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pro vyhledávání: '"Catriona M.H. Anderson"'
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Members of the SLC36 family of proton-coupled amino acid transporters are involved in membrane transport of amino acids and derivatives [29, 30]. The four transporters show variable tissue expression patterns and are expressed in various cell types a
Autor:
Sara Adobati, Catriona M.H. Anderson, David T. Thwaites, Chiara Paravicini, Uliano Guerrini, Luca Palazzolo, T. Laurenzi, Ivano Eberini, Cesare Indiveri, S. Saporiti, Elisabetta Gianazza
Publikováno v:
SLAS Discovery. 24:928-938
SLC6A14 (ATB0,+) is a sodium- and chloride-dependent neutral and dibasic amino acid transporter that regulates the distribution of amino acids across cell membranes. The transporter is overexpresse...
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Members of the SLC36 family of proton-coupled amino acid transporters are involved in membrane transport of amino acids and derivatives. The four transporters show variable tissue expression patterns and are expressed in various cell types at the pla
Autor:
Andrew K Watson, Catriona M.H. Anderson, David T. Thwaites, Rebecca J. Hall, Nichola J. Conlon, T. Martin Embley, Timothy R. Cheek, Noel Edwards
Publikováno v:
Cellular and Molecular Life Sciences
Amino acid transporters are essential components of prokaryote and eukaryote cells, possess distinct physiological functions, and differ markedly in substrate specificity. Amino acid transporters can be both drug targets and drug transporters (bioava
Publikováno v:
British Journal of Pharmacology. 164:1802-1816
Members of the solute carrier (SLC) 36 family are involved in transmembrane movement of amino acids and derivatives. SLC36 consists of four members. SLC36A1 and SLC36A2 both function as H+-coupled amino acid symporters. SLC36A1 is expressed at the lu
Autor:
David T. Thwaites, Kelly M Gatfield, Noel Edwards, Catriona M.H. Anderson, Vadivel Ganapathy, Mark Jevons
Publikováno v:
Biochimica et Biophysica Acta
The H+-coupled amino acid transporter PAT2 (SLC36A2) transports the amino acids proline, glycine, alanine and hydroxyproline. A physiological role played by PAT2 in amino acid reabsorption in the renal proximal tubule is demonstrated by mutations in
Autor:
Alison Howard, Vadivel Ganapathy, Julian R.F. Walters, Catriona M.H. Anderson, David T. Thwaites
Publikováno v:
The Journal of Physiology. 587:731-744
Taurine is an essential amino acid in some mammals and is conditionally essential in humans. Taurine is an abundant component of meat and fish-based foods and has been used as an oral supplement in the treatment of disorders such as cystic fibrosis a
Publikováno v:
The Journal of Physiology. 586:4061-4067
The β-alanine carrier was characterized functionally in the 1960s to 1980s at the luminal surface of the ileal mucosal wall and is a Na+- and Cl−-dependent transporter of a number of essential and non-essential cationic and dipolar amino acids inc
Publikováno v:
Experimental Physiology. 92:603-619
The H(+)-electrochemical gradient was originally considered as a driving force for solute transport only across cellular membranes of bacteria, plants and yeast. However, in the mammalian small intestine, a H(+)-electrochemical gradient is present at