Multiplexed measurement of candidate blood protein biomarkers of heart failure

Autor: Claire Tonry, Ken McDonald, Mark Ledwidge, Belinda Hernandez, Nadezhda Glezeva, Cathy Rooney, Brian Morrissey, Stephen R. Pennington, John A. Baugh, Chris J. Watson

Publikováno v: ESC Heart Failure, Vol 8, Iss 3, Pp 2248-2258 (2021)

Abstract Aims There is a critical need for better biomarkers so that heart failure can be diagnosed at an earlier stage and with greater accuracy. The purpose of this study was to design a robust mass spectrometry (MS)‐based assay for the simultane

Externí odkaz: https://doaj.org/article/25f25217bca44988849d266b4594bfe3

Multiplexed measurement of candidate blood protein biomarkers of heart failure

Autor: Chris Watson, Stephen R. Pennington, Nadezhda Glezeva, Brian Morrissey, Mark Ledwidge, John A. Baugh, Belinda Hernández, Cathy Rooney, Kenneth McDonald, Claire Tonry

Publikováno v: ESC Heart Failure, Vol 8, Iss 3, Pp 2248-2258 (2021)
Tonry, C, McDonald, K, Ledwidge, M, Hernandez, B, Glezeva, N, Rooney, C, Morrissey, B, Pennington, S R, Baugh, J A & Watson, C J 2021, ' Multiplexed measurement of candidate blood protein biomarkers of heart failure ', ECS Heart Failure . https://doi.org/10.1002/ehf2.13320
ESC Heart Failure

AIMS: There is a critical need for better biomarkers so that heart failure can be diagnosed at an earlier stage and with greater accuracy. The purpose of this study was to design a robust mass spectrometry (MS)-based assay for the simultaneous measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3e5cb9c0a0c01a8fa84c9c058e0e30
https://doaj.org/article/25f25217bca44988849d266b4594bfe3

Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer

Autor: T. Brendan Murphy, Keefe Murphy, Pauline M. Rudd, Antoinette S. Perry, Anna L. Walsh, Radka Saldova, Orla Sheils, Cathy Rooney, R. William G. Watson, John J. O'Leary, Stephen P. Finn, Stephen R. Pennington, Louise Flynn, Denis C. Shields, Susie Boyce, Colm J. O'Rourke, Sarah Gilgunn, Richard O'Kennedy, Henning Stöckmann

Publikováno v: Molecular Oncology, Vol 12, Iss 9, Pp 1513-1525 (2018)
Molecular Oncology

Classifying indolent prostate cancer represents a significant clinical challenge. We investigated whether integrating data from different omic platforms could identify a biomarker panel with improved performance compared to individual platforms alone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02506239ca218eee4dc24e6ad666b928
https://doi.org/10.1002/1878-0261.12348

BS15 Multiplexed measurement of protein biomarkers of cardiovascular disease in blood

Autor: Brian Morrissey, Christopher A. Watson, Belinda Hernández, Nadezhda Glezeva, Cathy Rooney, Claire Tonry, Mark Ledwidge, Stephen R. Pennington, John A. Baugh, Kenneth McDonald

Publikováno v: Basic Science.

Brief introduction Almost half of all deaths in Europe are attributable to by Cardiovascular Disease (CVD). There is a critical unmet need for better biomarkers so that CVD can be diagnosed at an earlier stage and with greater accuracy. Mass spectrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53189ee85b7ecc2173aaee74e4541e9f
https://doi.org/10.1136/heartjnl-2019-bcs.178

Application of a discovery to targeted LC–MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration

Autor: Angela Mally, Susanne Ramm, B. Morissey, Stephen R. Pennington, Belinda Hernández, Cathy Rooney

Publikováno v: Toxicology. 331:100-111

Increasing experimental and clinical evidence suggest a contribution of non-drug related risk factors (e.g., underlying disease, bacterial/viral infection) to idiosyncratic drug reactions (IDR). Our previous work showed that co-treatment with bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7de908f9392c7387452a5caaa4e00f
https://doi.org/10.1016/j.tox.2015.03.004