Zobrazeno 1 - 10
of 23 605
pro vyhledávání: '"Cd8+ T Cells"'
Publikováno v:
BMC Biotechnology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Hepatitis B virus (HBV) clearance depends on an effective adaptive immune response, especially HBV-specific T cell-mediated cellular immunity; however, it is difficult to produce enough HBV-specific T cells effectively. Results In
Externí odkaz:
https://doaj.org/article/cb644856653b47de9cf946835ec7bbc9
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-20 (2024)
Abstract Background Gliomas are aggressive brain tumors with poor prognosis. Understanding the tumor immune microenvironment (TIME) in gliomas is essential for developing effective immunotherapies. This study aimed to identify TIME-related biomarkers
Externí odkaz:
https://doaj.org/article/3baa69fca70e49cd8c87a5212f3c671b
Autor:
Evgenii Skurikhin, Mariia Zhukova, Natalia Ermakova, Edgar Pan, Darius Widera, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Aslan Kubatiev, Sergey Morozov, Alexander Dygai
Publikováno v:
Thoracic Cancer, Vol 15, Iss 28, Pp 2000-2020 (2024)
Abstract Background Awareness of age‐related features of carcinogenesis and the importance of cellular immunity is crucial for developing effective antitumor therapies for specific patient groups. Methods In this study, we examined different popula
Externí odkaz:
https://doaj.org/article/14ea565086e046ae81cd8795708ec1a8
Autor:
Yikan Sun, Eloy Yinwang, Shengdong Wang, Zenan Wang, Fangqian Wang, Yucheng Xue, Wenkan Zhang, Shenzhi Zhao, Haochen Mou, Shixin Chen, Lingxiao Jin, Binghao Li, Zhaoming Ye
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract CD8+ T cells are the workhorses executing adaptive anti-tumour response, and targets of various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity of CD8+ tumour infiltrating lymphocytes, and made it increasingly
Externí odkaz:
https://doaj.org/article/fdda9f8f7434471a9afa3fccca6f7920
Autor:
Shouvik Chakravarty, Arnab Ghosh, Chitrarpita Das, Subrata Das, Subrata Patra, Arindam Maitra, Sandip Ghose, Nidhan K Biswas
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-7 (2024)
Abstract Background Precancerous and malignant tumours arise within the oral cavity from a predisposed “field” of epithelial cells upon exposure to carcinogenic stimulus. This phenomenon is known as “Field Cancerization”. The molecular genomi
Externí odkaz:
https://doaj.org/article/0f58565c800741e98eaf922e61245db5
Autor:
Yilin Ma, Kai Zheng, Chengcheng Zhao, Jieli Chen, Lin Chen, Yue Zhang, Tao Chen, Xiuhua Yao, Ying Cai, Jialing Wu
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Background Leukocyte immunoglobulin-like receptor B4 (LILRB4) plays a significant role in regulating immune responses. LILRB4 in microglia might influence the infiltration of peripheral T cells. However, whether and how LILRB4 expression agg
Externí odkaz:
https://doaj.org/article/eef18fd59ceb441897a1b3ca21529ce6
Autor:
Hao-Jia Sun, Zhui-Feng Zheng, Li-Jun Zhang, Le Fang, Hua Fu, Shao-Yang Chen, Rong-Xiu Feng, Xiao-Yang Liu, Qing-Nan Tang, Xue-Wen Liu
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Objective To assess the infiltration characteristics of tumour-associated macrophages (TAMs) in buccal mucosa carcinoma (BMC) and the correlation of these features with clinicopathological factors. Materials and methods Immunohistochemistry
Externí odkaz:
https://doaj.org/article/eadf546f0307429595a7607df0a5d2ce
Autor:
Cuixia Yang, Yuanchen Ma, Qiying Lu, Yuliang Qu, Yuantao Li, Shimei Cheng, Chongjun Xiao, Jinshuo Chen, Chuangjia Wang, Feng Wang, Andy Peng Xiang, Weijun Huang, Xiaorong Tang, Haiqing Zheng
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Treating Multiple sclerosis (MS), a well-known immune-mediated disease characterized by axonal demyelination, is challenging due to its complex causes. Naphthalenedione, present in numerous plants, is being explored as a potential medicine f
Externí odkaz:
https://doaj.org/article/99e7bcf9c25548299887b692c1b76af9
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Vitiligo and halo nevus are immune-mediated skin diseases that have a similar pathogenesis and involve cellular cytotoxicity mechanisms that are not yet fully understood. In this study, we investigated the expression patterns of the cytolyti
Externí odkaz:
https://doaj.org/article/22cfcec9488741458feea5c8bd9b5770
Autor:
Jiayi Yang, Xinyi Ding, Zhang Fang, Shaoxian Wu, Maoling Yuan, Rongzhang Chen, Qinlan Xu, Xinran Gao, Haoyu Wu, Lujun Chen, Xiao Zheng, Jingting Jiang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract CD8+T cells secreting granzyme A (GZMA) can induce pyroptosis in tumor cells by effectively cleaving gasdermin B (GSDMB), which is stimulated by interferon-γ (IFN-γ). However, the interaction between GZMA-expressing CD8+T cells and GSDMB-e
Externí odkaz:
https://doaj.org/article/2a6a89298a6f4656ac5255126ad989d9