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Akademický článek

Effect of cytokine-induced alterations in extracellular matrix composition on diabetic retinopathy-relevant endothelial cell behaviors

Autor: Meredith J. Giblin, Cayla D. Ontko, John S. Penn

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Retinal vascular basement membrane (BM) thickening is an early structural abnormality of diabetic retinopathy (DR). Recent studies suggest that BM thickening contributes to the DR pathological cascade; however, much remains to be elucidated

Externí odkaz: https://doaj.org/article/d162bd408f024d5291eb0ac80c247ffa

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Coprime and prime labelings of graphs

Autor: Berliner, Adam H., Dean, Nathaniel, Hook, Jonelle, Marr, Alison, Mbirika, Aba, McBee, Cayla D.

Publikováno v: Journal of Integer Sequences, Vol. 19 (2016), Article 16.5.8

A coprime labeling of a simple graph of order $n$ is a labeling in which adjacent vertices are given relatively prime labels, and a graph is prime if the labels used can be taken to be the first $n$ positive integers. In this paper, we consider when

Externí odkaz: http://arxiv.org/abs/1604.07698

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Akademický článek

Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

Autor: Vera M. Todd, Lawrence A. Vecchi, Miranda E. Clements, Katherine P. Snow, Cayla D. Ontko, Lauren Himmel, Christopher Pinelli, Marjan Rafat, Rachelle W. Johnson

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)

Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They fin

Externí odkaz: https://doaj.org/article/975f1c09009840709de77452a7dc73cb

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Akademický článek

Cytochrome P450-epoxygenated fatty acids inhibit Müller glial inflammation

Autor: Cayla D. Ontko, Megan E. Capozzi, Minjae J. Kim, Gary W. McCollum, John S. Penn

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Free fatty acid dysregulation in diabetics may elicit the release of inflammatory cytokines from Müller cells (MC), promoting the onset and progression of diabetic retinopathy (DR). Palmitic acid (PA) is elevated in the sera of diabetics an

Externí odkaz: https://doaj.org/article/47a5c08f9bd747bdbb9357e26fe836ae

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