Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

Autor: D'Amelio M. 1, 2, Cavallucci V. 1, Middei S. 3, Marchetti C. 4, Pacioni S. 5, Ferri A. 6, Diamantini A. 7, De Zio D.8, Carrara P.9, Battistini L.7, Moreno S.9, Bacci A.5, Ammassari-Teule M.3, Marie H.4, Cecconi F.1, 8

Publikováno v: Nature neuroscience
14(1) (2011): 69–76.
info:cnr-pdr/source/autori:D'Amelio M. 1,2, Cavallucci V. 1, Middei S. 3, Marchetti C. 4, Pacioni S. 5, Ferri A. 6, Diamantini A. 7, De Zio D.8, Carrara P.9, Battistini L.7, Moreno S.9, Bacci A.5, Ammassari-Teule M.3, Marie H.4, Cecconi F.1,8/titolo:Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease/doi:/rivista:Nature neuroscience (Print)/anno:2011/pagina_da:69/pagina_a:76/intervallo_pagine:69–76/volume:14(1)

Synaptic loss is the best pathological correlate of the cognitive decline in Alzheimer's disease; however, the molecular mechanisms underlying synaptic failure are unknown. We found a non-apoptotic baseline caspase-3 activity in hippocampal dendritic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::a952d10fc50ea113b3d1ff6992af4453
https://publications.cnr.it/doc/59318