Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cathy O. Bull"'
Autor:
Karl Ziegelbauer, Dominik Mumberg, William J. Scott, Scott M. Wilhelm, Martin Hentemann, Dean P. Wilkie, Paul R. Fracasso, Christoph A. Schatz, Andrea Haegebarth, Claudia Schneider, Cathy O. Bull, Bruce R. Rowley, Ningshu Liu
Supplementary Materials and Methods. Supplemental Table S1. Combination effects of BAY 80-6946 and lapatinib on caspase 9 activation in BT474 cells. Supplemental Table S2. Single dose i.v. pharmacokinetic parameter of BAY 80-6946 in female nude rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1474ccb7f22408bd87b65c4e0d64c418
https://doi.org/10.1158/1535-7163.22498903.v1
https://doi.org/10.1158/1535-7163.22498903.v1
Autor:
Jean-Marc Lapierre, Cathy O. Bull, Ronald E. Savage, Sudharshan Eathiraj, David Vensel, Sapna Makhija, Eugene Kelleher, Neil Westlund, Jeff Szwaya, Yanbin Liu, Steffi Koerner, Magdi Moussa, Susan Cornell-Kennon, Akihisa Matsuda, Darin Kizer, Nivedita Namdev, Hui Wu, Shin Iimura, Brian Schwartz, Erika Volckova
Publikováno v:
Journal of Medicinal Chemistry. 59:6455-6469
The work in this paper describes the optimization of the 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine chemical series as potent, selective allosteric inhibitors of AKT kinases, leading to the discovery of ARQ 092 (21a). The cocrystal str
Autor:
Andrea Haegebarth, William J. Scott, Claudia Schneider, Dean Wilkie, Scott Wilhelm, Paul R. Fracasso, Martin F. Hentemann, Cathy O. Bull, Dominik Mumberg, Ningshu Liu, Bruce R. Rowley, Karl Ziegelbauer, Christoph Schatz
Publikováno v:
Molecular Cancer Therapeutics. 12:2319-2330
Because of the complexity derived from the existence of various phosphoinositide 3-kinase (PI3K) isoforms and their differential roles in cancers, development of PI3K inhibitors with differential pharmacologic and pharmacokinetic profiles would allow
Autor:
William J. Scott, A.M. Bullion, Martin F. Hentemann, E. Sibley, R. Jones, J. Johnson, B. Rowley, A. Redman, Ningshu Liu, Cathy O. Bull
Publikováno v:
European Journal of Cancer Supplements. 8:140
Autor:
Chang-Rung Chen, Jean-Marc Lapierre, Jeffrey D. Szwaya, Yanbin Liu, Nivedita Namdev, Deirdre Lowe, Ron E. Savage, Cathy O. Bull, Thomas C K Chan, Mark A. Ashwell, Dennis S. France
Publikováno v:
Cancer Research. 70:4501-4501
An activating somatic mutation in BRAF kinase (V600E) is found in approximately 70% of melanomas, 50% of papillary thyroid cancers and 10% of colon cancers, fueling interest in BRAF (V600E) as a therapeutic target for cancer treatment. We have previo