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Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone.

Autor: Catto F; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.; IMAI MedTech, Wagistrasse 18, 8952 Schlieren, Zurich, Switzerland., Dadgar-Kiani E; Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 260, 8057 Zürich.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland., Kirschenbaum D; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland., Economides A; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland., Reuss AM; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland., Trevisan C; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland., Caredio D; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland., Mirzet D; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland., Frick L; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland., Weber-Stadlbauer U; Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 260, 8057 Zürich.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland., Litvinov S; Computational Science and Engineering Laboratory, ETH Zürich, Clausiusstrasse 33, 8092, Zurich, Switzerland.; Computational Science and Engineering Laboratory, Harvard University, Cambridge, MA 02138, United States., Koumoutsakos P; Computational Science and Engineering Laboratory, Harvard University, Cambridge, MA 02138, United States., Hyung Lee J; Department of Neurology and Neurological Sciences, Stanford University, CA 94305, USA.; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.; Department of Electrical Engineering, Stanford University, CA 94305, USA.; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Aguzzi A; Institute of Neuropathology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 17. Date of Electronic Publication: 2024 Aug 17.