Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cayla Broton"'
Autor:
Brooke A. Conti, Penelope D. Ruiz, Cayla Broton, Nicolas J. Blobel, Molly C. Kottemann, Sunandini Sridhar, Francis P. Lach, Tom F. Wiley, Nanda K. Sasi, Thomas Carroll, Agata Smogorzewska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA replication through a challenging genomic landscape is coordinated by the replisome, which must adjust to local conditions to provide appropriate replication speed and respond to lesions that hinder its progression. We have previously sh
Externí odkaz:
https://doaj.org/article/bb0f43ef23d34a678edc5ee4e00c721c
Autor:
Alessandro Cicconi, Rekha Rai, Xuexue Xiong, Cayla Broton, Amer Al-Hiyasat, Chunyi Hu, Siying Dong, Wenqi Sun, Jennifer Garbarino, Ranjit S. Bindra, Carl Schildkraut, Yong Chen, Sandy Chang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Primary microcephaly is a clinical feature of several human telomere disorder syndromes. Here the authors reveal a role of Microcephalin 1 in promoting telomere replication and repair.
Externí odkaz:
https://doaj.org/article/1ffe736cceae4b6a9ede6a1d1309b5e3
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3708-3725.e5 (2019)
Summary: Telomeres use shelterin to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), repressing ataxia-telangiectasia, mutated (ATM) and ATM and Rad3-related (ATR) dependent DNA damage checkpoint responses. The MR
Externí odkaz:
https://doaj.org/article/0f21ce0df63548b298e21688e96c06dc
Autor:
Brooke A. Conti, Penelope D. Ruiz, Cayla Broton, Nicolas J. Blobel, Molly C. Kottemann, Sunandini Sridhar, Francis P. Lach, Tom Wiley, Nanda K. Sasi, Thomas Carroll, Agata Smogorzewska
Publikováno v:
bioRxiv
Genetic information is duplicated via the highly regulated process of DNA replication. The machinery coordinating this process, the replisome, encounters many challenges, including replication fork-stalling lesions that threaten the accurate and time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da392f37a28108837fa33207a1cb1cd
https://europepmc.org/articles/PMC10054921/
https://europepmc.org/articles/PMC10054921/
Autor:
Alan W. Leung, Cayla Broton, Yan-Ru Lou, Mariia S. Bogacheva, Martín I. García-Castro, Andrew Xiao
Publikováno v:
Journal of molecular biology. 432(13)
Current approaches for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-Associated-9 (Cas9)-mediated genome editing in human pluripotent stem (PS) cells mainly employ plasmids or ribonucleoprotein complexes. Here, we devise a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa668ad82ab8b69170a0f3f9967453f
https://pubmed.ncbi.nlm.nih.gov/32339532
https://pubmed.ncbi.nlm.nih.gov/32339532
Autor:
Ranjit S. Bindra, Cayla Broton, Chunyi Hu, Carl L. Schildkraut, Yong Chen, Alessandro Cicconi, Xuexue Xiong, Sandy Chang, Rekha Rai, Jennifer Garbarino, Amer Al-Hiyasat, Siying Dong, Wenqi Sun
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccf2abf2a262fdf994ec7f3ad13f324
https://pubmed.ncbi.nlm.nih.gov/33203878
https://pubmed.ncbi.nlm.nih.gov/33203878
Autor:
Yong Chen, Sandy Chang, Chenhui Huang, Chunyi Hu, Juanjuan Long, Jing Xue, Rekha Rai, Ying Xu, Ming Lei, Cayla Broton
Publikováno v:
Cell Research. 27:1485-1502
Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 heterodimer binds to single-stranded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44310f61b3e2571acb32ef941cb18325
https://doi.org/10.1038/cr.2017.144
https://doi.org/10.1038/cr.2017.144
Autor:
Cayla Broton, Jacqueline C. Hernandez, Kaixuan Lin, Martín I. García-Castro, Alan W. Leung, Andrew Xiao, Maneeshi S. Prasad, Francesc López-Giráldez
SUMMARYWhat are the factors that are induced during the transitory phases from pluripotent stem cells to lineage specified cells, how are they regulated, and what are their functional contributions are fundamental questions for basic developmental bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f3dae4ef10066b77005c5c758500af
Publikováno v:
Cell reports
Cell Reports, Vol 29, Iss 11, Pp 3708-3725.e5 (2019)
Cell Reports, Vol 29, Iss 11, Pp 3708-3725.e5 (2019)
SUMMARY Telomeres use shelterin to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), repressing ataxia-telangiectasia, mutated (ATM) and ATM and Rad3-related (ATR) dependent DNA damage checkpoint responses. The MRE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b145bfdb01e375a74fce00c5d4ad6de5
https://pubmed.ncbi.nlm.nih.gov/31825846
https://pubmed.ncbi.nlm.nih.gov/31825846