Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ.

Autor: Ding L; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Su Y; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Deciphera Pharmaceuticals, Waltham, MA, USA., Fassl A; Department of Cancer Biology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA., Hinohara K; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Nagoya University Graduate School of Medicine, Nagoya, Japan., Qiu X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Harper NW; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA., Huh SJ; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; ImmunoGen, Inc, Waltham, MA, USA., Bloushtain-Qimron N; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; EMEA Site Intelligence and Activation, Tel Aviv, Israel., Jovanović B; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Ekram M; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; WuXi NextCODE, Cambridge, MA, USA., Zi X; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA.; Second Military Medical University, Shanghai, 200433, P.R. China., Hines WC; Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; University of New Mexico School of Medicine, Albuquerque, NM, USA., Alečković M; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Gil Del Alcazar C; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Caulfield RJ; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA., Bonal DM; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA., Merino VF; Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Choudhury S; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Metamark Genetics Inc, Worcester, MA, USA., Ethington G; Baylor-Charles A. Sammons Cancer Center, Dallas, TX, 75246, USA., Panos L; Baylor-Charles A. Sammons Cancer Center, Dallas, TX, 75246, USA., Grant M; Baylor-Charles A. Sammons Cancer Center, Dallas, TX, 75246, USA., Herlihy W; Baylor-Charles A. Sammons Cancer Center, Dallas, TX, 75246, USA., Au A; University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94143, USA., Rosson GD; Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Argani P; Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Richardson AL; Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Pathology, Harvard Medical School, Boston, MA, 02115, USA.; Johns Hopkins Medical Institutions, Baltimore, MD, USA., Dillon D; Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Pathology, Harvard Medical School, Boston, MA, 02115, USA., Allred DC; Department of Pathology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Babski K; Sutter Roseville Medical Center, Roseville, CA, 95661, USA., Kim EMH; Sutter Roseville Medical Center, Roseville, CA, 95661, USA.; Cancer Treatment Centers of America, Atlanta, GA, USA., McDonnell CH 3rd; Sutter Roseville Medical Center, Roseville, CA, 95661, USA., Wagner J; Sutter Roseville Medical Center, Roseville, CA, 95661, USA., Rowberry R; Sutter Roseville Medical Center, Roseville, CA, 95661, USA., Bobolis K; Sutter Roseville Medical Center, Roseville, CA, 95661, USA., Kleer CG; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Hwang ES; University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94143, USA.; Duke University, Durham, NC, USA., Blum JL; Baylor-Charles A. Sammons Cancer Center, Dallas, TX, 75246, USA., Cristea S; Department of Data Science, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health Boston, Boston, MA, 02215, USA.; Department of Stem Cell and Regenerative Biology, Harvard University Cambridge, Cambridge, MA, 02138, USA., Sicinski P; Department of Cancer Biology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA., Fan R; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA., Long HW; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Sukumar S; Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Park SY; Department of Pathology, Seoul National University College of Medicine, Seoul, Korea., Garber JE; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Bissell M; Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Yao J; MD Anderson Cancer Center, Houston, TX, 77030, USA., Polyak K; Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Boston, MA, 02215, USA. Kornelia_Polyak@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. Kornelia_Polyak@dfci.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA. Kornelia_Polyak@dfci.harvard.edu.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. Kornelia_Polyak@dfci.harvard.edu.; Harvard Stem Cell Institute, Cambridge, MA, 02138, USA. Kornelia_Polyak@dfci.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 13; Vol. 10 (1), pp. 4182. Date of Electronic Publication: 2019 Sep 13.