Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Catriona T. Prendergast"'
Autor:
Catriona T. Prendergast, Robert A. Benson, Hannah E. Scales, Caio Santos Bonilha, John J. Cole, Iain McInnes, James M. Brewer, Paul Garside
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Mechanisms governing entry and exit of immune cells into and out of inflamed joints remain poorly understood. We sought herein to identify the key molecular pathways regulating such migration. Using murine models of inflammation in conjunction with m
Externí odkaz:
https://doaj.org/article/5d1175430835444c926fbbd904727585
Autor:
Daniel Paape, Catriona T. Prendergast, Helen P. Price, Johannes S. P. Doehl, Deborah F. Smith
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-16 (2020)
Abstract Background Proving that specific genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identification of suitable targets for drug development. This is especially evident i
Externí odkaz:
https://doaj.org/article/463f0595daaf427186f4594b3dbf6a5a
Autor:
Shaima Al Khabouri, Robert A. Benson, Catriona T. Prendergast, Joshua I. Gray, Thomas D. Otto, James M. Brewer, Paul Garside
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Effective tolerogenic intervention in Rheumatoid Arthritis (RA) will rely upon understanding the evolution of articular antigen specific CD4 T cell responses. TCR clonality of endogenous CD4 T cell infiltrates in early inflammatory arthritis was asse
Externí odkaz:
https://doaj.org/article/f24f091353d845b49a310b48bae536ce
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004911 (2016)
In a murine model of repeated exposure of the skin to infective Schistosoma mansoni cercariae, events leading to the priming of CD4 cells in the skin draining lymph nodes were examined. The dermal exudate cell (DEC) population recovered from repeated
Externí odkaz:
https://doaj.org/article/3d59119ecf844210b0c3cd3de0d02111
Autor:
Helen P. Price, Catriona T. Prendergast, Daniel Paape, Deborah F. Smith, Johannes S. P. Doehl
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-16 (2020)
Parasites & Vectors
Parasites & Vectors
BackgroundProving that specific genes are essential for the intracellular viability ofLeishmaniaparasites within macrophages remains a challenge for the identification of suitable targets for drug development. This is especially evident in the absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a574fb8b2c47c0461188758a4e6ddf
http://link.springer.com/article/10.1186/s13071-020-3999-1
http://link.springer.com/article/10.1186/s13071-020-3999-1
Autor:
James M. Brewer, Joshua I. Gray, Robert A. Benson, Paul Garside, Catriona T. Prendergast, Thomas D. Otto, Shaima Al Khabouri
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
ObjectivesDevelopment of effective tolerogenic therapies for Rheumatoid Arthritis (RA) relies on understanding the evolution of articular antigen specific CD4 T cell responses. TCR clonality of the endogenous CD4 T cell infiltrate in early inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a42528f6e4c9f260c73385a71b820f
https://www.frontiersin.org/articles/10.3389/fimmu.2021.669856/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.669856/full
Publikováno v:
Parasite Immunology
In areas endemic for schistosomiasis, people can often be in contact with contaminated water resulting in repeated exposures to infective Schistosoma mansoni cercariae. Using a murine model, repeated infections result in IL-10-dependent CD4(+) T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4925479511fce4dd7c6b924a7b9a03be
https://doi.org/10.1111/pim.12300
https://doi.org/10.1111/pim.12300
Publikováno v:
The Journal of Immunology Author Choice
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections, macrophages are an important source of IL-10; however, the molecular mechanism underpinning production of IL-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5f74c252786db8f068b56e25147fd7
https://doi.org/10.4049/jimmunol.1500146
https://doi.org/10.4049/jimmunol.1500146
Autor:
James M. Brewer, Robert A. Benson, Catriona T. Prendergast, Iain B. McInnes, Shaima Al-Khabouri, Agapitos Patakas, Paul Garside, Claire L. McIntyre
Publikováno v:
Annals of the rheumatic diseases. 77(4)
ObjectivesSuccessful early intervention in rheumatoid arthritis (RA) with the aim of resetting immunological tolerance requires a clearer understanding of how specificity, cellular kinetics and spatial behaviour shape the evolution of articular T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72e7b439a6726ba8eef40583cdc8d06
https://pubmed.ncbi.nlm.nih.gov/29358281
https://pubmed.ncbi.nlm.nih.gov/29358281
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 9:315-327
Under normal physiological conditions there is minimal entry of immune cells into the central nervous system (CNS) for the purpose of immune surveillance. During inflammation, however, extensive infiltration of immune cells can lead to the induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1770b7d10afc3fd971e7138fd2cad516
https://doi.org/10.2174/187153009789839219
https://doi.org/10.2174/187153009789839219