Výsledky vyhledávání - "Cecília M S Q, Aranha"

Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H

Autor: Cecília M S Q, Aranha, David, Reiner-Link, Luisa R, Leitzbach, Flavia B, Lopes, Holger, Stark, João Paulo S, Fernandes

Publikováno v: Bioorganicmedicinal chemistry. 78

Multitargeting ligands on enzymes and receptors may generate a profile for a potential treatment of cognitive impairment. Considering this, a set of 21 substituted aryl-alkyl-piperazines were designed, prepared and tested for their binding affinities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::035cdeac91f4fa0ca3ac42e50d8abf47
https://pubmed.ncbi.nlm.nih.gov/36542960

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Histamine H 3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands

Autor: João Paulo S. Fernandes, Cecília M S Q Aranha, Flávia B Lopes

Publikováno v: Chemical Biology & Drug Design. 98:212-225

The role of histamine and acetylcholine in cognitive functions suggests that compounds able to increase both histaminergic and cholinergic neurotransmissions in the brain should be considered as promising therapeutic options. For this purpose, dual i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15cc949f72124019f957612243ae0f55
https://doi.org/10.1111/cbdd.13866

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Histamine H

Autor: Flávia B, Lopes, Cecília M S Q, Aranha, João Paulo S, Fernandes

Publikováno v: Chemical biologydrug designREFERENCES. 98(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::641c6b637c3a72be96eee4fce115ceb2
https://pubmed.ncbi.nlm.nih.gov/33991182

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Assessment of the physicochemical properties and stability for pharmaco-kinetic prediction of pyrazinoic acid derivatives

Autor: Cecília M S Q Aranha, João Paulo S. Fernandes, Michelle Fidelis Corrêa, Rone Aparecido DeGrandis, Rosângela Gonçalves Peccinini, Taísa Busaranho Franchin, Bruna Cristina Ulian Silva, Michel Leandro Campos

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2021-06-25T11:07:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: Tuberculosis (TB) is an infectious disease caused by Mycobacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8eea50cbf8152a08a27f755015da4c

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Profiling of LINS01 compounds at human dopamine D2 and D3 receptors

Autor: Gustavo A.B. Fernandes, Michelle Fidelis Corrêa, Cecília M S Q Aranha, Holger Stark, David Reiner, Marina T. Varela, João Paulo S. Fernandes

Publikováno v: Journal of Chemical Sciences. 132

Histamine and dopamine neuronal pathways display interesting overlapping in the CNS, especially in the limbic areas, making them very attractive to designing drugs with synergistic and/or additive effects. The roles of these systems to treat schizoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa6ed6f6d69956fd2a3567a6e4ab1696
https://doi.org/10.1007/s12039-019-1694-6

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