Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Cayla E. Jewett"'
Publikováno v:
Biology Open, Vol 9, Iss 10 (2020)
The Rab11 apical recycling endosome pathway is a well-established regulator of polarity and lumen formation; however, Rab11-vesicular trafficking also directs a diverse array of other cellular processes, raising the question of how Rab11 vesicles ach
Externí odkaz:
https://doaj.org/article/cfd20f31f65d4b8a8cb6bff97118cd53
Autor:
Cayla E. Jewett, Timothy E. Vanderleest, Hui Miao, Yi Xie, Roopa Madhu, Dinah Loerke, J. Todd Blankenship
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Various stages of tissue morphogenesis involve the contraction of epithelial surfaces. Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure unidirection
Externí odkaz:
https://doaj.org/article/ffd112e8fb114efa851ecacc98fe3c75
Autor:
Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson
Publikováno v:
eLife, Vol 12 (2023)
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related mole
Externí odkaz:
https://doaj.org/article/603a4f2550174b548dd163691ee11a05
Autor:
Timothy E Vanderleest, Celia M Smits, Yi Xie, Cayla E Jewett, J Todd Blankenship, Dinah Loerke
Publikováno v:
eLife, Vol 7 (2018)
Oriented cell intercalation is an essential developmental process that shapes tissue morphologies through the directional insertion of cells between their neighbors. Previous research has focused on properties of cell–cell interfaces, while the fun
Externí odkaz:
https://doaj.org/article/546b9665542c43d2a378a701d57820f8
Autor:
Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff97882767f035a39da8c4fcb1c6f24
https://doi.org/10.7554/elife.78202.sa2
https://doi.org/10.7554/elife.78202.sa2
Autor:
Alexander J. Stemm-Wolf, Joaquín M. Espinosa, Chad G. Pearson, Cayla E. Jewett, Molishree Joshi, Rytis Prekeris, Huy Nguyen Duc, Bailey L. McCurdy
Publikováno v:
Molecular Biology of the Cell. 33
Trisomy 21, the cause of Down syndrome, causes a 0.5-fold protein increase of the chromosome 21-resident gene Pericentrin (PCNT) and reduces primary cilia formation and signaling. Here we investigate the mechanisms by which PCNT imbalances disrupt ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f94c2b5a2eda08559836083ef1f127
https://doi.org/10.1091/mbc.e21-10-0517-t
https://doi.org/10.1091/mbc.e21-10-0517-t
Autor:
Chad G. Pearson, Cayla E. Jewett
Publikováno v:
Current Biology. 31:R337-R340
Extra centrosomes are linked to cancer-associated errors in cell division, metastasis and signaling. A new study reveals that centrosome amplification disrupts lysosome function, leading to the release of small extracellular vesicles and to invasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b654b772b58ae24e1663047ab7cde76
https://doi.org/10.1016/j.cub.2021.01.057
https://doi.org/10.1016/j.cub.2021.01.057
Autor:
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland
Publikováno v:
eLife. 11
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bfd730a9fbef917906d2464a1574cc
https://pubmed.ncbi.nlm.nih.gov/36149392
https://pubmed.ncbi.nlm.nih.gov/36149392
Autor:
Eileen T. O'Toole, Laura G. Reinholdt, Wendy B. Macklin, Katherine S Given, Carrie H. Lin, Valerie Olsen, Joaquín M. Espinosa, Whitney Martin, Bailey L McCurdy, Cayla E. Jewett, Chad G. Pearson, Kelly D. Sullivan, Rytis Prekeris
SummaryPrimary cilia are signaling organelles essential for development and homeostasis. Loss of primary cilia is lethal, and decreased or defective cilia cause multisystemic conditions called ciliopathies. Down syndrome shares clinical overlap with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a978c6f17ccae2c6ec28df3dcacff233
https://doi.org/10.1101/2021.11.10.468107
https://doi.org/10.1101/2021.11.10.468107