Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Catrine Sioberg"'
Autor:
Stephen T. Durant, L. David Finger, Mark J. Thompson, Jane A. Grasby, Thomas Ward, J. Willem M. Nissink, W. Mark Abbott, Steven J. Shaw, Catrine Sioberg, Clifford David Jones, Judit E. Debreczeni, Jack C. Exell, Claire McWhirter, Daniel Martinez Molina
Publikováno v:
Nature chemical biology
The structure-specific nuclease human flap endonuclease-1 (hFEN1) plays a key role in DNA replication and repair and may be of interest as an oncology target. We present the crystal structure of inhibitor-bound hFEN1, which shows a cyclic N-hydroxyur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acad248f883063128e76237c1086c207
http://europepmc.org/articles/PMC5348030
http://europepmc.org/articles/PMC5348030
Publikováno v:
Cancer Research. 77:4024-4024
Targeted therapies are dependent on adequate occupancy and target engagement to reach their efficacy measure. Yet, more than half of novel candidate drugs entering clinical trial stage fail before proof of concept is achieved. Inadequate target engag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b56638061187d509b54a1e9a7ac4dd8
https://doi.org/10.1158/1538-7445.am2017-4024
https://doi.org/10.1158/1538-7445.am2017-4024
Publikováno v:
Cancer Research. 76:354-354
Targeted therapies are dependent on adequate occupancy and target engagement to reach their efficacy measure. Yet, more than half of novel candidate drugs entering clinical trial stage fail before proof of concept is achieved. Inadequate target engag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::707eee026f3ce9a53be5607feb631a3d
https://doi.org/10.1158/1538-7445.am2016-354
https://doi.org/10.1158/1538-7445.am2016-354