Modeling genetic platelet disorders with human pluripotent stem cells: mega-progress but wanting more on our plate(let)

Autor: Catriana C. Nations, Paul Gadue, Giulia Pavani, Deborah L. French

Publikováno v: Curr Opin Hematol

Purpose of review Megakaryocytes are rare hematopoietic cells that play an instrumental role in hemostasis, and other important biological processes such as immunity and wound healing. With the advent of cell reprogramming technologies and advances i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b68c0743c226675aad526418122c3e5
https://doi.org/10.1097/moh.0000000000000671

Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis.

Autor: Wilken MB; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Fonar G; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Qiu R; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Bennett L; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tober J; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nations C; Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Pavani G; Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Tsao V; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Garifallou J; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Petit C; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Maguire JA; Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Gagne A; Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Okoli N; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Gadue P; Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Chou ST; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., French DL; Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Speck NA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Thom CS; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: thomc@chop.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2024 Sep 10; Vol. 19 (9), pp. 1264-1276. Date of Electronic Publication: 2024 Aug 29.