Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Caylin G. Winchell"'
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques
Autor:
Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Mohd Saqib, Samantha J. Nelson, Pauline Maiello, Chelsea M. Causgrove, Cassaundra L. Ameel, Brianne Stein, H. Jacob Borish, Alexander G. White, Edwin C. Klein, Matthew D. Zimmerman, Véronique Dartois, Philana Ling Lin, Christopher M. Sassetti, JoAnne L. Flynn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is
Externí odkaz:
https://doaj.org/article/cb9c7db12abd401b9c0a88eb06a4e51b
The role of lymphocyte subsets in preventing tuberculosis following intravenous vaccination with BCG
Autor:
Andrew W Simonson, Allison N Bucsan, Joseph J Zeppa, Caylin G Winchell, Amy J Myers, Matthew Sutton, Cassaundra L Ameel, Patricia A Darrah, Mario Roederer, Robert A Seder, JoAnne L Flynn
Publikováno v:
The Journal of Immunology. 208:181.11-181.11
Background We previously demonstrated in non-human primates (NHP) that intravenous (IV) administration of BCG induces substantial T cell responses and often sterilizing immunity against Mycobacterium tuberculosis (Mtb) infection. Here, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fe046269709b0eb13d648706123b50f
https://doi.org/10.4049/jimmunol.208.supp.181.11
https://doi.org/10.4049/jimmunol.208.supp.181.11
Autor:
Hannah P. Gideon, Travis K. Hughes, Constantine N. Tzouanas, Marc H. Wadsworth, Ang Andy Tu, Todd M. Gierahn, Joshua M. Peters, Forrest F. Hopkins, Jun-Rong Wei, Conner Kummerlowe, Nicole L. Grant, Kievershen Nargan, Jia Yao Phuah, H. Jacob Borish, Pauline Maiello, Alexander G. White, Caylin G. Winchell, Sarah K. Nyquist, Sharie Keanne C. Ganchua, Amy Myers, Kush V. Patel, Cassaundra L. Ameel, Catherine T. Cochran, Samira Ibrahim, Jaime A. Tomko, Lonnie James Frye, Jacob M. Rosenberg, Angela Shih, Michael Chao, Edwin Klein, Charles A. Scanga, Jose Ordovas-Montanes, Bonnie Berger, Joshua T. Mattila, Rajhmun Madansein, J. Christopher Love, Philana Ling Lin, Alasdair Leslie, Samuel M. Behar, Bryan Bryson, JoAnne L. Flynn, Sarah M. Fortune, Alex K. Shalek
Publikováno v:
Immunity. 55:827-846.e10
Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4751cc76c4a7d51734d0705b3934fa
https://doi.org/10.1016/j.immuni.2022.04.004
https://doi.org/10.1016/j.immuni.2022.04.004
Autor:
Hannah P. Gideon, Travis K. Hughes, Constantine N. Tzouanas, Marc H. Wadsworth, Ang Andy Tu, Todd M. Gierahn, Joshua M. Peters, Forrest F. Hopkins, Jun-Rong Wei, Conner Kummerlowe, Nicole L. Grant, Kievershen Nargan, Jia Yao Phuah, H. Jacob Borish, Pauline Maiello, Alexander G. White, Caylin G. Winchell, Sarah K. Nyquist, Sharie Keanne C. Ganchua, Amy Myers, Kush V Patel, Cassaundra L. Ameel, Catherine T. Cochran, Samira Ibrahim, Jaime A Tomko, Lonnie James Frye, Jacob M. Rosenberg, Angela Shih, Michael Chao, Charles A. Scanga, Jose Ordovas-Montanes, Bonnie Berger, Joshua T. Mattila, Rajhmun Madansein, J. Christopher Love, Philana Ling Lin, Alasdair Leslie, Samuel M. Behar, Bryan Bryson, JoAnne L Flynn, Sarah M. Fortune, Alex K. Shalek
Mycobacterium tuberculosis lung infection results in a complex multicellular structure, the granuloma. In some granulomas, immune activity promotes bacterial clearance; in others, bacteria persist and grow. We identified correlates of bacterial contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7560139895ed4573b1d19bd67d012bd6
https://doi.org/10.1101/2020.10.24.352492
https://doi.org/10.1101/2020.10.24.352492
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques
Autor:
Cassaundra Ameel, Alexander G. White, Matthew D. Zimmerman, Jia Yao Phuah, Edwin Klein, Caylin G. Winchell, Mohd Saqib, Brianne Stein, Véronique Dartois, Christopher M. Sassetti, Pauline Maiello, Chelsea M Causgrove, Bibhuti B. Mishra, JoAnne L. Flynn, H. Jacob Borish, Samantha J. Nelson, Philana Ling Lin
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23e2259e484ed0833511f0d768e0a30
http://europepmc.org/articles/PMC7235418
http://europepmc.org/articles/PMC7235418
Autor:
Carly Ziegler, Samuel J. Allon, Sarah K. Nyquist, Ian Mbano, Vincent N. Miao, Yuming Cao, Ashraf S. Yousif, Julia Bals, Blake M. Hauser, Jared Feldman, Christoph Muus, Marc H. Wadsworth II, Samuel Kazer, Travis K. Hughes, Benjamin Doran, G. James Gatter, Marko Vukovic, Constantine N. Tzouanas, Faith Taliaferro, Zhiru Guo, Jennifer P. Wang, Daniel F. Dwyer, Kathleen M. Buchheit, Joshua Boyce, Nora A. Barrett, Tanya M. Laidlaw, Shaina L. Carroll, Lucrezia Colonna, Victor Tkachev, Alison Yu, Henqi Betty Zheng, Hannah P. Gideon, Caylin G. Winchell, Philana L. Lin, Bonnie Berger, Alasdair Leslie, JoAnne L. Flynn, Sarah M. Fortune, Robert W. Finberg, Leslie Kean, Manuel Garber, Aaron Schmidt, Daniel Lingwood, Alex K. Shalek, Jose Ordovas-Montanes, HCA Lung Biological Network
Publikováno v:
SSRN Electronic Journal.
There is pressing urgency to better understand the pathogenesis of the severe acute respiratory syndrome (SARS) coronavirus (CoV) clade SARS-CoV-2. SARS-CoV-2, like SARS-CoV, utilizes ACE2 to bind host cells. While initial SARS-CoV-2 cell entry and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81272cd8e0ea6056453adc612559367
https://doi.org/10.2139/ssrn.3555145
https://doi.org/10.2139/ssrn.3555145
Publikováno v:
Current Opinion in Microbiology. 29:9-14
Intracellular bacterial pathogens have evolved many ways to manipulate host cells for successful infection. Many of these pathogens use specialized secretion systems to inject bacterial proteins into the host cytosol that manipulate cellular processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c5f18c3e6e8034d87d63ab19d4be5c
https://doi.org/10.1016/j.mib.2015.09.004
https://doi.org/10.1016/j.mib.2015.09.004
Autor:
Alex K. Shalek, Kun Zhang, Christopher W. Peterson, Orit Rosen, Alison Yu, Robert Lafyatis, Samuel W. Kazer, Oliver Eickelberg, Sarah A. Teichmann, Mauricio Rojas, Martijn C. Nawijn, Colin D. Bingle, Thu Elizabeth Duong, Manuel Garber, Magali Plaisant, Philana Ling Lin, Christine S. Falk, Jennifer P. Wang, Xin Sun, Hengqi Betty Zheng, G. James Gatter, Sarah K. Nyquist, Malte Kühnemund, Joachim L. Schultze, Mark A. Krasnow, Maarten van den Berge, Yan Xu, Samuel J. Allon, Daniel F. Dwyer, Peter Horvath, Benjamin Doran, Brian M. Lin, Herbert B. Schiller, Blake M. Hauser, Fabian J. Theis, Avrum Spira, Paul A. Reyfman, Hans-Peter Kiem, Shaina L. Carroll, Zhiru Guo, Douglas P. Shepherd, Michael von Papen, Ian M. Mbano, Michael Farzan, Daniel Lingwood, JoAnne L. Flynn, Christoph Muus, Dana Pe'er, Stephen R. Quake, Travis K. Hughes, Sarah M. Fortune, Sten Linnarson, Chase J. Taylor, Tanya M. Laidlaw, Emma L. Rawlins, Bonnie Berger, Ashraf S. Yousif, Joakim Lundeberg, Jeffrey A. Whitsett, Ian A. Glass, Delphine Gras, Max A. Seibold, Jay Rajagopal, Jared Feldman, Victor Tkachev, Benjamin E. Mead, Joseph E. Powell, Aviv Regev, Alasdair Leslie, Robert W. Finberg, Yuming Cao, Jennifer M.S. Sucre, Marko Vukovic, Scott B. Snapper, Vincent N. Miao, Naftali Kaminski, Laure-Emmanuelle Zaragosi, Caylin G. Winchell, Faith Taliaferro, Marko Nikolic, Ilias Angelidis, Leslie S. Kean, Lucrezia Colonna, Kathleen M. Buchheit, Aaron G. Schmidt, Ramnik J. Xavier, Tushar J. Desai, Marc H. Wadsworth, Joshua A. Boyce, Alexander M. Tsankov, Nora A. Barrett, Pascal Barbry, Muzlifah Haniffa, Heiko Adler, Alvis Brazma, Hannah P. Gideon, Meshal Ansari, Jason R. Spence, Avinash Waghray, Constantine N. Tzouanas, Jose Ordovas-Montanes, Jonathan A. Kropski, Nicholas E. Banovich, Purushothama Rao Tata, Kerstin B. Meyer, Christos Samakovlis, Haeock Lee, Carly G. K. Ziegler, Alexander V. Misharin, Deborah T. Hung, Sylvie Leroy, Julia Bals, Vanessa Mitsialis, Kourosh Saeb-Parsy
Publikováno v:
Cell
Cell, 2020, 181 (5), pp.1016-1035.e19. ⟨10.1016/j.cell.2020.04.035⟩
Cell, Elsevier, 2020, 181 (5), pp.1016-1035.e19. ⟨10.1016/j.cell.2020.04.035⟩
Cell 181, 1016-1035 (2020)
Elsevier
Cell, 181(5), 1016-1035.e19. CELL PRESS
Cell, 2020, 181 (5), pp.1016-1035.e19. ⟨10.1016/j.cell.2020.04.035⟩
Cell, Elsevier, 2020, 181 (5), pp.1016-1035.e19. ⟨10.1016/j.cell.2020.04.035⟩
Cell 181, 1016-1035 (2020)
Elsevier
Cell, 181(5), 1016-1035.e19. CELL PRESS
Summary There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727543612f7db162539d6c42ca832836
https://doi.org/10.1016/j.cell.2020.04.035
https://doi.org/10.1016/j.cell.2020.04.035
Autor:
Katelynn R. Brann, Caylin G. Winchell, Amanda L. Dragan, Daniel E. Voth, Frances I. Onyilagha, Richard C. Kurten
Publikováno v:
Infection and Immunity. 86
Coxiella burnetii is the causative agent of human Q fever, a debilitating flu-like illness that can progress to chronic disease presenting as endocarditis. Following inhalation, C. burnetii is phagocytosed by alveolar macrophages and generates a lyso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b861356c19d30c7a9cc554455c0e00d
https://doi.org/10.1128/iai.00608-17
https://doi.org/10.1128/iai.00608-17
Publikováno v:
The Journal of Immunology. 202:190.3-190.3
An estimated 558,000 cases of drug-resistant tuberculosis (TB) occurred in 2017, emphasizing a need for new treatment strategies. We assessed a host-directed therapy (HDT) for TB using two FDA-approved drugs. Linezolid (LZD) is a potent antibiotic fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0674cb6e012d816165d84b5a717cdc92
https://doi.org/10.4049/jimmunol.202.supp.190.3
https://doi.org/10.4049/jimmunol.202.supp.190.3