Výsledky vyhledávání - "Cathy S, Yam"

Akademický článek

Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.

Autor: Adeline M Hajjar, Robert K Ernst, Jaehun Yi, Cathy S Yam, Samuel I Miller

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186308 (2017)

To address the role of Toll-like receptor 4 (TLR4) single nucleotide polymorphisms (SNP) in lipopolysaccharide (LPS) recognition, we generated mice that differed only in the sequence of TLR4. We used a bacterial artificial chromosome (BAC) transgenic

Externí odkaz: https://doaj.org/article/3cb356c675384d66adcc315a0e0ab69a

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Akademický článek

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

Autor: Adeline M Hajjar, Robert K Ernst, Edgardo S Fortuno, Alicia S Brasfield, Cathy S Yam, Lindsay A Newlon, Tobias R Kollmann, Samuel I Miller, Christopher B Wilson

Publikováno v: PLoS Pathogens, Vol 8, Iss 10, p e1002963 (2012)

Although lipopolysaccharide (LPS) stimulation through the Toll-like receptor (TLR)-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remai

Externí odkaz: https://doaj.org/article/2ed58c4147da46e883f07ede1e6adae8

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Substitution of the Bordetella pertussis Lipid A Phosphate Groups with Glucosamine Is Required for Robust NF-κB Activation and Release of Proinflammatory Cytokines in Cells Expressing Human but Not Murine Toll-Like Receptor 4-MD-2-CD14

Autor: Nita R. Shah, Alexey Novikov, Martine Caroff, Rachel C. Fernandez, Nico Marr, Adeline M. Hajjar, Cathy S. Yam

Publikováno v: Infection and Immunity. 78:2060-2069

Bordetella pertussis endotoxin is a key modulator of the host immune response, mainly due to the role of its lipid A moiety in Toll-like receptor 4 (TLR4)-mediated signaling. We have previously demonstrated that the lipid A phosphate groups of B. per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97cd3a74e26cfa39ab59d927f9fec44a
https://doi.org/10.1128/iai.01346-09

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Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness

Autor: Robert K. Ernst, Jaehun Yi, Samuel I. Miller, Cathy S. Yam, Adeline M. Hajjar

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0186308 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f091ba761161e17af5c61af9947f8700
https://doi.org/10.1371/journal.pone.0186308

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Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice

Autor: Piper M. Treuting, Lisa Phuong Anh Nguyen, Lee Nagy, Jaehun Yi, Alicia Brasfield, Adeline M. Hajjar, Cathy S. Yam, Jessica M. Snyder

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107257 (2014)
PLoS ONE

A humanized TLR7/TLR8 transgenic mouse line was engineered for studies using TLR7/8 ligands as vaccine adjuvants. The mice developed a spontaneous immune-mediated phenotype prior to six months of age characterized by runting, lethargy, blepharitis, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcc46afe6cfffd0d824b1dfaa0c572d
http://europepmc.org/articles/PMC4168129?pdf=render

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Whole Spleen Flow Cytometry Assay

Autor: Cathy S. Yam, Adeline M. Hajjar

Publikováno v: BIO-PROTOCOL. 3

[Abstract] In the Whole Spleen Flow Cytometry Assay, we used splenocytes directly ex vivo for stimulation with a variety of TLR ligands. The splenocytes were stimulated for a total of 4 h, then stained for intracellular cytokines. We then examined cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04c54cb15d6e9628f5b47e513a7d6bfd
https://doi.org/10.21769/bioprotoc.834

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Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica

Autor: Christopher B. Wilson, Tobias R. Kollmann, Lindsay A. Newlon, Samuel I. Miller, Alicia Brasfield, Cathy S. Yam, Robert K. Ernst, Adeline M. Hajjar, Edgardo S. Fortuno

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 8, Iss 10, p e1002963 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a44924b5344d5fc99726ca9a8b09e6
https://pubmed.ncbi.nlm.nih.gov/23071439

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Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14

Autor: Nico, Marr, Adeline M, Hajjar, Nita R, Shah, Alexey, Novikov, Cathy S, Yam, Martine, Caroff, Rachel C, Fernandez

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2010, 78 (5), pp.2060-9. ⟨10.1128/IAI.01346-09⟩

International audience; Bordetella pertussis endotoxin is a key modulator of the host immune response, mainly due to the role of its lipid A moiety in Toll-like receptor 4 (TLR4)-mediated signaling. We have previously demonstrated that the lipid A ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4fc789ae410ee2fe40080f8a4bed9cc5
https://hal.archives-ouvertes.fr/hal-00506400

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