Immune Toxicity with Checkpoint Inhibition for Metastatic Melanoma: Case Series and Clinical Management

Autor: Anna J. Lomax, Jennifer Lim, Robert Cheng, Arianne Sweeting, Patricia Lowe, Neil McGill, Nicholas Shackel, Elizabeth L. Chua, Catriona McNeil

Publikováno v: Journal of Skin Cancer, Vol 2018 (2018)

Immune checkpoint inhibitors (anti-PD-1 and anti-CTLA-4 antibodies) are a standard of care for advanced melanoma. Novel toxicities comprise immune-related adverse events (irAE). With increasing use, irAE require recognition, practical management stra

Externí odkaz: https://doaj.org/article/6a6c7629b3c04ae4a1a5ce60b738c779

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Autor: Bruno Sgromo, Leanne Hodson, Richard S. Gillies, Jeremy W. Tomlinson, Catriona McNeil, John Ryan, de Bunt Martijn van, Wiebke Arlt, Charlotte J. Green, Laura Gathercole, Lea Marchand, Anastasia Arvaniti, Sara Althari, Niall Dempster, Nikolaos Nikolaou, Beverly A. Hughes

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fd3627d8aa84de38d6f6a23af6d1051
https://doi.org/10.1530/endoabs.67.o30

Cediranib in patients with alveolar soft-part sarcoma (CASPS): a double-blind, placebo-controlled, randomised, phase 2 trial

Autor: Ian, Judson, James P, Morden, Lucy, Kilburn, Michael, Leahy, Charlotte, Benson, Vivek, Bhadri, Quentin, Campbell-Hewson, Ricardo, Cubedo, Adam, Dangoor, Lisa, Fox, Ivo, Hennig, Katy, Jarman, Warren, Joubert, Sarah, Kernaghan, Antonio, López Pousa, Catriona, McNeil, Beatrice, Seddon, Claire, Snowdon, Martin, Tattersall, Christy, Toms, Javier, Martinez Trufero, Judith M, Bliss

Publikováno v: LANCET ONCOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Judson, I, Morden, J P, Kilburn, L, Leahy, M, Benson, C, Bhadri, V, Campbell-Hewson, Q, Cubedo, R, Dangoor, A, Fox, L, Hennig, I, Jarman, K, Joubert, W, Kernaghan, S, López Pousa, A, McNeil, C, Seddon, B, Snowdon, C, Tattersall, M, Toms, C, Martinez Trufero, J & Bliss, J M 2019, ' Cediranib in patients with alveolar soft-part sarcoma (CASPS) : a double-blind, placebo-controlled, randomised, phase 2 trial ', The Lancet Oncology, vol. 20, no. 7, pp. 1023-1034 . https://doi.org/10.1016/S1470-2045(19)30215-3

Background: Alveolar soft-part sarcoma (ASPS) is a rare soft-tissue sarcoma that is unresponsive to chemotherapy. Cediranib, a tyrosine-kinase inhibitor, has shown substantial activity in ASPS in non-randomised studies. The Cediranib in Alveolar Soft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b0929c79dffe77584448e7ebd0d0ea13
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13793

5[beta]-reductase (AKR1D1) is a potent regulator of hepatic insulin sensitivity, carbohydrate and lipid metabolism in vitro and in vivo

Autor: Nikolaos Nikolaou, Laura Gathercole, Lea Marchand, Sara Althari, Charlotte Green, Catriona McNeil, Shelley Harris, de Bunt Martijn van, Wiebke Arlt, Leanne Hodson, Jeremy Tomlinson

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::815bcfef64351147febfe119d0433034
https://doi.org/10.1530/endoabs.56.oc6.1

SAT-353-The effect of metformin on hepatic fatty acid partitioning; an investigation using human in vivo and in vitro models

Autor: Charlotte J. Green, Catriona McNeil, Jane E. Francis, Leanne Hodson, Thomas Marjot, Jeremy W. Tomlinson, Stefan Neubauer, Ahmad Moolla, Jonathan Hazlehurst

Publikováno v: Journal of Hepatology. 70:e794-e795

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64e7e2588b724a437ff7928397b18f26
https://doi.org/10.1016/s0618-8278(19)31583-x