Mutations close to a hub residue affect the distant active site of a GH1 β-glucosidase.

Autor: Valquiria P Souza, Cecília M Ikegami, Guilherme M Arantes, Sandro R Marana

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198696 (2018)

The tertiary structure of proteins has been represented as a network, in which residues are nodes and their contacts are edges. Protein structure networks contain residues, called hubs or central, which are essential to form short connection pathways

Externí odkaz: https://doaj.org/article/e6f7979b5c3942bcbd53f509718c7fc5

Using the amino acid network to modulate the hydrolytic activity of beta-Glycosidases

Autor: Cecília M. Ikegami, Valquiria P. Souza, Diorge P. Souza, Sandro R. Marana, Chuck S. Farah, Fábio K. Tamaki

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 11, Iss 12, p e0167978 (2016)
PLoS ONE

The active site residues in GH1 β-glycosidases are compartmentalized into 3 functional regions, involved in catalysis or binding of glycone and aglycone motifs from substrate. However, it still remains unclear how residues outside the active site mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fe76017788752c1d565325902fa35d

Using the Amino Acid Network to Modulate the Hydrolytic Activity of β-Glycosidases.

Autor: Fábio K Tamaki, Diorge P Souza, Valquiria P Souza, Cecilia M Ikegami, Chuck S Farah, Sandro R Marana

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167978 (2016)

The active site residues in GH1 β-glycosidases are compartmentalized into 3 functional regions, involved in catalysis or binding of glycone and aglycone motifs from substrate. However, it still remains unclear how residues outside the active site mo

Externí odkaz: https://doaj.org/article/d650f3c1f1cd4f25addd69b7cf4d9133