Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Cay M. Kielty"'
Autor:
Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J. Rothwell, Cay M. Kielty, Stuart M. Allan, Emmanuel Pinteaux
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)
Abstract Background Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to only a minority of pa
Externí odkaz:
https://doaj.org/article/17a516f6e4c24ba9a4a4c740dfdb4cea
Autor:
Rebecca J. Holley, Guangping Tai, Andrew J.K. Williamson, Samuel Taylor, Stuart A. Cain, Stephen M. Richardson, Catherine L.R. Merry, Anthony D. Whetton, Cay M. Kielty, Ann E. Canfield
Publikováno v:
Stem Cell Reports, Vol 4, Iss 3, Pp 473-488 (2015)
Mesenchymal progenitor cells have great therapeutic potential, yet incomplete characterization of their cell-surface interface limits their clinical exploitation. We have employed subcellular fractionation with quantitative discovery proteomics to de
Externí odkaz:
https://doaj.org/article/6cc71db326e54606a55143823a1d825d
Autor:
Michael P. Lockhart-Cairns, Stuart A. Cain, Rana Dajani, Ruth Steer, Jennifer Thomson, Yasmene F. Alanazi, Cay M. Kielty, Clair Baldock
Publikováno v:
Lockhart, M, Cain, S, Dajani, R, Steer, R, Thomson, J, Alanazi, Y F, Kielty, C & Baldock, C 2022, ' Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation ', Matrix Biology, vol. 107, pp. 24-39 . https://doi.org/10.1016/j.matbio.2022.01.005
'Matrix Biology ', vol: 107, pages: 24-39 (2022)
'Matrix Biology ', vol: 107, pages: 24-39 (2022)
TGFβ superfamily members are potent growth factors in the extracellular matrix with essential roles in all aspects of cellular behaviour. Latent TGFβ binding proteins (LTBPs) are co-expressed with TGFβ, essential for correct folding and secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3226c3baac5095cff2949a92db97fb8
https://www.research.manchester.ac.uk/portal/en/publications/latent-tgf-complexes-are-transglutaminase-crosslinked-to-fibrillin-to-facilitate-tgf-activation(686af532-eb01-413a-a2ba-53e3b30dd24f).html
https://www.research.manchester.ac.uk/portal/en/publications/latent-tgf-complexes-are-transglutaminase-crosslinked-to-fibrillin-to-facilitate-tgf-activation(686af532-eb01-413a-a2ba-53e3b30dd24f).html
Autor:
Caroline M. Milner, Anthony J. Day, Holly L. Birchenough, Alexander W.W. Langford-Smith, Jan J. Enghild, Clair Baldock, Cay M. Kielty, David Briggs, Thomas A. Jowitt
Publikováno v:
The Journal of Biological Chemistry
The journal of biological chemistry 295(16), 5278-5291 (2020). doi:10.1074/jbc.RA119.011916
Briggs, D C, Langford-Smith, A W W, Birchenough, H L, Jowitt, T A, Kielty, C M, Enghild, J J, Baldock, C, Milner, C M & Day, A J 2020, ' Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation ', The Journal of Biological Chemistry, vol. 295, no. 16, pp. 5278-5291 . https://doi.org/10.1074/jbc.RA119.011916, https://doi.org/10.1074/jbc.RA119.011916
The journal of biological chemistry 295(16), 5278-5291 (2020). doi:10.1074/jbc.RA119.011916
Briggs, D C, Langford-Smith, A W W, Birchenough, H L, Jowitt, T A, Kielty, C M, Enghild, J J, Baldock, C, Milner, C M & Day, A J 2020, ' Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation ', The Journal of Biological Chemistry, vol. 295, no. 16, pp. 5278-5291 . https://doi.org/10.1074/jbc.RA119.011916, https://doi.org/10.1074/jbc.RA119.011916
Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous "heavy chains" (HC1 and HC2) covalently attached to chondroitin sulfate on the bikuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28df7b8d02605e03fd8835caf3cca795
https://pubmed.ncbi.nlm.nih.gov/32144206
https://pubmed.ncbi.nlm.nih.gov/32144206
Autor:
Anthony J. Day, Alex Langford-Smith, Jan J. Enghild, Thomas A. Jowitt, Caroline M. Milner, Cay M. Kielty, David Briggs, Clair Baldock
Inter-α-inhibitor (IαI) is a proteoglycan essential for mammalian reproduction that also plays a less well-characterised role in inflammation. IαI is composed of 2 homologous ‘heavy chains’ (HC1 and HC2) covalently attached to chondroitin sulp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e907105f7793b42e00b0821d6ab9cb80
https://doi.org/10.1101/695700
https://doi.org/10.1101/695700
Autor:
Patricia Keith, Valérie Cormier-Daire, Christine Bole-Feysot, Carine Le Goff, Tony J. Kenna, Aideen M. McInerney-Leo, Cay M. Kielty, Emma L. Duncan, Paul Leo, Ruth Steer, Patrick Nitschke, Andreas Zankl, Jessica Harris, Matthew A. Brown
Publikováno v:
Journal of Medical Genetics. 53:457-464
Background Acromelic dysplasias are a group of disorders characterised by short stature, brachydactyly, limited joint extension and thickened skin and comprises acromicric dysplasia (AD), geleophysic dysplasia (GD), Myhre syndrome and Weill–Marches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7ed5edcd4aa3abed2ebdcf42e7fe2e
https://doi.org/10.1136/jmedgenet-2015-103647
https://doi.org/10.1136/jmedgenet-2015-103647
Autor:
E.J. Mularczyk, Neil E. Humphreys, Mukti Singh, Raymond P. Boot-Handford, Antony Adamson, Alan R.F. Godwin, Cay M. Kielty, Giulio Cossu, Gerhard Sengle, Clair Baldock, Alexander A. Mironov, Francesco Galli, Stuart A. Cain
Publikováno v:
Mularczyk, E, Singh, M, Godwin, A, Galli, F, Humphreys, N, Adamson, A, Mironov, A, Cain, S, Sengle, G, Boot-Handford, R, Cossu, G, Kielty, C & Baldock, C 2018, ' ADAMTS10-mediated tissue disruption in Weill-Marchesani Syndrome ', Human Molecular Genetics, vol. 27, no. 21, pp. 3675-3687 . https://doi.org/10.1093/hmg/ddy276
Human Molecular Genetics
Human Molecular Genetics
Fibrillin microfibrils are extracellular matrix assemblies that form the template for elastic fibres, endow blood vessels, skin and other elastic tissues with extensible properties. They also regulate the bioavailability of potent growth factors of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5397bb4d7f8070b533bc6c39ba00ae64
https://www.research.manchester.ac.uk/portal/en/publications/adamts10mediated-tissue-disruption-in-weillmarchesani-syndrome(118b7468-bb72-403e-8401-08e563f24940).html
https://www.research.manchester.ac.uk/portal/en/publications/adamts10mediated-tissue-disruption-in-weillmarchesani-syndrome(118b7468-bb72-403e-8401-08e563f24940).html
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1722
We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::252c79cfa73c19e8575d8c0c2276e860
https://pubmed.ncbi.nlm.nih.gov/29264810
https://pubmed.ncbi.nlm.nih.gov/29264810
Autor:
Mariarosa Mazza, Neus Lozano, Maurizio Buggio, Kostas Kostarelos, Cay M. Kielty, Débora B Vieira
Publikováno v:
Mazza, M, Lozano Valdes, M D L N, Braga Vieira, D, Buggio, M, Kielty, C & Kostarelos, K 2017, ' Liposome-Indocyanine Green Nanoprobes for Optical Labeling and Tracking of Human Mesenchymal Stem Cells Post-Transplantation In Vivo ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201700374
Direct labeling of human mesenchymal stem cells (hMSC) prior to transplantation provides a means to track cells after administration and it is a powerful tool for the assessment of new cell-based therapies. Biocompatible nanoprobes consisting of lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2ead7ea1bee995d1091c3df64f0b2f
https://pubmed.ncbi.nlm.nih.gov/28777501
https://pubmed.ncbi.nlm.nih.gov/28777501
Autor:
Andreas Superti-Furga, Siddharth Banka, Günhan Erdem, Helen Kingston, Bronwyn Kerr, William G. Newman, Sabrya Carim, Michelle Bottomley, Ariane L. Herrick, Sheila Unger, Sarah B. Daly, Cay M. Kielty, Jane Worthington, Jade Harris, Dian Donnai, Wyatt W. Yue, Catherine L.R. Merry, Holly Ennis, Jill E. Urquhart, Stuart A. Cain
Publikováno v:
Europe PubMed Central
ObjectivesLeri’s pleonosteosis (LP) is an autosomal dominant rheumatic condition characterised by flexion contractures of the interphalangeal joints, limited motion of multiple joints, and short broad metacarpals, metatarsals and phalanges. Sclerod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf636026683a2199e05250c2add5641d
https://doi.org/10.1136/annrheumdis-2013-204309
https://doi.org/10.1136/annrheumdis-2013-204309