal, Québec H3C 3J7, Canada., Sicheri F; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Tyers M; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.; Department of Medicine, University of Montreal, Montreal, Québec H3C 3J7, Canada.
Publikováno v:
Science advances [Sci Adv] 2021 Oct 29; Vol. 7 (44), pp. eabi5797. Date of Electronic Publication: 2021 Oct 27.
Autor:
Kelso S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada., Orlicky S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada., Beenstock J; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada., Ceccarelli DF; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada., Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, IL 60439, USA., Gish G; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada; Department of Biochemistry, University of Toronto, ON M5S 1A8, Canada. Electronic address: sicheri@lunenfeld.ca.
Publikováno v:
Structure (London, England : 1993) [Structure] 2021 Sep 02; Vol. 29 (9), pp. 975-988.e5. Date of Electronic Publication: 2021 May 13.
Autor:
Beenstock J; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Ona SM; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Porat J; Department of Biology, York University, Toronto, ON, Canada., Orlicky S; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Wan LCK; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Ceccarelli DF; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Maisonneuve P; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Szilard RK; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Yin Z; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Setiaputra D; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Mao DYL; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Khan M; Department of Chemistry, University of Calgary, Calgary, AB, Canada., Raval S; Department of Chemistry, University of Calgary, Calgary, AB, Canada., Schriemer DC; Department of Chemistry, University of Calgary, Calgary, AB, Canada.; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada., Bayfield MA; Department of Biology, York University, Toronto, ON, Canada., Durocher D; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Sicheri F; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.
Publikováno v:
Nature communications [Nat Commun] 2020 Dec 04; Vol. 11 (1), pp. 6233. Date of Electronic Publication: 2020 Dec 04.
Autor:
Posternak G; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Tang X; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Maisonneuve P; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Jin T; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Quebec, Montreal, Canada., Lavoie H; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Quebec, Montreal, Canada., Daou S; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Orlicky S; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Goullet de Rugy T; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Caldwell L; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Chan K; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Prakesch M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Mader P; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Wong C; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Maier S; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Kitaygorodsky J; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Larsen B; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Colwill K; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Yin Z; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Ceccarelli DF; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Batey RA; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Taipale M; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada., Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, IL, USA., Uehling D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Wrana J; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Durocher D; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Gingras AC; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Therrien M; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Quebec, Montreal, Canada. marc.therrien@umontreal.ca.; Département de Pathologie et Biologie Cellulaire, University of Montréal, Quebec, Montreal, Canada. marc.therrien@umontreal.ca., Sicheri F; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada. sicheri@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. sicheri@lunenfeld.ca.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. sicheri@lunenfeld.ca.
Publikováno v:
Nature chemical biology [Nat Chem Biol] 2020 Nov; Vol. 16 (11), pp. 1170-1178. Date of Electronic Publication: 2020 Aug 10.
Autor:
Garg P; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada., Ceccarelli DF; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada., Keszei AFA; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada., Kurinov I; Department of Chemistry and Chemical Biology, NE-CAT, Cornell University, Argonne, IL 60439, USA., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. Electronic address: sicheri@lunenfeld.ca., Sidhu SS; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada. Electronic address: sachdev.sidhu@utoronto.ca.
Publikováno v:
Journal of molecular biology [J Mol Biol] 2020 Feb 14; Vol. 432 (4), pp. 952-966. Date of Electronic Publication: 2019 Oct 19.