Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Caudiu Trandafir Supuran"'
Autor:
Johan Wouters, Raphaël Frédérick, Caudiu Trandafir Supuran, Bernard Masereel, Anne Thiry, Jean-Michel Dogné, Marie Ledecq, Alessandro Cecchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:553-557
A three-dimensional pharmacophore model of CA IX inhibitors was generated and used to screen the ZINC database of commercially available compounds. The hits were docked in a CA IX homology model. By visualizing the binding mode and score of these com
Autor:
A. Di Fiore, Simona Maria Monti, V. Alterio, Jekaterina Ivanova, Raivis Zalubovskis, G. De Simone, Caudiu Trandafir Supuran, Muhammet Tanc, I. V. Vozny
Publikováno v:
Organicbiomolecular chemistry. 13(13)
6-Sulfamoyl-saccharin was investigated as an inhibitor of 11 α-carbonic anhydrase (CA, EC 4.2.1.1) isoforms of human (h) origin, hCA I-XIV, and X-ray crystallographic data were obtained for its adduct with hCA II, the physiologically dominant isofor