Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Cbp p300"'
Autor:
Isaac W Vock, Allison J L Huldin, Matthew S. Beyersdorf, Anna K. Mapp, Stephen T. Joy, Matthew J. Henley, Samantha N. De Salle
Publikováno v:
Journal of the American Chemical Society. 143:15056-15062
The protein-protein interaction between the KIX motif of the transcriptional coactivator CBP/p300 and the transcriptional activator Myb is a high-value target due to its established role in certain acute myeloid leukemias (AML) and potential contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ebbb0da5e342fc7dc19fb4928ab873
https://doi.org/10.1021/jacs.1c04432
https://doi.org/10.1021/jacs.1c04432
Autor:
Gagan Dhawan, Jon Erickson, Wei Zhang, Tingjian Wang, Zied Gaieb, Deyao Li, Jun Qi, Shuai Liu, Logan H. Sigua, Hailemichael O. Yosief, Ernst Schönbrunn, Virangika K. Wimalasena, Alex Muthengi, M.J. Bikowitz, Rommie E. Amaro
Publikováno v:
Journal of Medicinal Chemistry. 64:5787-5801
The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodomain extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET bromodomain oncology targets ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7259551e2d56da80bb9e97f159ccab6
https://doi.org/10.1021/acs.jmedchem.0c02232
https://doi.org/10.1021/acs.jmedchem.0c02232
Publikováno v:
Klinische Pädiatrie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a35ceaa8403d9527f127b7da4d72b8c4
https://doi.org/10.1055/s-0040-1709778
https://doi.org/10.1055/s-0040-1709778
Publikováno v:
Frontiers in Biology. 13:168-179
CREB binding protein (CBP) and its close paralogue p300 are transcriptional coactivators with intrinsic acetyltransferase activity. Both CBP/p300 play critical roles in development and diseases. The enzymatic and biological functions of CBP/p300 are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f6b7837e2b1c1afabf4230a89ca152d
https://doi.org/10.1007/s11515-018-1502-6
https://doi.org/10.1007/s11515-018-1502-6
Autor:
Yuwei Wang, Xiaojun Yao, Elaine Lai-Han Leung, Qianqian Wang, Liang Liu, Jiahui Xu, Xiaoli An
Publikováno v:
Organic & Biomolecular Chemistry. 16:6521-6530
The selective modulation of individual bromodomains (BDs) by small molecules represents an important strategy for the treatment of various cancers, considering that the BD-containing proteins share common BD structures and distinct pharmacological fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d34ce75091d318f1d5303c2e02e2a1f
https://doi.org/10.1039/c8ob01526k
https://doi.org/10.1039/c8ob01526k
Autor:
Maureen Beresini, Vickie Tsui, John S. Wai, F. Anthony Romero, Gladys de Leon Boenig, Patrick Cyr, Xiaoyu Zhu, Kevin X. Chen, Jiangpeng Liao, Edna F. Choo, Susan Kaufman, Fei Wang, Kwong Wah Lai, Caicai Zhu, Zhongguo Chen, Terry Crawford, Weichao Shen, Wenfeng Liu, Jeremy Murray, Yingjie Li, Sarah M. Bronner, Steven Magnuson, Justin Ly
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:15-23
A novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP, compound 35 (GNE-207), has been identified through SAR investigations focused on optimizing al bicyclic heteroarene to replace the aniline present in the published GNE-272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a093625fe16457098a0a0b8d624a6c4e
https://doi.org/10.1016/j.bmcl.2017.11.025
https://doi.org/10.1016/j.bmcl.2017.11.025
Autor:
Alex Sedkov, Michael S. Gordon, Sylvie Guichard, Sonia Kumar, Melissa A. Reimers, Juliana Snavely-Merhaut, Kate Lipford, Neal D. Shore, Andrew J. Armstrong
Publikováno v:
Journal of Clinical Oncology. 39:TPS5085-TPS5085
TPS5085 Background: Prostate cancer is the second leading cause of cancer-related death among men in the U.S., largely due to metastatic disease that progresses despite hormonal therapy (tx). The role for androgen receptor (AR) signaling in prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f2b90e43289b9adb5bfb4e459c5a4fc
https://doi.org/10.1200/jco.2021.39.15_suppl.tps5085
https://doi.org/10.1200/jco.2021.39.15_suppl.tps5085
Autor:
Andy Conery, Jann N. Sarkaria, Danielle M. Burgenske, Archana Bommi-Reddy, Jonathan E. Wilson, Katrina K. Bakken, Lihong He, Zeng Hu, Gaspar J. Kitange, Brett L. Carlson
Publikováno v:
Neuro Oncol
There is an unmet need to identify novel targets that can sensitize temozolomide (TMZ) or prevent resistance in GBM. We have demonstrated that retinoblastoma binding protein 4 (RBBP4) interacts with p300 to modulate expression of genes involved in ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9727cae8fad2c540780055762f8198a2
https://doi.org/10.1093/neuonc/noaa215.366
https://doi.org/10.1093/neuonc/noaa215.366