Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cathy Reddick"'
Autor:
Gregory P. Adams, Tin Khor, Feng Chen, Kai Ma, Marion Scocca, Aranapakam Venkatesan, Cathy Reddick, Mary Hilgart, Thomas Gardinier, Fei Wu, Melik Turker, Peiming Chen, Vaibhav Patel, Eliel Bayever
Publikováno v:
Cancer Research. 83:837-837
Antibody-drug conjugates (ADCs) exhibit limited efficacy against brain malignancies due to their inability to cross the blood-brain barrier (BBB) and penetrate into solid tumors. In clinical imaging studies C’Dots readily crossed tumor-disrupted BB
Autor:
Gregory P. Adams, Kai Ma, Feng Chen, Marion Scocca, Aranapakam Venkatesan, Cathy Reddick, Mary Hilgart, Thomas Gardinier, Fei Wu, Melik Turker, Peiming Chen, Tin Khor, Vaibhav Patel, Eliel Bayever
Publikováno v:
Cancer Research. 82:1077-1077
While several antibody-drug conjugates (ADCs) have shown efficacy in the treatment of solid tumors ADCs remain limited in their therapeutic efficacy due to long circulatory half-life and limited tumor penetration. Ultra-small (sub-10nm) C’Dot-drug-
Autor:
Patricia S. Braly, Jyoti Chauhan, Christopher A Breed, Dennis Yi-Shin Kuo, Robert W. Holloway, Devansu Tewari, Sarah Gill, John O. Schorge, Sunil Gupta, Michael A. Gold, Susan C. Modesitt, Angeles Alvarez Secord, Cathy Reddick
Publikováno v:
Journal of Clinical Oncology. 39:TPS5606-TPS5606
TPS5606 Background: Oregovomab binds tumor-associated CA125 rendering the target antigen CA125 more immunogenic or “neoantigen-like” through altered and enhanced antigen processing and presentation to specific T cells. This phenomenon is hypothes
Autor:
A. Yovine, Yong Zhang, Neelima Denduluri, Richard Greil, Kimberly L. Blackwell, Matthew Squires, Fabrice Andre, Cathy Reddick
Publikováno v:
Journal of Clinical Oncology. 30:TPS1148-TPS1148
TPS1148 Background: Overcoming endocrine resistance is a critical goal in the treatment of hormone receptor−positive (HR+) breast cancer. Molecular mechanisms associated with endocrine resistance include adaptive “cross-talk” between the estrog
Autor:
Eugene Tan, Cathy Reddick, Ann-Lii Cheng, Michael Shi, Yong Zhang, Yongyu Wang, Ho Yeong Lim, Ronnie T.P. Poon, Sumitra Throngprasert
Publikováno v:
Journal of Clinical Oncology. 30:TPS4147-TPS4147
TPS4147 Background: Hepatocellular carcinoma (HCC) is a highly vascularized tumor that may rely on tumor angiogenesis for growth, invasion, and metastasis. Inhibition of the vascular endothelial growth factor receptor (VEGFR) and platelet-derived gro