Výsledky vyhledávání - "Cdk5 signaling"

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1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

Autor: Vittorio Canale, Wojciech Trybała, Séverine Chaumont-Dubel, Paulina Koczurkiewicz-Adamczyk, Grzegorz Satała, Ophélie Bento, Klaudia Blicharz-Futera, Xavier Bantreil, Elżbieta Pękala, Andrzej J. Bojarski, Frédéric Lamaty, Philippe Marin, Paweł Zajdel

Publikováno v: Biomolecules, Vol 13, Iss 1, p 12 (2022)

In addition to the canonical Gs adenylyl cyclase pathway, the serotonin type 6 receptor (5-HT6R) recruits additional signaling pathways that control cognitive function, brain development, and synaptic plasticity in an agonist-dependent and independen

Externí odkaz: https://doaj.org/article/359b495a9fb64b6395f525a0ff337ced

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Akademický článek

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2-Phenyl-1

Publikováno v: ACS Chemical Neuroscience

Serotonin type 6 receptor (5-HT6R) has gained particular interest as a promising target for treating cognitive deficits, given the positive effects of its antagonists in a wide range of memory impairment paradigms. Herein, we report on degradation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b39f9c6e7c183008eb0d775126f812f
https://pubmed.ncbi.nlm.nih.gov/33705101

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Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, 2021, 115, pp.105218. ⟨10.1016/j.bioorg.2021.105218⟩
Bioorganic Chemistry, Elsevier, 2021, 115, pp.105218. ⟨10.1016/j.bioorg.2021.105218⟩

International audience; The diverse signaling pathways engaged by serotonin type 6 receptor (5-HT6R) together with its high constitutive activity suggests different types of pharmacological interventions for the treatment of CNS disorders. Nonphysiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c9c2be6417dfafbec0f760844a061d
https://ruj.uj.edu.pl/xmlui/handle/item/277930

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2-Phenyl-1 H -pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT 6 Receptor Inverse Agonists with Cognition-Enhancing Activity

Publikováno v: ACS Chemical Neuroscience
ACS Chemical Neuroscience, 2021, 12 (7), pp.1228-1240. ⟨10.1021/acschemneuro.1c00061⟩
ACS Chemical Neuroscience, American Chemical Society (ACS), 2021, 12 (7), pp.1228-1240. ⟨10.1021/acschemneuro.1c00061⟩

International audience; Serotonin type 6 receptor (5-HT6R) has gained particular interest as a promising target for treating cognitive deficits, given the positive effects of its antagonists in a wide range of memory impairment paradigms. Herein, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc2cdb6c2920cc07bc3fc1b00b867ba
https://hal.science/hal-03192567

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Dual $5-HT_6$ and $D_3$ receptor antagonists in a group of 1H-pyrrolo[3,2-c]quinolines with neuroprotective and procognitive activity

Autor: Grychowska, Katarzyna, Chaumont-Dubel, Severine, Kurczab, Rafał, Koczurkiewicz, Paulina, Deville, Caroline, Krawczyk, Martyna, Pietruś, Wojciech, Satała, Grzegorz, Buda, Szymon, Piska, Kamil, Drop, Marcin, Bantreil, Xavier, Lamaty, Frederic, Pękala, Elżbieta, Bojarski, Andrzej, Popik, Piotr, Marin, Philippe, Zajdel, Paweł

Publikováno v: ACS Chemical Neuroscience
ACS Chemical Neuroscience, American Chemical Society (ACS), 2019, 10 (7), pp.3183-3196. ⟨10.1021/acschemneuro.8b00618⟩

International audience; In light of the multifactorial origin of neurodegenerative disorders and some body of evidence indicating that pharmacological blockade of serotonin 5-HT 6 and dopamine D 3 receptors might be beneficial for cognitive decline,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4b972b36f88e7bef29eb31db92459f
https://ruj.uj.edu.pl/xmlui/handle/item/84269

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Nestin as a regulator of Cdk5 in differentiating myoblasts

Autor: Tao He, Saima E. Ferraris, John E. Eriksson, Hanna-Mari Pallari, Cecilia Sahlgren, Elin Torvaldson, Julia Lindqvist

Publikováno v: Molecular Biology of the Cell
Pallari, H-M, Lindqvist, J, Torvaldson, E, Ferraris, S E, He, T, Sahlgren, C & Eriksson, J E 2011, ' Nestin as a regulator of Cdk5 in differentiating myoblasts ', Molecular Biology of the Cell, vol. 22, no. 9, pp. 1539-1549 . https://doi.org/10.1091/mbc.E10-07-0568
Molecular Biology of the Cell, 22(9), 1539-1549. American Society for Cell Biology

Our results show that the intermediate filament protein nestin regulates the early stages of myogenesis by a bidirectional interrelationship between nestin and Cdk5. Cdk5 regulates the organization and stability of its own scaffold nestin, which in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832c2730a077b46c3ce3b46d9ba958bd
https://doi.org/10.1091/mbc.e10-07-0568

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