Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Cayetano von Kobbe"'
Autor:
María Ángeles Rodríguez-Hernández, Mercedes Baena-Bustos, David Carneros, Carola Zurita-Palomo, Pablo Muñoz-Pinillos, Jaime Millán, Francisco Javier Padillo, Cristian Smerdou, Cayetano von Kobbe, Stefan Rose-John, Matilde Bustos
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105132- (2024)
Summary: Background: SARS-CoV-2 infection is considered as a relapsing inflammatory process with a dysregulation of IL-6 signalling. Classic IL-6 signalling is thought to represent a defence mechanism against pathogens. In contrast, IL-6 trans-signal
Externí odkaz:
https://doaj.org/article/cb1a454d27374e47aa940a4799b66b43
Autor:
Sabina Andreu, Cayetano von Kobbe, Pilar Delgado, Inés Ripa, María José Buzón, Meritxell Genescà, Núria Gironès, Javier del Moral-Salmoral, Gustavo A. Ramírez, Sonia Zúñiga, Luis Enjuanes, José Antonio López-Guerrero, Raquel Bello-Morales
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The emergent human coronavirus SARS-CoV-2 and its resistance to current drugs makes the need for new potent treatments for COVID-19 patients strongly necessary. Dextran sulfate (DS) polysaccharides have long demonstrated antiviral activity against di
Externí odkaz:
https://doaj.org/article/6c50246dc6634b60b6f02faec3a06d48
Autor:
Juan Martin Caballero, Ana Garzón, Leticia González-Cintado, Wioleta Kowalczyk, Ignacio Jimenez Torres, Gloria Calderita, Margarita Rodriguez, Virgínia Gondar, Juan Jose Bernal, Carlos Ardavín, David Andreu, Thomas Zürcher, Cayetano von Kobbe
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52976 (2012)
Cervical cancer is caused by persistent high-risk human papillomavirus (HR-HPV) infection and represents the second most frequent gynecological malignancy in the world. The HPV-16 type accounts for up to 55% of all cervical cancers. The HPV-16 oncopr
Externí odkaz:
https://doaj.org/article/8a5d7a250c8a4e8286cf220723d7dc30
Autor:
Andrés Pastor‐Fernández, Antonio R. Bertos, Arantzazu Sierra‐Ramírez, Javier del Moral‐Salmoral, Javier Merino, Ana I. de Ávila, Cristina Olagüe, Ricardo Villares, Gloria González‐Aseguinolaza, María Ángeles Rodríguez, Manuel Fresno, Nuria Gironés, Matilde Bustos, Cristian Smerdou, Pablo Jose Fernandez‐Marcos, Cayetano von Kobbe
The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de2271032cae449504e371bc6b7e402
http://hdl.handle.net/10261/308426
http://hdl.handle.net/10261/308426
Autor:
Cayetano von Kobbe
Publikováno v:
Cellular and Molecular Life Sciences. 75:3553-3567
Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse effects on the organism. Many studies have been done
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09ac785de52f13c9018b7766c718d46
https://doi.org/10.1007/s00018-018-2879-8
https://doi.org/10.1007/s00018-018-2879-8
Autor:
Cayetano von Kobbe
Publikováno v:
Aging (Albany NY)
Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and non-cell autonomous processes, leading to several consequences for the organism. To date, several senescence routes have been identified, which play a fund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a620d617d88972442faa7511a2184356
http://hdl.handle.net/10261/216200
http://hdl.handle.net/10261/216200
Autor:
Meltem Muftuoglu, Wen-Hsing Cheng, Cayetano von Kobbe, Dru F. Leistritz, Vilhelm A. Bohr, Junko Oshima
Publikováno v:
Human Genetics. 124:369-377
Werner syndrome (WS) is an adult onset segmental progeroid syndrome caused by mutations in the WRN gene. The WRN gene encodes a 180 kDa nuclear protein that possesses helicase and exonuclease activities. The absence of WRN protein leads to abnormalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ebd50556b7b72a2f56dacf4a8d3dc5
https://doi.org/10.1007/s00439-008-0562-0
https://doi.org/10.1007/s00439-008-0562-0
Autor:
Jin-Shan Hu, Guang-Xin Lin, Robert M. Brosh, Jae Wan Lee, Kevin M. Doherty, Wen-Hsing Cheng, Cayetano von Kobbe, Wangyong Zeng, Rika Kusumoto, Vilhelm A. Bohr
Publikováno v:
Journal of Biological Chemistry. 280:39627-39636
Naturally occurring mutations in the human RECQ3 gene result in truncated Werner protein (WRN) and manifest as a rare premature aging disorder, Werner syndrome. Cellular and biochemical studies suggest a multifaceted role of WRN in DNA replication, D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14a20fd8c0bb259bd7f874439df2d10
https://doi.org/10.1074/jbc.m506112200
https://doi.org/10.1074/jbc.m506112200
Autor:
Ji Lan Liu, Matthew D. Gray, Vilhelm A. Bohr, Michael M. Seidman, Alokes Majumdar, Jeanine A. Harrigan, Cayetano von Kobbe, E. Jeffery Metter, David M. Wilson
Publikováno v:
Mechanisms of Ageing and Development. 125:491-496
The leading causes of death for individuals with Werner syndrome (WS) are myocardial infarction (MI) and stroke. The WS gene encodes a nuclear protein with both helicase and exonuclease activities. While individuals with WS have mutations that result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f562829d79060536976536a5266c4ff
https://doi.org/10.1016/j.mad.2004.05.001
https://doi.org/10.1016/j.mad.2004.05.001
Autor:
Cayetano von Kobbe, Patricia L. Opresko, Vilhelm A. Bohr, Michael M. Seidman, Wen-Hsing Cheng, L. Matthew Arthur, Kenshi Komatsu, James P. Carney
Publikováno v:
Journal of Biological Chemistry. 279:21169-21176
The Werner syndrome and the Nijmegen breakage syndrome are recessive genetic disorders that show increased genomic instability, cancer predisposition, hypersensitivity to mitomycin C and gamma-irradiation, shortened telomeres, and cell cycle defects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198e960b80747d69a747e45ceb1b1052
https://doi.org/10.1074/jbc.m312770200
https://doi.org/10.1074/jbc.m312770200