Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Cayetano Pleguezuelos Manzano"'
Autor:
Carla Pou Casellas, Cayetano Pleguezuelos-Manzano, Maarten B. Rookmaaker, Marianne C. Verhaar, Hans Clevers
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Single-cell RNA sequencing has recently led to the identification of a flurry of rare, new cell types, such as the CFTR-high ionocytes in the airway epithelium. Ionocytes appear to be specifically responsible for fluid osmolarity and pH regu
Externí odkaz:
https://doaj.org/article/c87fad1e558047af81e4a39f6de2362b
Autor:
Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J. Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epitheli
Externí odkaz:
https://doaj.org/article/95c7a12eb075491590066e174053f556
Autor:
Joep Beumer, Maarten H. Geurts, Mart M. Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart, Anna Z. Mykytyn, Tim I. Breugem, Samra Riesebosch, Debby Schipper, Petra B. van den Doel, Wim de Lau, Cayetano Pleguezuelos-Manzano, Georg Busslinger, Bart L. Haagmans, Hans Clevers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology a
Externí odkaz:
https://doaj.org/article/1db487b66712463886d067b96ac47dba
Autor:
Carla Pou Casellas, Cayetano Pleguezuelos-Manzano, Maarten B. Rookmaaker, Marianne C. Verhaar, Hans Clevers
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/e2746c1a6b594133b9e72bf4b5ad2396
Autor:
Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M. O’Hagan, Hao Wang, Ruben van Boxtel, Hans Clevers, Cynthia L. Sears
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mut
Externí odkaz:
https://doaj.org/article/c8b925b4810c4dcabf9cb25d68e6536b
Autor:
Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Léveillé, Nina E. de Groot, Andrew N. Holding, Florian Markowetz, Louis Vermeulen
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early mutation leading to such
Externí odkaz:
https://doaj.org/article/eadd93dc5c0b4df5ab1fbd8979ed785d
Publikováno v:
Annual Review of Cancer Biology. 6:65-84
Colorectal cancer (CRC) is associated with the presence of particular gut microbes, as observed in many metagenomic studies to date. However, in most cases, it remains difficult to disentangle their active contribution to CRC from just a bystander ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2671e8c52641e7eef63871800f494f0d
https://doi.org/10.1146/annurev-cancerbio-070120-095211
https://doi.org/10.1146/annurev-cancerbio-070120-095211
Autor:
Cayetano Pleguezuelos-Manzano, Wouter A. G. Beenker, Gijs J.F. van Son, Harry Begthel, Gimano D. Amatngalim, Jeffrey M. Beekman, Hans Clevers, Jeroen den Hertog
Pseudomonas aeruginosais a Gram-negative bacterium that is notorious for infections in the airway of cystic fibrosis (CF) subjects. Often, these infections become chronic, leading to higher morbidity and mortality rates. Bacterial quorum sensing (QS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70252956fe59e43894e1e0b958ac764d
https://doi.org/10.1101/2023.03.11.532178
https://doi.org/10.1101/2023.03.11.532178
Autor:
Inha Heo, Hans Clevers, Ninouk Akkerman, Adriana Martinez-Silgado, Aurelia Saftien, Cayetano Pleguezuelos-Manzano, Charelle Boot, Joep Beumer, Amy de Waal, Devanjali Dutta, Jens Puschhof
Publikováno v:
Nature Protocols. 16(10):4633-4649
Adult-stem-cell-derived organoids model human epithelial tissues ex vivo, which enables the study of host–microbe interactions with great experimental control. This protocol comprises methods to coculture organoids with microbes, particularly focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418e4d13fe69c8463d29d7970bf1dda6
https://doi.org/10.1038/s41596-021-00589-z
https://doi.org/10.1038/s41596-021-00589-z
Autor:
Arne Van Hoeck, Jens Puschhof, Axel Rosendahl Huber, Ruben van Boxtel, Reinier van der Linden, Fernanda L. Paganelli, K. Christopher Garcia, Stefan van der Elst, Matthew Meyerson, Hans Clevers, Guillaume Dalmasso, Marios Giannakis, Richard Bonnet, Paul B. Stege, Phil Quirke, Tomohiro Mizutani, Henry M. Wood, Edwin Cuppen, Rob J. L. Willems, Maarten H. Geurts, Carino Gurjao, Cayetano Pleguezuelos-Manzano, Joep Beumer, Freek Manders, Yi Miao, Janetta Top, Jason Nomburg
Publikováno v:
Nature
Nature, Nature Publishing Group, 2020, 580 (7802), pp.269-273. ⟨10.1038/s41586-020-2080-8⟩
Nature, 580(7802), 269-273. Nature Publishing Group
Nature, Nature Publishing Group, 2020, 580 (7802), pp.269-273. ⟨10.1038/s41586-020-2080-8⟩
Nature, 580(7802), 269-273. Nature Publishing Group
International audience; Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Esch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea03f3d630c47a9677c25c397bbf599
https://doi.org/10.1038/s41586-020-2080-8
https://doi.org/10.1038/s41586-020-2080-8