Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss.

Autor: Catriona Paul, Joanne E Povey, Nicola J Lawrence, Jim Selfridge, David W Melton, Philippa T K Saunders

Publikováno v: PLoS ONE, Vol 2, Iss 10, p e989 (2007)

BACKGROUND:Infertility affects approximately 20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating in the male germ line on infertility is poorly understood but may increase miscarr

Externí odkaz: https://doaj.org/article/14b57c3ec4c547e9b833ede6e287e1db

A Single, Mild, Transient Scrotal Heat Stress Causes Hypoxia and Oxidative Stress in Mouse Testes, Which Induces Germ Cell Death1

Autor: Philippa T. K. Saunders, Catriona Paul, Serena Teng

Publikováno v: Biology of Reproduction. 80:913-919

Spermatogenesis is a temperature-dependent process, and increases in scrotal temperature can disrupt its progression. We previously showed that heat stress causes DNA damage in germ cells, an increase in germ cell death (as seen on TUNEL staining), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74876136f70a28a4078561783abaa4ab
https://doi.org/10.1095/biolreprod.108.071779

Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility?

Autor: Catriona Paul, David W. Melton, Philippa T. K. Saunders

Publikováno v: Paul, C, Melton, D W & Saunders, P T K 2008, ' Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility? ', Molecular Human Reproduction, vol. 14, no. 1, pp. 1-8 . https://doi.org/10.1093/molehr/gam089

In Europe up to one in four couples experience difficulty conceiving and in half of these cases the problem has been attributed to sub or infertility in the male partner. The development of assisted reproductive technologies (ART) such as in vitro fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df41d55d5d3623d44b729a4d53eb9566
https://doi.org/10.1093/molehr/gam089

Cellular and Hormonal Disruption of Fetal Testis Development in Sheep Reared on Pasture Treated with Sewage Sludge

Autor: Catriona Paul, Hayley M. Scott, Stewart M. Rhind, Carol Kyle, Richard M. Sharpe, Chris McKinnell

Publikováno v: Environmental Health Perspectives
Paul, C, Rhind, S M, Kyle, C E, Scott, H, McKinnell, C & Sharpe, R M 2005, ' Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge ', Environmental Health Perspectives, vol. 113, no. 11, pp. 1580-7 .

The purpose of this study was to evaluate whether experimental exposure of pregnant sheep to a mixture of environmental chemicals added to pasture as sewage sludge (n = 9 treated animals) exerted effects on fetal testis development or function; appli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ccfd930b55ed03159e5a467bed5f37
http://europepmc.org/articles/PMC1310922

Aging results in molecular changes in an enriched population of undifferentiated rat spermatogonia

Autor: Catriona, Paul, Makoto, Nagano, Bernard, Robaire

Publikováno v: Biology of reproduction. 89(6)

A strong correlation exists between increasing paternal age and a decline in reproductive function. Testis aging is associated with testicular atrophy, increased DNA damage, and de novo mutations. It is unclear whether these problems arise from the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd2c0aea0c396ddd36771ba508825512
https://pubmed.ncbi.nlm.nih.gov/24227752