Výsledky vyhledávání - "Cay M. Kielty"

Akademický článek

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

Autor: Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J. Rothwell, Cay M. Kielty, Stuart M. Allan, Emmanuel Pinteaux

Publikováno v: Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)

Abstract Background Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to only a minority of pa

Externí odkaz: https://doaj.org/article/17a516f6e4c24ba9a4a4c740dfdb4cea

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Akademický článek

Comparative Quantification of the Surfaceome of Human Multipotent Mesenchymal Progenitor Cells

Autor: Rebecca J. Holley, Guangping Tai, Andrew J.K. Williamson, Samuel Taylor, Stuart A. Cain, Stephen M. Richardson, Catherine L.R. Merry, Anthony D. Whetton, Cay M. Kielty, Ann E. Canfield

Publikováno v: Stem Cell Reports, Vol 4, Iss 3, Pp 473-488 (2015)

Mesenchymal progenitor cells have great therapeutic potential, yet incomplete characterization of their cell-surface interface limits their clinical exploitation. We have employed subcellular fractionation with quantitative discovery proteomics to de

Externí odkaz: https://doaj.org/article/6cc71db326e54606a55143823a1d825d

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Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation

Autor: Michael P. Lockhart-Cairns, Stuart A. Cain, Rana Dajani, Ruth Steer, Jennifer Thomson, Yasmene F. Alanazi, Cay M. Kielty, Clair Baldock

Publikováno v: Lockhart, M, Cain, S, Dajani, R, Steer, R, Thomson, J, Alanazi, Y F, Kielty, C & Baldock, C 2022, ' Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation ', Matrix Biology, vol. 107, pp. 24-39 . https://doi.org/10.1016/j.matbio.2022.01.005
'Matrix Biology ', vol: 107, pages: 24-39 (2022)

TGFβ superfamily members are potent growth factors in the extracellular matrix with essential roles in all aspects of cellular behaviour. Latent TGFβ binding proteins (LTBPs) are co-expressed with TGFβ, essential for correct folding and secretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3226c3baac5095cff2949a92db97fb8
https://www.research.manchester.ac.uk/portal/en/publications/latent-tgf-complexes-are-transglutaminase-crosslinked-to-fibrillin-to-facilitate-tgf-activation(686af532-eb01-413a-a2ba-53e3b30dd24f).html

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Akademický článek

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

Autor: Stuart A Cain, Amanda McGovern, Andrew K Baldwin, Clair Baldock, Cay M Kielty

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48634 (2012)

The extracellular glycoprotein fibrillin-1 forms microfibrils that act as the template for elastic fibers. Most mutations in fibrillin-1 cause Marfan syndrome with severe cardiovascular and ocular symptoms, and tall stature. This is in contrast to mu

Externí odkaz: https://doaj.org/article/bd46809b203b494e957b5b6b6b9ce22b

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Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation

Autor: Caroline M. Milner, Anthony J. Day, Holly L. Birchenough, Alexander W.W. Langford-Smith, Jan J. Enghild, Clair Baldock, Cay M. Kielty, David Briggs, Thomas A. Jowitt

Publikováno v: The Journal of Biological Chemistry
The journal of biological chemistry 295(16), 5278-5291 (2020). doi:10.1074/jbc.RA119.011916
Briggs, D C, Langford-Smith, A W W, Birchenough, H L, Jowitt, T A, Kielty, C M, Enghild, J J, Baldock, C, Milner, C M & Day, A J 2020, ' Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation ', The Journal of Biological Chemistry, vol. 295, no. 16, pp. 5278-5291 . https://doi.org/10.1074/jbc.RA119.011916, https://doi.org/10.1074/jbc.RA119.011916

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous "heavy chains" (HC1 and HC2) covalently attached to chondroitin sulfate on the bikuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28df7b8d02605e03fd8835caf3cca795
https://pubmed.ncbi.nlm.nih.gov/32144206

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Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities

Autor: Anthony J. Day, Alex Langford-Smith, Jan J. Enghild, Thomas A. Jowitt, Caroline M. Milner, Cay M. Kielty, David Briggs, Clair Baldock

Inter-α-inhibitor (IαI) is a proteoglycan essential for mammalian reproduction that also plays a less well-characterised role in inflammation. IαI is composed of 2 homologous ‘heavy chains’ (HC1 and HC2) covalently attached to chondroitin sulp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e907105f7793b42e00b0821d6ab9cb80
https://doi.org/10.1101/695700

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Mutations inLTBP3cause acromicric dysplasia and geleophysic dysplasia

Autor: Patricia Keith, Valérie Cormier-Daire, Christine Bole-Feysot, Carine Le Goff, Tony J. Kenna, Aideen M. McInerney-Leo, Cay M. Kielty, Emma L. Duncan, Paul Leo, Ruth Steer, Patrick Nitschke, Andreas Zankl, Jessica Harris, Matthew A. Brown

Publikováno v: Journal of Medical Genetics. 53:457-464

Background Acromelic dysplasias are a group of disorders characterised by short stature, brachydactyly, limited joint extension and thickened skin and comprises acromicric dysplasia (AD), geleophysic dysplasia (GD), Myhre syndrome and Weill–Marches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7ed5edcd4aa3abed2ebdcf42e7fe2e
https://doi.org/10.1136/jmedgenet-2015-103647

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ADAMTS10-mediated tissue disruption in Weill-Marchesani Syndrome

Autor: E.J. Mularczyk, Neil E. Humphreys, Mukti Singh, Raymond P. Boot-Handford, Antony Adamson, Alan R.F. Godwin, Cay M. Kielty, Giulio Cossu, Gerhard Sengle, Clair Baldock, Alexander A. Mironov, Francesco Galli, Stuart A. Cain

Publikováno v: Mularczyk, E, Singh, M, Godwin, A, Galli, F, Humphreys, N, Adamson, A, Mironov, A, Cain, S, Sengle, G, Boot-Handford, R, Cossu, G, Kielty, C & Baldock, C 2018, ' ADAMTS10-mediated tissue disruption in Weill-Marchesani Syndrome ', Human Molecular Genetics, vol. 27, no. 21, pp. 3675-3687 . https://doi.org/10.1093/hmg/ddy276
Human Molecular Genetics

Fibrillin microfibrils are extracellular matrix assemblies that form the template for elastic fibres, endow blood vessels, skin and other elastic tissues with extensible properties. They also regulate the bioavailability of potent growth factors of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5397bb4d7f8070b533bc6c39ba00ae64
https://www.research.manchester.ac.uk/portal/en/publications/adamts10mediated-tissue-disruption-in-weillmarchesani-syndrome(118b7468-bb72-403e-8401-08e563f24940).html

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Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow

Autor: Teresa, Massam-Wu, Stuart A, Cain, Cay M, Kielty

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1722

We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::252c79cfa73c19e8575d8c0c2276e860
https://pubmed.ncbi.nlm.nih.gov/29264810

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Liposome-Indocyanine Green Nanoprobes for Optical Labeling and Tracking of Human Mesenchymal Stem Cells Post-Transplantation In Vivo

Autor: Mariarosa Mazza, Neus Lozano, Maurizio Buggio, Kostas Kostarelos, Cay M. Kielty, Débora B Vieira

Publikováno v: Mazza, M, Lozano Valdes, M D L N, Braga Vieira, D, Buggio, M, Kielty, C & Kostarelos, K 2017, ' Liposome-Indocyanine Green Nanoprobes for Optical Labeling and Tracking of Human Mesenchymal Stem Cells Post-Transplantation In Vivo ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201700374

Direct labeling of human mesenchymal stem cells (hMSC) prior to transplantation provides a means to track cells after administration and it is a powerful tool for the assessment of new cell-based therapies. Biocompatible nanoprobes consisting of lipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2ead7ea1bee995d1091c3df64f0b2f
https://pubmed.ncbi.nlm.nih.gov/28777501

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