Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cecília M.P. Rodrigues"'
Autor:
Jacinta O. Pinho, Mariana Matias, Vanda Marques, Carla Eleutério, Célia Fernandes, Lurdes Gano, Joana D. Amaral, Eduarda Mendes, Maria Jesus Perry, João Nuno Moreira, Gert Storm, Ana Paula Francisco, Cecília M.P. Rodrigues, M. Manuela Gaspar
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114021- (2023)
The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifical
Externí odkaz:
https://doaj.org/article/8bcb887236f344f381f68daa3c7e19f5
Autor:
Celso Alves, Joana Silva, Marta B. Afonso, Romina A. Guedes, Rita C. Guedes, Rebeca Alvariño, Susete Pinteus, Helena Gaspar, Márcia I. Goettert, Amparo Alfonso, Cecília M.P. Rodrigues, Maria C. Alpoím, Luis Botana, Rui Pedrosa
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 149, Iss , Pp 112886- (2022)
Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1–100 µM; 24 h) were
Externí odkaz:
https://doaj.org/article/3ff4288ac7fe407ead4d670ab4f710eb
Autor:
André A. Santos, Marta B. Afonso, Ricardo S. Ramiro, David Pires, Madalena Pimentel, Rui E. Castro, Cecília M.P. Rodrigues
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
New evidence shows that host-microbiota crosstalk can be modulated via endogenous miRNAs. We have previously reported that miR-21 ablation protects against liver injury in cholestasis. In this study, we investigated the role of miR-21 in modulating t
Externí odkaz:
https://doaj.org/article/034712df79aa42139becdb9f3f8a2063
Autor:
Vasco Branco, Lucia Coppo, Susana Solá, Jun Lu, Cecília M.P. Rodrigues, Arne Holmgren, Cristina Carvalho
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 278-287 (2017)
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely target
Externí odkaz:
https://doaj.org/article/e71866dab99747579be1e4fdb45a6ee6
Autor:
Tânia Sousa, Rui E. Castro, Sandra N. Pinto, Ana Coutinho, Susana D. Lucas, Rui Moreira, Cecília M.P. Rodrigues, Manuel Prieto, Fábio Fernandes
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2158-2171 (2015)
Cytotoxic bile acids, such as deoxycholic acid (DCA), are responsible for hepatocyte cell death during intrahepatic cholestasis. The mechanisms responsible for this effect are unclear, and recent studies conflict, pointing to either a modulation of p
Externí odkaz:
https://doaj.org/article/bfc6a06e23dd4e5ebe5e867e36df92e9
Publikováno v:
Neurobiology of Disease, Vol 50, Iss , Pp 21-29 (2013)
Alzheimer's disease (AD) is a neurodegenerative disease hallmarked by extracellular Aβ1–42 containing plaques, and intracellular neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein. Progressively, memory deficits and cognitive
Externí odkaz:
https://doaj.org/article/ced33af434a447ab84c678b242296a58
Autor:
Joana D. Amaral, Ricardo J.S. Viana, Rita M. Ramalho, Clifford J. Steer, Cecília M.P. Rodrigues
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1721-1734 (2009)
Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several
Externí odkaz:
https://doaj.org/article/74b78e9f01d243969354f043629798fe
Autor:
Cecília M.P. Rodrigues, Susana Solá, Rui E. Castro, Pedro A. Laires, Dora Brites, José J.G. Moura
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 6, Pp 885-894 (2002)
Increased levels of unconjugated bilirubin, the end product of heme catabolism, impair crucial aspects of nerve cell function. In previous studies, we demonstrated that bilirubin toxicity may be due to cell death by apoptosis. To characterize the seq
Externí odkaz:
https://doaj.org/article/5b415f54bce844b2acc0c9d50a07cd30
Autor:
Jacinta O. Pinho, Mariana Matias, Ana Godinho-Santos, Joana D. Amaral, Eduarda Mendes, Maria Jesus Perry, Ana Paula Francisco, Cecília M.P. Rodrigues, M. Manuela Gaspar
Publikováno v:
International Journal of Pharmaceutics. 640:123011
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::241ab7115df86ed77efdad33441863c0
https://doi.org/10.1016/j.ijpharm.2023.123011
https://doi.org/10.1016/j.ijpharm.2023.123011
Autor:
Jacinta O. Pinho, Mariana Matias, Vanda Marques, Carla Eleutério, Célia Fernandes, Lurdes Gano, Joana D. Amaral, Eduarda Mendes, Maria Jesus Perry, João Nuno Moreira, Gert Storm, Ana Paula Francisco, Cecília M.P. Rodrigues, M. Manuela Gaspar
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 157
The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2929ee5d4512b6043d3c56cd1697be74
https://pubmed.ncbi.nlm.nih.gov/36399831
https://pubmed.ncbi.nlm.nih.gov/36399831