Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trialResearch in context

Autor: Andrea Alemany, Pere Millat-Martinez, Marc Corbacho-Monné, Clara Suñer, Cristina Galvan-Casas, Caty Carrera, Dan Ouchi, Núria Prat, Jordi Ara, Nuria Nadal, Ricard Riel, Blanca Funollet, Carmen Ojeda-Ciurana, Lluis Esteve Balague, Betlem Salvador-González, Anna Forcada Arcarons, Josep Vidal-Alaball, María Isabel Del Cura-González, Ricardo Rodríguez Barrientos, Rafel Ramos-Blanes, Alberto Alum Bou, Elsa Mondou, Mireia Torres, Neus Campins, Ana Sanz, Yonggiang Tang, Miquel Àngel Rodriguez-Arias, Quique Bassat, Bonaventura Clotet, Oriol Mitjà, Adrià Aguilar-Uroz, Adrià Rosell-García-Ufano, Adrián Escudero Planas, Aida Baelo, Ainhoa Villahoz Martín, Alberto Moreno López, Alberto Roldan Ruiz, Alberto Santana Briongos, Alberto Tejera Bodas, Alejandro Alonso-Vallés, Alejandro Fletes-Pérez, Alejandro Hueso-Mor, Alex Boluda, Alex Santamaria, Alicia Santos Diestro, Almudena Revuelta-Álvarez, Álvaro Moreno Moreno, Ana Ortega de Felipe, Ana Chen-Ye, Ana Blázquez Valerón, Ana Belén Rodríguez Pérez, Ana Laura Tristán Morgalo, Ana Luisa Fernández-Allende, Andrea Bagán-Trejo, Andrés Fernández Juan, Ángel Zalve-Cano, Anna Mateo-Martínez, Antonio Valero Galván, Antonio Egidos-Plaja, Ariadna Jorge, Arturo Fraile Torres, Azahara Maria Pareja Leal, Bárbara Viader Castro, Barbara Fernandez Beato, Barbara Naveira Menchen, Beatriz Martin Poyatos, Beatriz García-Martínez, Belén Rodrigo Testillano, Belen Blanco Tejedor, Blanca López Pérez, Blanca Mencía Hernanz, Camila González-Beiras, Carlos Batres, Carmen Nuñez Garcia, Carmen Merino-Rodríguez, Carolina Rodríguez-Gilabert, Celia Bonilla Penedo, Christian Casado Gomez, Claudia Gonzalez Perez, Claudia Galindo-Tomás, Cristina Peral Bolaños, Cristina Blanco-Montes, Cristina Lupu-Yakovleva, Cristina Lopez Ruiz, Cristina Perez Mayoral, Cristina Fornes, Cristobal Garcia Corrochano, Daniel Gallardo Álvarez, Daniel Navarro Sanz, David Sanz Barrio, Debora Ramet Meseguer, Edna Margarita Vera-Jurado, Eduardo Perez Costa, Eilen Junet Bustillos-Sebastian, Elena Palomar Casado, Elena Dorrego Guerrero, Elena Medina Mateos, Elisa Rebeca Aragón Gaspar, Elisabeth Herrero-Vila, Enriqueta Paez Herrera, Esmeralda Rojas Powel, Esther Robres Medialdea, Esther Vall-Ribalta, Eva Lopez Perez, Felicia Mihaela Fer, Fernanda Vazquez Ángeles, Fernando Tirado Bejarano, Ferran Prats-Domenech, Ferran Borràs Martí, Gabriela Ardila-Mejia, Gèlia Costes, Gema Gómez Arquero, Gemma Flores Mateo, Guillem Pintos-Morell, Helena Mira-Centelles, Ignacio Astola Requena, Ignacio Ortega Martin, Iker Leivas-Gutierrez, Irene Escribano Valenciano, Irene Muñoz Gomez, Irina Ortega, Isabel Montserrat-Lloan, Itziar Gamboa, Jacobo Rodríguez de Torres de Paul, Jordi Cahís, Jordi Muñoz-Martinez, Jorge Iglesias Bermejo, Joselvis Virginia Cejas López, Josep Canudas, Juan Antonio García Lucas, Juan Carlos Martínez-Pino, Juana Torres Martínez, Judit Pujol-Corney, Judith González Jiménez, Júlia Gurí, Julio Labella Martín, Laia Garcia-Cano, Lara Sonsoles Perez Plata, Laura Muñoz Álvaro, Laura Rodríguez Andrés, Laura Vega Ruiz, Laura Cuevas Valiente, Laura Díaz Rodríguez, Laura Puigros, Lavinia Oristina Rciorang, Leticia Escudero, Liliana Figueroa Caballero, Lluna Ferrerfàbrega-Costals, Lucía Costafreda-Hernández, Lucía De-Paúl, Luis González Fernández-Medina, Ma Carmen Moliner Prada, Ma Cristina Berriochoa Martínez de Pisón, Maria Blanco Blasco, Maria Gil Jorge, María Cortijo Caballero, Maria Ubals, Maria Gordillo, Maria Alicia Guilloto López, Maria Concepción Moreno Calvo, María del Rosario Gil García, María Inmaculada Dueñas Román, Maria Josefa Gonzalez Sanchez, María Luisa Nicolás Campoy, Maria Luz González Velayos, Mario Mejías Zori, Mario Oliva Maqueda, Mario Caño de la Cruz, Mariona Palau-Morral, Marta Martín-Muñoz, Marta Cereceda Meca, Marta Díaz Urbina, Martha VerónicaPlazas, Martí Vall-Mayans, Martí Blasco, Mary Jane Chu-Sifuentes, Miguel García de Villasladad Peñaranda, Miguel Hernanz Sotoca, Miguel Iglesias Gonzalez, Miguel Ángel Labrador-Galván, Miguel Rodrigo de Vivar Azcarate, Miquel Gil-Fibla, Miquel Formentí-Pallarés, Mireia Esteve-Tugues, Miriam Juanes Perez, Miriam López Rubio, Mirian Recuero Renales, Mònica Hijós-Rullo, Montserrat Lleonart-Abadia, Nadia Finelli, Naiara Rojas-Bertier, Nataly Reyes-Calderón, Nerea Casado Larrañaga, Nerea Nuria Zurita Castrosin, Noélia Álvarez-Nieto, Nuria Leiva-Mora, Olga Tomillo-Martín, Omar Belghazi, Oriol Buscà, Pablo Mendoza Cediel, Pablo Macedo, Patricia Rodríguez Barroso, Patricia Ruiz Álvarez, Patricia Morales López, Patricia Jimenez Vara de Rey, Paz Lozano Ginés, Pilar Bris Rodriguez, Pilar Martínez-Alamillo, Rafa Salmerón Martínez, Raquel Botello Ariza, Raquel Vaquero Mena, Raquel González-Alonso, Raul Kaczmarczyk, Rita Barnadas Vintró, Rodrigo Hontecillas Martínez, Rosa Ribot-Rodríguez, Rosa Escobar-Sánchez, Rosario Paloma Montes Trinidad, Rubén Martínez Quintana, Ruben Arnay Arrogante, Ruben Berjon Sanchez, Ruben Picazo Navarro, Rubén Bastos, Samuel Martín Molinero, Samuel Dan Israel-Benchaya, Sandra Muñoz-Burguillo, Sandra Rodríguez-Salvador, Sara Avila, Sara Corral Gayubas, Sergio Nuñez Sánchez, Sofía Torres Weber, Susana Encabo Lopez, Teresa Torices Rasines, Valentí Sallas, Verónica Curto-Vicente, Verónica Gómez Hijosa, Verónica Daimiel-Pedrote, Verónica Gozalo, Vicente Barrios López, Virginia Ivette Castillo Montoya, Yuri Espinoza Pérez, María CristinaBerriochoa Martínez de Pisón, David Muñoz Castillo, Carlos Donato, Isabel García García

Publikováno v: EClinicalMedicine, Vol 57, Iss , Pp 101898- (2023)

Summary: Background: Anti-COVID-19 hyperimmune immunoglobulin (hIG) can provide standardized and controlled antibody content. Data from controlled clinical trials using hIG for the prevention or treatment of COVID-19 outpatients have not been reporte

Externí odkaz: https://doaj.org/article/f1285e4c1aec4005a0de1e806cb0ea03

Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review

Autor: Nuria P Torres-Aguila, Caty Carrera, Elena Muiño, Natalia Cullell, Jara Cárcel-Márquez, Cristina Gallego-Fabrega, Jonathan González-Sánchez, Alejandro Bustamante, Pilar Delgado, Laura Ibañez, Laura Heitsch, Jerzy Krupinski, Joan Montaner, Joan Martí-Fàbregas, Carlos Cruchaga, Jin-Moo Lee, Israel Fernandez-Cadenas

Publikováno v: Journal of Stroke, Vol 21, Iss 3, Pp 276-289 (2019)

Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. In this review,

Externí odkaz: https://doaj.org/article/abcde46cee5342b881dc0c3ba4264269

Automated quantification of cerebral edema following hemispheric infarction: Application of a machine-learning algorithm to evaluate CSF shifts on serial head CTs

Autor: Yasheng Chen, Rajat Dhar, Laura Heitsch, Andria Ford, Israel Fernandez-Cadenas, Caty Carrera, Joan Montaner, Weili Lin, Dinggang Shen, Hongyu An, Jin-Moo Lee

Publikováno v: NeuroImage: Clinical, Vol 12, Iss C, Pp 673-680 (2016)

Although cerebral edema is a major cause of death and deterioration following hemispheric stroke, there remains no validated biomarker that captures the full spectrum of this critical complication. We recently demonstrated that reduction in intracran

Externí odkaz: https://doaj.org/article/390c1caba3bc47bfa6ecdd2f1e27dc77

Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Autor: Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Constance Turman, Marine Germain, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Peter Kraft, John‐Bjarne Hansen, John A Heit, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Sara L Pulit, Kristiina Rannikmäe, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Natalia S Rost, Peter M Rothwell, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil‐Smoller, James G Wilson, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu‐Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean‐François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez‐Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

Publikováno v: Temprano-Sagrera, G, Sitlani, C M, Bone, W P, Martin-Bornez, M, Voight, B F, Morrison, A C, Damrauer, S M, de Vries, P S, Smith, N L, Sabater-Lleal, M, Dehghan, A, Heath, A S, Morrison, A C, Reiner, A P, Johnson, A, Richmond, A, Peters, A, van Hylckama Vlieg, A, McKnight, B, Psaty, B M, Hayward, C, Ward-Caviness, C, O’Donnell, C, Chasman, D I, Strachan, D P, Trégouët, D A, Mook-Kanamori, D, Gill, D, Thibord, F, Asselbergs, F W, Leebeek, F W G, Rosendaal, F R, Davies, G, Homuth, G, Temprano, G, Campbell, H, Taylor, H A, Bressler, J, Huffman, J E, Rotter, J I, Yao, J, Wilson, J F, Bis, J C, Hahn, J M, Desch, K C, Wiggins, K L, Raffield, L M, Bielak, L F, Yanek, L R, Kleber, M E, Sabater-Lleal, M, Mueller, M, Kavousi, M, Mangino, M, Liu, M, Brown, M R, Conomos, M P, Jhun, M A, Chen, M H, de Maat, M P M, Pankratz, N, Smith, N L, Peyser, P A, Elliot, P, de Vries, P S, Wei, P, Wild, P S, Morange, P E, van der Harst, P, Yang, Q, Le, N Q, Marioni, R, Li, R, Damrauer, S M, Cox, S R, Trompet, S, Felix, S B, Völker, U, Tang, W, Koenig, W, Jukema, J W, Guo, X, Lindstrom, S, Wang, L, Smith, E N, Gordon, W, van Hylckama Vlieg, A, de Andrade, M, Brody, J A, Pattee, J W, Haessler, J, Brumpton, B M, Chasman, D I, Suchon, P, Chen, M H, Turman, C, Germain, M, Wiggins, K L, MacDonald, J, Braekkan, S K, Armasu, S M, Pankratz, N, Jackson, R D, Nielsen, J B, Giulianini, F, Puurunen, M K, Ibrahim, M, Heckbert, S R, Bammler, T K, Frazer, K A, McCauley, B M, Taylor, K D, Pankow, J S, Reiner, A P, Gabrielsen, M E, Deleuze, J F, O’Donnell, C J, Kim, J, McKnight, B, Kraft, P, Hansen, J B, Rosendaal, F R, Heit, J A, Psaty, B M, Tang, W, Kooperberg, C, Hveem, K, Ridker, P M, Morange, P E, Johnson, A, Kabrhel, C, Trégouët, D A, Smith, N L, Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, A K, van der Laan, S W, Gretarsdottir, S, Anderson, C D, Chong, M, Adams, H H H, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, T M, Benavente, O R, Bevan, S, Boncoraglio, G B, Brown, R D, Butterworth, A S, Carrera, C, Carty, C L, Chasman, D I, Chen, W M, Cole, J W, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, de Bakker, P I W, DeStefano, A L, den Hoed, M, Duan, Q, Engelter, S T, Falcone, G J, Gottesman, R F, Grewal, R P, Gudnason, V, Gustafsson, S, Haessler, J, Harris, T B, Hassan, A, Havulinna, A S, Heckbert, S R, Holliday, E G, Howard, G, Hsu, F C, Hyacinth, H I, Arfan Ikram, M, Ingelsson, E, Irvin, M R, Jian, X, Jiménez-Conde, J, Johnson, J A, Jukema, J W, Kanai, M, Keene, K L, Kissela, B M, Kleindorfer, D O, Kooperberg, C, Kubo, M, Lange, L A, Langefeld, C D, Langenberg, C, Launer, L J, Lee, J M, Lemmens, R, Leys, D, Lewis, C M, Lin, W Y, Lindgren, A G, Lorentzen, E, Magnusson, P K, Maguire, J, Manichaikul, A, McArdle, P F, Meschia, J F, Mitchell, B D, Mosley, T H, Nalls, M A, Ninomiya, T, O’Donnell, M J, Psaty, B M, Pulit, S L, Rannikmäe, K, Reiner, A P, Rexrode, K M, Rice, K, Rich, S S, Ridker, P M, Rost, N S, Rothwell, P M, Rotter, J I, Rundek, T, Sacco, R L, Sakaue, S, Sale, M M, Salomaa, V, Sapkota, B R, Schmidt, R, Schmidt, C O, Schminke, U, Sharma, P, Slowik, A, Sudlow, C L M, Tanislav, C, Tatlisumak, T, Taylor, K D, Thijs, V N S, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, van Duijn, C M, Walters, M, Wareham, N J, Wassertheil-Smoller, S, Wilson, J F, Wiggins, K L, Yang, Q, Yusuf, S, Amin, N, Aparicio, H S, Arnett, D K, Attia, J, Beiser, A S, Berr, C, Buring, J E, Bustamante, M, Caso, V, Cheng, Y C, Hoan Choi, S, Chowhan, A, Cullell, N, Dartigues, J F, Delavaran, H, Delgado, P, Dörr, M, Engström, G, Ford, I, Gurpreet, W S, Hamsten, A, Heitsch, L, Hozawa, A, Ibanez, L, Ilinca, A, Ingelsson, M, Iwasaki, M, Jackson, R D, Jood, K, Jousilahti, P, Kaffashian, S, Kalra, L, Kamouchi, M, Kitazono, T, Kjartansson, O, Kloss, M, Koudstaal, P J, Krupinski, J, Labovitz, D L, Laurie, C C, Levi, C R, Li, L, Lind, L, Lindgren, C M, Lioutas, V, Mei Liu, Y, Lopez, O L, Makoto, H, Martinez-Majander, N, Matsuda, K, Minegishi, N, Montaner, J, Morris, A P, Muiño, E, Müller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, E A, Reddy Peddareddygari, L, Pedersen, N L, Pera, J, Perola, M, Pezzini, A, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribasés, M, Romero, J R, Roquer, J, Rudd, A G, Sarin, A P, Sarju, R, Sarnowski, C, Sasaki, M, Satizabal, C L, Satoh, M, Sattar, N, Sawada, N, Sibolt, G, Sigurdsson, Á, Smith, A, Sobue, K, Soriano-Tárraga, C, Stanne, T, Colin Stine, O, Stott, D J, Strauch, K, Takai, T, Tanaka, H, Tanno, K, Teumer, A, Tomppo, L, Torres-Aguila, N P, Touze, E, Tsugane, S, Uitterlinden, A G, Valdimarsson, E M, van der Lee, S J, Völzke, H, Wakai, K, Weir, D, Williams, S R, Wolfe, C D A, Wong, Q, Xu, H, Yamaji, T, Sanghera, D K, Melander, O, Jern, C, Strbian, D, Fernandez-Cadenas, I, Longstreth, W T, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, J C, Saleheen, D, Stefansson, K, Worrall, B B, Kittner, S J, Seshadri, S, Fornage, M, Markus, H S, Howson, J M M, Kamatani, Y, Debette, S & Dichgans, M 2022, ' Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations ', Journal of Thrombosis and Haemostasis, vol. 20, no. 6, pp. 1331-1349 . https://doi.org/10.1111/jth.15698
Temprano-Sagrera, G, Sitlani, C M, Bone, W P, Martin-Bornez, M, Voight, B F, Morrison, A C, Damrauer, S M, de Vries, P S, Smith, N L, Sabater-Lleal, M, Dehghan, A, Heath, A S, Morrison, A C, Reiner, A P, Johnson, A, Richmond, A, Peters, A, van Hylckama Vlieg, A, McKnight, B, Psaty, B M, Hayward, C, Ward-Caviness, C, O’Donnell, C, Chasman, D, Strachan, D P, Tregouet, D A, Mook-Kanamori, D, Gill, D, Thibord, F, Asselbergs, F W, Leebeek, F W G, Rosendaal, F R, Davies, G, Homuth, G, Temprano, G, Campbell, H, Taylor, H A, Bressler, J, Huffman, J E, Rotter, J I, Yao, J, Wilson, J F, Bis, J C, Hahn, J M, Desch, K C, Wiggins, K L, Raffield, L M, Bielak, L F, Yanek, L R, Kleber, M E, Sabater-Lleal, M, Mueller, M, Kavousi, M, Mangino, M, Liu, M, Brown, M R, Conomos, M P, Jhun, M-A, Chen, M-H, de Maat, M P M, Pankratz, N, Smith, N L, Peyser, P A, Elliot, P, de Vries, P S, Wei, P, Wild, P S, Morange, P E, van der Harst, P, Yang, Q, le, N-Q, Marioni, R, Li, R, Damrauer, S M, Cox, S R, Trompet, S, Felix, S B, Völker, U, Tang, W, Koenig, W, Jukema, J W, Guo, X, Lindstrom, S, Wang, L, Smith, E N, Gordon, W, van Hylckama Vlieg, A, de Andrade, M, Brody, J A, Pattee, J W, Haessler, J, Brumpton, B M, Chasman, D I, Suchon, P, Chen, M-H, Turman, C, Germain, M, Wiggins, K L, MacDonald, J, Braekkan, S K, Armasu, S M, Pankratz, N, Jackson, R D, Nielsen, J B, Giulianini, F, Puurunen, M K, Ibrahim, M, Heckbert, S R, Bammler, T K, Frazer, K A, McCauley, B M, Taylor, K, Pankow, J S, Reiner, A P, Gabrielsen, M E, Deleuze, J-F, O’Donnell, C J, Kim, J, McKnight, B, Kraft, P, Hansen, J-B, Rosendaal, F R, Heit, J A, Psaty, B M, Tang, W, Kooperberg, C, Hveem, K, Ridker, P M, Morange, P-E, Johnson, A D, Kabrhel, C, Trégouët, D-A, Smith, N L, Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, A-K, van der Laan, S W, Gretarsdottir, S, Anderson, C D, Chong, M, Adams, H H H, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, T M, Benavente, O R, Bevan, S, Boncoraglio, G B, Brown, R D, Butterworth, A S, Carrera, C, Carty, C L, Chasman, D I, Chen, W-M, Cole, J W, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, de Bakker, P I W, DeStefano, A L, den Hoed, M, Duan, Q, Engelter, S T, Falcone, G J, Gottesman, R F, Grewal, R P, Gudnason, V, Gustafsson, S, Haessler, J, Harris, T B, Hassan, A, Havulinna, A S, Heckbert, S R, Holliday, E G, Howard, G, Hsu, F-C, Hyacinth, H I, Arfan Ikram, M, Ingelsson, E, Irvin, M R, Jian, X, Jiménez-Conde, J, Johnson, J A, Jukema, J W, Kanai, M, Keene, K L, Kissela, B M, Kleindorfer, D O, Kooperberg, C, Kubo, M, Lange, L A, Langefeld, C D, Langenberg, C, Launer, L J, Lee, J-M, Lemmens, R, Leys, D, Lewis, C M, Lin, W-Y, Lindgren, A G, Lorentzen, E, Magnusson, P K, Maguire, J, Manichaikul, A, McArdle, P F, Meschia, J F, Mitchell, B D, Mosley, T H, Nalls, M A, Ninomiya, T, O’Donnell, M J, Psaty, B M, Pulit, S L, Rannikmäe, K, Reiner, A P, Rexrode, K M, Rice, K, Rich, S S, Ridker, P M, Rost, N S, Rothwell, P M, Rotter, J I, Rundek, T, Sacco, R L, Sakaue, S, Sale, M M, Salomaa, V, Sapkota, B R, Schmidt, R, Schmidt, C O, Schminke, U, Sharma, P, Slowik, A, Sudlow, C L M, Tanislav, C, Tatlisumak, T, Taylor, K D, Thijs, V N S, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, van Duijn, C M, Walters, M, Wareham, N J, Wassertheil-Smoller, S, Wilson, J G, Wiggins, K L, Yang, Q, Yusuf, S, Amin, N, Aparicio, H S, Arnett, D K, Attia, J, Beiser, A S, Berr, C, Buring, J E, Bustamante, M, Caso, V, Cheng, Y-C, Hoan Choi, S, Chowhan, A, Cullell, N, Dartigues, J-F, Delavaran, H, Delgado, P, Dörr, M, Engström, G, Ford, I, Gurpreet, W S, Hamsten, A, Heitsch, L, Hozawa, A, Ibanez, L, Ilinca, A, Ingelsson, M, Iwasaki, M, Jackson, R D, Jood, K, Jousilahti, P, Kaffashian, S, Kalra, L, Kamouchi, M, Kitazono, T, Kjartansson, O, Kloss, M, Koudstaal, P J, Krupinski, J, Labovitz, D L, Laurie, C C, Levi, C R, Li, L, Lind, L, Lindgren, C M, Lioutas, V, Mei Liu, Y, Lopez, O L, Makoto, H, Martinez-Majander, N, Matsuda, K, Minegishi, N, Montaner, J, Morris, A P, Muiño, E, Müller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, E A, Reddy Peddareddygari, L, Pedersen, N L, Pera, J, Perola, M, Pezzini, A, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribasés, M, Romero, J R, Roquer, J, Rudd, A G, Sarin, A-P, Sarju, R, Sarnowski, C, Sasaki, M, Satizabal, C L, Satoh, M, Sattar, N, Sawada, N, Sibolt, G, Sigurdsson, Á, Smith, A, Sobue, K, Soriano-Tárraga, C, Stanne, T, Colin Stine, O, Stott, D J, Strauch, K, Takai, T, Tanaka, H, Tanno, K, Teumer, A, Tomppo, L, Torres-Aguila, N P, Touze, E, Tsugane, S, Uitterlinden, A G, Valdimarsson, E M, van der Lee, S J, Völzke, H, Wakai, K, Weir, D, Williams, S R, Wolfe, C D A, Wong, Q, Xu, H, Yamaji, T, Sanghera, D K, Melander, O, Jern, C, Strbian, D, Fernandez-Cadenas, I, Longstreth, W T, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, J C, Saleheen, D, Stefansson, K, Worrall, B B, Kittner, S J, Seshadri, S, Fornage, M, Markus, H S, Howson, J M M, Kamatani, Y, Debette, S & Dichgans, M 2022, ' Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations ', Journal of Thrombosis and Haemostasis, vol. 20, no. 6, pp. 1331-1349 . https://doi.org/10.1111/jth.15698
Journal of Thrombosis and Haemostasis, 20(6), 1331-1349. Wiley-Blackwell

Background: Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b7442423f44fe602d89a89feee11d1
https://hdl.handle.net/20.500.11820/264ae571-0038-4372-9a30-c81b5c9f6905

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Autor: Pilar Delgado, Shuo Li, Matthew Paradise, Qiong Yang, Ami Tsuchida, Uwe Völker, Maria J. Knol, Wanting Zhao, Wei Wen, Marie-Gabrielle Duperron, David-Alexandre Trégouët, Mark E. Bastin, Hans J. Grabe, Aniket Mishra, Jean Shin, Stefan Frenzel, Alexa S. Beiser, Jiyang Jiang, Mathieu Bourgey, Henry Brodaty, Jayandra J. Himali, Hieab H.H. Adams, Ralph L. Sacco, Murali Sargurupremraj, Nicole Dueker, Margaret J. Wright, Quentin Le Grand, Christopher Chen, Tomáš Paus, Katharina Wittfeld, Stéphanie Debette, Tavia E. Evans, Constance Bordes, Nicola J. Armstrong, Parva Pedram, M. Arfan Ikram, Gennady V. Roshchupkin, Pascale Marquis, Tatjana Rundek, Anbupalam Thalamuthu, Helena Schmidt, Sudha Seshadri, Takahiro Konuma, Anne Joutel, Joanna M. Wardlaw, Michelle Luciano, Israel Fernandez-Cadenas, Robin Bülow, Jose R. Romero, Maria del C. Valdés Hernández, Meike W. Vernooij, Melissa Macalli, Claudia L. Satizabal, Caty Carrera, Ching-Yu Cheng, Piyush G. Gampawar, Ycheng Zhu, Karen A. Mather, Alexander Teumer, Ian J. Deary, Guillaume Bourque, Saima Hilal, Rick M. Tankard, Reinhold E. Schmidt, Yukinori Okada, Yasaman Saba, Sabrina Schilling, Julian N. Trollor, Tien Yin Wong, Perminder S. Sachdev, Mark Lathrop, Omar (Tbc) Soukarieh, Junyi Zhang, Zoe Morris, Edith Hofer, Christophe Tzourio, Florian Dubost, Bernard Mazoyer, Susanna Muñoz Maniega

Publikováno v: Research Square

Perivascular space burden (PVS) is an emerging and possibly the earliest magnetic resonance imaging (MRI)-marker of cerebral small vessel disease (cSVD), a leading cause of stroke and dementia. Its molecular underpinnings are unknown. Genome-wide and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3675d20388bd3ea3d00a4c97f7eee4
https://doi.org/10.21203/rs.3.rs-963149/v1