BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming.

Autor: Sevinç K; School of Medicine, Koç University, Istanbul, Turkey., Sevinç GG; School of Medicine, Koç University, Istanbul, Turkey., Cavga AD; School of Medicine, Koç University, Istanbul, Turkey; Biostatistics, Bioinformatics and Data Management Core, KUTTAM, Koç University, Istanbul, Turkey., Philpott M; Botnar Research Centre, Oxford NIHR BRU, University of Oxford, Oxford, UK., Kelekçi S; School of Medicine, Koç University, Istanbul, Turkey., Can H; School of Medicine, Koç University, Istanbul, Turkey., Cribbs AP; Botnar Research Centre, Oxford NIHR BRU, University of Oxford, Oxford, UK., Yıldız AB; School of Medicine, Koç University, Istanbul, Turkey., Yılmaz A; School of Medicine, Koç University, Istanbul, Turkey., Ayar ES; School of Medicine, Koç University, Istanbul, Turkey., Arabacı DH; School of Medicine, Koç University, Istanbul, Turkey., Dunford JE; Botnar Research Centre, Oxford NIHR BRU, University of Oxford, Oxford, UK., Ata D; School of Medicine, Koç University, Istanbul, Turkey., Sigua LH; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA., Qi J; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA., Oppermann U; Botnar Research Centre, Oxford NIHR BRU, University of Oxford, Oxford, UK; Centre for Medicine Discovery, University of Oxford, Oxford, UK; Oxford Centre for Translational Myeloma Research, University of Oxford, Oxford OX3 7LD, UK., Onder TT; School of Medicine, Koç University, Istanbul, Turkey. Electronic address: tonder@ku.edu.tr.

Publikováno v: Stem cell reports [Stem Cell Reports] 2022 Dec 13; Vol. 17 (12), pp. 2629-2642. Date of Electronic Publication: 2022 Nov 03.

Development of 2-(5,6,7-Trifluoro-1 H -Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer.

Autor: Leblanc E; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Ban F; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Cavga AD; School of Medicine, Koç University, Rumelifeneri Yolu, Istanbul 34450, Turkey., Lawn S; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Huang CF; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Mohan S; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada., Chang MEK; Knight Cancer Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97239, United States., Flory MR; Knight Cancer Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97239, United States., Ghaidi F; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Lingadahalli S; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Chen G; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada., Yu IPL; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Morin H; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Lallous N; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Gleave ME; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Mohammed H; Knight Cancer Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97239, United States., Young RN; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada., Rennie PS; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada., Lack NA; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.; School of Medicine, Koç University, Rumelifeneri Yolu, Istanbul 34450, Turkey., Cherkasov A; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Oct 28; Vol. 64 (20), pp. 14968-14982. Date of Electronic Publication: 2021 Oct 18.

Differential expression of full-length and NH 2 terminally truncated FAM134B isoforms in normal physiology and cancer.

Autor: Keles U; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey., Iscan E; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey., Yilmaz HE; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey., Karakülah G; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey., Suner A; Department of Biostatistics and Medical Informatics, Ege University, Izmir, Turkey., Bal E; Izmir Biomedicine and Genome Center, Izmir, Turkey., Tasdemir N; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey., Cavga AD; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey., Ekin U; Izmir Biomedicine and Genome Center, Izmir, Turkey.; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey., Mutlu Z; Izmir Biomedicine and Genome Center, Izmir, Turkey., Kahyaoglu S; Izmir Biomedicine and Genome Center, Izmir, Turkey., Serdar MA; Department of Biochemistry, Acıbadem University, İstanbul, Turkey., Atabey N; Izmir Biomedicine and Genome Center, Izmir, Turkey., Ozturk M; Izmir Biomedicine and Genome Center, Izmir, Turkey.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2020 Dec 01; Vol. 319 (6), pp. G733-G747. Date of Electronic Publication: 2020 Oct 14.

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

Autor: Pooley JR; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom.; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Rivers CA; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom., Kilcooley MT; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom., Paul SN; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom., Cavga AD; Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey., Kershaw YM; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom., Muratcioglu S; Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America.; Howard Hughes Medical Institute, University of California, Berkeley, California, United States of America., Gursoy A; Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey., Keskin O; Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey., Lightman SL; Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom.

Publikováno v: PloS one [PLoS One] 2020 Jan 10; Vol. 15 (1), pp. e0227520. Date of Electronic Publication: 2020 Jan 10 (Print Publication: 2020).

Taming Oncogenic Signaling at Protein Interfaces: Challenges and Opportunities.

Autor: Cavga AD, Karahan N, Keskin O, Gursoy A; College of Engineering, Koc University, Rumelifeneri Yolu, 34450 Sariyer Istanbul, Istanbul, Turkey. agursoy@ku.edu.tr.

Publikováno v: Current topics in medicinal chemistry [Curr Top Med Chem] 2015; Vol. 15 (20), pp. 2005-18.