Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Cathy Slack"'
Autor:
Suhayl Mulla, Adele R. Ludlam, Aiman Elragig, Cathy Slack, Zita Balklava, Michael Stich, Alex Cheong
Publikováno v:
Royal Society Open Science, Vol 10, Iss 2 (2023)
Ageing research focuses on identifying lifespan modifiers and understanding and appropriately interpreting their effects. One of the most relevant quantities being studied is the shape of the survival curve that can reveal crucial information on the
Externí odkaz:
https://doaj.org/article/ba67b3d7508d4eb1905a6c215ea6dc08
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/aa758ea584e343299173130a00706b1e
Autor:
Holly Prudden, Roger Tatoud, Cathy Slack, Robin Shattock, Pervin Anklesaria, Linda-Gail Bekker, Susan Buchbinder
Publikováno v:
Vaccines, Vol 11, Iss 5, p 970 (2023)
The development of safe and effective HIV vaccines has been a scientific challenge for more than 40 years. Despite disappointing results from efficacy clinical trials, much has been learnt from years of research and development. In a rapidly evolving
Externí odkaz:
https://doaj.org/article/809d7483d34a4a71bae0685caae6f520
Autor:
Jorge Iván Castillo-Quan, Li Li, Kerri J. Kinghorn, Dobril K. Ivanov, Luke S. Tain, Cathy Slack, Fiona Kerr, Tobias Nespital, Janet Thornton, John Hardy, Ivana Bjedov, Linda Partridge
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 638-650 (2016)
The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that li
Externí odkaz:
https://doaj.org/article/ebe05bc7d909406f8b69e27cd265d60a
Autor:
Nazif Alic, Jennifer M. Tullet, Teresa Niccoli, Susan Broughton, Matthew P. Hoddinott, Cathy Slack, David Gems, Linda Partridge
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 608-616 (2014)
Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively. Both are required for lifespan extension by reduced insulin/Igf signal
Externí odkaz:
https://doaj.org/article/b1f7e156bb1b4687852b1e07a9da0b64
Autor:
Nazif Alic, T Daniel Andrews, Maria E Giannakou, Irene Papatheodorou, Cathy Slack, Matthew P Hoddinott, Helena M Cochemé, Eugene F Schuster, Janet M Thornton, Linda Partridge
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-17 (2011)
Abstract FoxO transcription factors, inhibited by insulin/insulin‐like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult f
Externí odkaz:
https://doaj.org/article/a19fe5b02a51451f857cd72f46fb2aa1
Autor:
Cathy Slack, Anne Strode
Publikováno v:
South African Journal of Bioethics and Law, Vol 9, Iss 1, Pp 35-35 (2016)
Research ethics committees (RECs) in South Africa may require consent from a parent or legal guardian for child research. In instances where an REC determines that parental or guardianship consent is required, how far should researchers go to establi
Externí odkaz:
https://doaj.org/article/b50a82b84cf844fcadda620b2a5e03aa
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47699 (2012)
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated protein kinase (AMPK) and the AMPK-activati
Externí odkaz:
https://doaj.org/article/ac374076293c454ba119eda1fe95c64d
Autor:
Nazif Alic, Matthew P Hoddinott, Andrea Foley, Cathy Slack, Matthew D W Piper, Linda Partridge
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45367 (2012)
RNA interference (RNAi) provides an important tool for gene function discovery. It has been widely exploited in Caenorhabditis elegans ageing research because it does not appear to have any non-specific effects on ageing-related traits in that model
Externí odkaz:
https://doaj.org/article/fbb56f75b10b4349b6ccfdadf828524f
Autor:
Cathy Slack, Christian Werz, Daniela Wieser, Nazif Alic, Andrea Foley, Hugo Stocker, Dominic J Withers, Janet M Thornton, Ernst Hafen, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 6, Iss 3, p e1000881 (2010)
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein-protein interaction domain
Externí odkaz:
https://doaj.org/article/1ab7b39a1371470e9eb6be059875069a