Zobrazeno 1 - 10 of 818 pro vyhledávání: '"Cc, Harris"'
1
Synergism between the hbx gene and aflatoxin B-1 in the development of murine liver-cancer
Autor: H Ueda, G Jay, S Ohkoshi, Cc Harris
Publikováno v: International journal of oncology. 7(4)
Infection by hepatitis B virus (HBV) and exposure to dietary aflatoxin B-1 (AFB(1)) have both been implicated by epidemiological studies to be important risk factors in the development of hepatocellular carcinoma (HCC). Our ability to derive transgen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522e7f4cf4f671dc24de0731b88c5caf
https://pubmed.ncbi.nlm.nih.gov/21552896
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2
Functional studies of a germ-line polymorphism at codon 47 within the p53 gene
Autor: Emanuela Felley-Bosco, Weston A, Hm, Cawley, Wp, Bennett, Cc, Harris
Publikováno v: American Journal of Human Genetics, vol. 53, no. 3, pp. 752-759
Scopus-Elsevier
Europe PubMed Central
A rare germ-line polymorphism in codon 47 of the p53 gene replaces the wild-type proline (CCG) with a serine (TCG). Restriction analysis of 101 human samples revealed the frequency of the rare allele to be 0% (n = 69) in Caucasians and 4.7% (3/64, n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1ef0064344292f51329a9dc48e8fa2b7
https://pubmed.ncbi.nlm.nih.gov/8352280
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3
p53 mutations in lung cancers from non-smoking atomic-bomb survivors
Autor: Y Takeshima, WP Bennett, CE Land, CC Harris, K Inai, Y. Takeshima, T Seyama, M Akiyama, S Tokuoka, K Mabuchi
Publikováno v: The Lancet. 342:1520-1521
Tobacco smoke contains many carcinogens and has been linked with the development of lung cancer. We sequenced the conserved regions of the p53 tumour suppressor gene in lung cancers from 17 non-smokers from Hiroshima, Japan; 9 were atomic-bomb surviv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5001d97c65ced8a25d9649e2db42af29
https://doi.org/10.1016/s0140-6736(05)80087-x
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6
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression
Autor: Ambs S, Wg, Merriam, Wp, Bennett, Emanuela Felley-Bosco, Mo, Ogunfusika, Sm, Oser, Klein S, Pg, Shields, Tr, Billiar, Cc, Harris
Publikováno v: Europe PubMed Central
An increased expression of nitric oxide synthase (NOS) has been observed in human colon carcinoma cell lines as well as in human gynecological, breast, and central nervous system tumors. This observation suggests a pathobiological role of tumor-assoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a891d351652f87505e0fe5ae0475b6b5
http://europepmc.org/abstract/med/9443414
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7
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene
Autor: Xw, Wang, Mk, Gibson, Wim Vermeulen, Yeh H, Forrester K, Hw, Stürzbecher, Jh, Hoeijmakers, Cc, Harris
Publikováno v: Europe PubMed Central
The p53 tumor suppressor gene product is a transcriptional transactivator and a potent apoptotic inducer. The fact that many of the DNA tumor virus oncoproteins bind to p53 and affect these p53 functions indicates that this interaction is an importan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::34ee9414f45845cf7f2a849d5a08f41f
http://europepmc.org/abstract/med/8521383
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8
Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung
Autor: Sp, Hussain, Amstad P, Raja K, Sawyer M, Hofseth L, Pg, Shields, Hewer A, David Phillips, Ryberg D, Haugen A, Cc, Harris
Publikováno v: Europe PubMed Central
p53 mutations are common in lung cancer. In smoking-associated lung cancer,the occurrence of G:C to T:A transversions at hotspot codons, e.g., 157, 248, 249,and 273, has been linked to the presence of carcinogenic chemicalsin tobacco smoke including
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::358866bf549a2b198f7c30c685e9e913
http://europepmc.org/abstract/med/11522624
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9
Repair of DNA damage caused by formaldehyde in human cells
Autor: Rc, Grafstrom, Albert Fornace, Cc, Harris
Publikováno v: Europe PubMed Central
The alkaline elution technique was used to study repair of DNA damage caused by formaldehyde (HCHO) in human bronchial epithelial cells and fibroblasts, skin fibroblasts, and DNA excision repair-deficient skin fibroblasts from donors with xeroderma p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ba995a3eed815ca81239ad7aba2b981f
http://europepmc.org/abstract/med/6467194
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