Výsledky vyhledávání - "Cation chloride co-transporter"

Targeting the Cation-Chloride Co-Transporter NKCC1 to Re-Establish GABAergic Inhibition and an Appropriate Excitatory/Inhibitory Balance in Selective Neuronal Circuits: A Novel Approach for the Treatment of Alzheimer’s Disease

Autor: Simona Capsoni, Ivan Arisi, Francesca Malerba, Mara D’Onofrio, Antonino Cattaneo, Enrico Cherubini

Publikováno v: Brain Sciences. 12:783

GABA, the main inhibitory neurotransmitter in the adult brain, depolarizes and excites immature neurons because of an initially higher intracellular chloride concentration [Cl−]i due to the delayed expression of the chloride exporter KCC2 at birth.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255ff208428d5b1b9af45826d1074ccb
https://doi.org/10.3390/brainsci12060783

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GABAergic transmission underlies interictal epileptogenicity in pediatric FCD

Autor: Blauwblomme, Thomas, Dossi, Elena, Pellegrino, Christophe, Goubert, Emmanuelle, Gal Iglesias, Beatriz, Sainte-Rose, Christian, Rouach, Nathalie, Nabbout, Rima, Huberfeld, Gilles

Publikováno v: Annals of Neurology
Annals of Neurology, Wiley, 2018, ⟨10.1002/ana.25403⟩
Annals of Neurology, 2018, ⟨10.1002/ana.25403⟩

International audience; Objective: Dysregulation of GABAergic transmission has been reported in lesional acquired epilepsies (gliomas, hippocampal sclerosis). We investigated its involvement in a developmental disorder, human Focal Cortical Dysplasia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d4cdeee546fa9f45988044c2e0c32c37
https://hal-amu.archives-ouvertes.fr/hal-01971710/file/10.1002@ana.25403.pdf

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SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Autor: Dario R. Alessi, Jacob Thastrup, Maria Deak, Alberto C. Vitari, Fatema H. Rafiqi, Youcef Mehellou, Eulalia Pozo-Guisado

Publikováno v: Biochemical Journal

Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress by phosphorylation of its T-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d214b7cc739690322d66483dbf9ed5c
https://doi.org/10.1042/bj20111879

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A kainate receptor subunit promotes the recycling of the neuron-specific K ⁺ -Cl ^- co-transporter KCC2 in hippocampal neurons.

Autor: Pressey JC; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Mahadevan V; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Khademullah CS; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Dargaei Z; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Chevrier J; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Ye W; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Huang M; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Chauhan AK; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Meas SJ; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and., Uvarov P; the Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland., Airaksinen MS; the Department of Anatomy, University of Helsinki, 00014 Helsinki, Finland., Woodin MA; From the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada and m.woodin@utoronto.ca.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 Apr 14; Vol. 292 (15), pp. 6190-6201. Date of Electronic Publication: 2017 Feb 24.

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