Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Cdc42 GTP-Binding Protein/metabolism"'
1
On the influence of cell shape on dynamic reaction-diffusion polarization patterns
Autor: Steven Vermeulen, Aurélie Carlier, K. Eroume, Aliaksei S Vasilevich, J.G.G.M. de Boer
Publikováno v: PLoS ONE, 16(3):e0248293. Public Library of Science
PLoS ONE
PLOS ONE, 16(3):0248293. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0248293 (2021)
The distribution of signaling molecules following mechanical or chemical stimulation of a cell defines cell polarization, with regions of high active Cdc42 at the front and low active Cdc42 at the rear. As reaction-diffusion phenomena between signali
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a969f7b2c42e1e3a965f3916578244
https://doi.org/10.1371/journal.pone.0248293
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2
Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction
Autor: Sophie G. Martin, Daniela Gallo Castro
Publikováno v: The Journal of Cell Biology
The Journal of cell biology, vol. 217, no. 12, pp. 4215-4229
Local activity of the small GTPase Cdc42 is critical for cell polarization. Gallo Castro and Martin describe a new Cdc42 GTPase-activating protein (GAP) Rga3, which together with two other GAPs, constrains Cdc42-GTP zones during mitotic cycles but no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd9628567912afc1dcfa4b4b92a4ad1
http://europepmc.org/articles/PMC6279383
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3
Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase
Autor: Vincent Vincenzetti, Laura Merlini, Iker Lamas, Sophie G. Martin, Aleksandar Vjestica
Publikováno v: PLoS biology, vol. 18, no. 1, pp. e3000600
PLoS Biology, Vol 18, Iss 1, p e3000600 (2020)
PLoS Biology
Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas scaffold-mediated positive feedback was proposed to break symmetry of budding yeast cells and produce a single zone of Cdc42 activity, the existence of similar regula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545d82465c5c718399779415d9725133
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4
Exploration and stabilization of Ras1 mating zone: A mechanism with positive and negative feedbacks
Autor: Bita Khalili, Dimitrios Vavylonis, Sophie G. Martin, Vincent Vincenzetti, Laura Merlini
Publikováno v: PLoS Computational Biology, Vol 14, Iss 7, p e1006317 (2018)
PLoS computational biology, vol. 14, no. 7, pp. e1006317
PLOS Computational Biology
PLoS Computational Biology
In mating fission yeast cells, sensing and response to extracellular pheromone concentrations occurs through an exploratory Cdc42 patch that stochastically samples the cell cortex before stabilizing towards a mating partner. Active Ras1 (Ras1-GTP), a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cc0d77347d98fe64ed4d6cb4e4fd01
https://doaj.org/article/932ed06d1fa54e798cbe63011eb84d67
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5
The p21-activated Kinase 3 Implicated in Mental Retardation Regulates Spine Morphogenesis through a Cdc42-dependent Pathway
Autor: Dominique Muller, Emmanuel Thévenot, Véronique Rousseau, Bernadette Boda, Jean-Vianney Barnier, Patricia Kreis
Publikováno v: Journal of Biological Chemistry, Vol. 282, No 29 (2007) pp. 21497-21506
The p21-activated kinase 3 (PAK3) is one of the recently identified genes for which mutations lead to nonsyndromic mental retardation. PAK3 is implicated in dendritic spine morphogenesis and is a key regulator of synaptic functions. However, the unde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3661c681716036ec9b8a068da4795c40
https://doi.org/10.1074/jbc.m703298200
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6
Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking
Autor: Horst Vogel, Romain Wyss, Dimitrios Vavylonis, Vincent Vincenzetti, Sophie G. Martin, Felipe O. Bendezú
Publikováno v: PLoS Biology
PLoS Biology, vol. 13, no. 4, pp. e1002097
PLoS Biology, Vol 13, Iss 4, p e1002097 (2015)
The small Rho-family GTPase Cdc42 is critical for cell polarization and polarizes spontaneously in absence of upstream spatial cues. Spontaneous polarization is thought to require dynamic Cdc42 recycling through Guanine nucleotide Dissociation Inhibi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c34134b4e664df2cc67667dca3608ba
http://europepmc.org/articles/PMC4383620
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7
Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating
Autor: Sophie G. Martin, Felipe O. Bendezú, Laura Merlini, Bita Khalili, Daniel Hurwitz, Dimitrios Vavylonis, Vincent Vincenzetti
Publikováno v: Current biology, vol. 26, no. 8, pp. 1117-1125
Cell pairing is central for many processes, including immune defense, neuronal connection, hyphal fusion, and sexual reproduction. How does a cell orient toward a partner, especially when faced with multiple choices? Fission yeast Schizosaccharomyces
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e612914ab147af26847bc5865a99182
https://doi.org/10.1016/j.bpj.2015.11.817
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8
Fission yeast Sec3 and Exo70 are transported on actin cables and localize the exocyst complex to cell poles
Autor: Sophie G. Martin, Felipe O. Bendezú, Vincent Vincenzetti
Publikováno v: PLoS One, vol. 7, no. 6, pp. e40248
PLoS ONE, Vol 7, Iss 6, p e40248 (2012)
PLoS ONE
The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarized exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transpo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30fdf633479c30ccf1a7cf49731a931
https://serval.unil.ch/resource/serval:BIB_89C1BA2A0C75.P001/REF.pdf
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9
Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast
Autor: Felipe O. Bendezú, Sophie G. Martin
Publikováno v: Molecular Biology of the Cell, vol. 22, no. 1, pp. 44-53
Molecular biology of the cell
Molecular Biology of the Cell
In fission yeast, long-range transport and vesicle tethering by the exocyst are individually dispensable but together essential for cell morphogenesis. Both pathways function downstream of Cdc42. The exocyst localizes to growing cell tips independent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d447ef5e134fa756ef879db51ae91ca8
https://serval.unil.ch/resource/serval:BIB_DCBEA5F67977.P001/REF.pdf
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10
Regulation of the endothelial plasminogen activator system by fluvastatin. Role of Rho family proteins, actin polymerisation and p38 MAP kinase
Autor: Egbert K. O. Kruithof, Richard J. Fish, Sylvie Dunoyer-Geindre
Publikováno v: Thrombosis and Haemostasis, Vol. 105, No 3 (2011) pp. 461-72
Thrombosis and haemostasis
SummaryStatins are cholesterol-lowering drugs that exert pleiotropic effects which include changes in the plasminogen activation (PA) system of endothelial cells (EC). It was the objective of this study to investigate the signal transduction pathways
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c6b20a22859c0a01f8e803afb81bd1
https://pubmed.ncbi.nlm.nih.gov/21174002
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