Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Cayla M. McEwen"'
Autor:
Spiros Liras, Cayla M. McEwen, Rushia A. Turner, David Price, Taha Rezai, Amit S. Kalgutkar, Roger G. Linington, Alan M. Mathiowetz, R. Scott Lokey, Matthew P. Jacobson, Arthur C Rand, Yizhong Zhang, Vladimir Gelev, Chad M. Renzelman, Siegfried S. F. Leung, Tina R White, Jonathan N. Bauman
Publikováno v:
Nature chemical biology
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides. However, the specific impact of N-methylation on passive membrane diffusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f47aa6fd7e54ac01592ee97bdf664d5
https://doi.org/10.1038/nchembio.664
https://doi.org/10.1038/nchembio.664
Publikováno v:
Current topics in medicinal chemistry. 13(7)
The structural complexity of many natural products sets them apart from common synthetic drugs, allowing them to access a biological target space that lies beyond the enzyme active sites and receptors targeted by conventional small molecule drugs. Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4179ab316440af3d8901099f4ba09ddb
https://pubmed.ncbi.nlm.nih.gov/23578026
https://pubmed.ncbi.nlm.nih.gov/23578026