Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Cathy Slack"'
Autor:
Suhayl Mulla, Adele R. Ludlam, Aiman Elragig, Cathy Slack, Zita Balklava, Michael Stich, Alex Cheong
Publikováno v:
Royal Society Open Science, Vol 10, Iss 2 (2023)
Ageing research focuses on identifying lifespan modifiers and understanding and appropriately interpreting their effects. One of the most relevant quantities being studied is the shape of the survival curve that can reveal crucial information on the
Externí odkaz:
https://doaj.org/article/ba67b3d7508d4eb1905a6c215ea6dc08
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/aa758ea584e343299173130a00706b1e
Autor:
Holly Prudden, Roger Tatoud, Cathy Slack, Robin Shattock, Pervin Anklesaria, Linda-Gail Bekker, Susan Buchbinder
Publikováno v:
Vaccines, Vol 11, Iss 5, p 970 (2023)
The development of safe and effective HIV vaccines has been a scientific challenge for more than 40 years. Despite disappointing results from efficacy clinical trials, much has been learnt from years of research and development. In a rapidly evolving
Externí odkaz:
https://doaj.org/article/809d7483d34a4a71bae0685caae6f520
Autor:
Jorge Iván Castillo-Quan, Li Li, Kerri J. Kinghorn, Dobril K. Ivanov, Luke S. Tain, Cathy Slack, Fiona Kerr, Tobias Nespital, Janet Thornton, John Hardy, Ivana Bjedov, Linda Partridge
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 638-650 (2016)
The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that li
Externí odkaz:
https://doaj.org/article/ebe05bc7d909406f8b69e27cd265d60a
Autor:
Nazif Alic, Jennifer M. Tullet, Teresa Niccoli, Susan Broughton, Matthew P. Hoddinott, Cathy Slack, David Gems, Linda Partridge
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 608-616 (2014)
Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively. Both are required for lifespan extension by reduced insulin/Igf signal
Externí odkaz:
https://doaj.org/article/b1f7e156bb1b4687852b1e07a9da0b64
Autor:
Nazif Alic, T Daniel Andrews, Maria E Giannakou, Irene Papatheodorou, Cathy Slack, Matthew P Hoddinott, Helena M Cochemé, Eugene F Schuster, Janet M Thornton, Linda Partridge
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-17 (2011)
Abstract FoxO transcription factors, inhibited by insulin/insulin‐like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult f
Externí odkaz:
https://doaj.org/article/a19fe5b02a51451f857cd72f46fb2aa1
Autor:
Cathy Slack, Anne Strode
Publikováno v:
South African Journal of Bioethics and Law, Vol 9, Iss 1, Pp 35-35 (2016)
Research ethics committees (RECs) in South Africa may require consent from a parent or legal guardian for child research. In instances where an REC determines that parental or guardianship consent is required, how far should researchers go to establi
Externí odkaz:
https://doaj.org/article/b50a82b84cf844fcadda620b2a5e03aa
Autor:
Zhengqi Chen, Cathy Slack, Adel M Alqarni, Julia B. Cordero, Martin P. Zeidler, Ilaria Bellantuono
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 77(8)
Over recent decades, increased longevity has not been paralleled by extended health span, resulting in more years spent with multiple diseases in older age. As such, interventions to improve health span are urgently required. Zoledronate (Zol) is a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a86f5c000620df521630409568b392
https://pubmed.ncbi.nlm.nih.gov/34137822
https://pubmed.ncbi.nlm.nih.gov/34137822
Increased longevity has not been paralleled by extended healthspan, resulting in more years spent with multiple diseases in older age. As such, interventions to improve healthspan are urgently required. Zoledronate is a nitrogen containing bisphospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f5eae56261a33f4a9e3ff15ac0f7da
Autor:
Abigail Otchere, Daniel N. Wiseman, David R. Poyner, Romez Uddin, Cathy Slack, Alice Rothnie, Sarah J Routledge, Roslyn M. Bill, Jaimin H. Patel, Alan D. Goddard, Naomi L. Pollock
Publikováno v:
Protein Expression and Purification
Given their extensive role in cell signalling, GPCRs are significant drug targets; despite this, many of these receptors have limited or no available prophylaxis. Novel drug design and discovery significantly rely on structure determination, of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af1c1d1608f7785d087a40ab468c9c1