Výsledky vyhledávání - "Cathy Michalsky"

Respiratory effects of biased-ligand oliceridine in older volunteers: a pharmacokinetic-pharmacodynamic comparison with morphine

Autor: Pieter Simons, Rutger van der Schrier, Maarten van Lemmen, Simone Jansen, Kiki W.K. Kuijpers, Monique van Velzen, Elise Sarton, Todd Nicklas, Cathy Michalsky, Mark A. Demitrack, Michael Fossler, Erik Olofsen, Marieke Niesters, Albert Dahan

Publikováno v: Anesthesiology.

Background Oliceridine is a G protein–biased µ-opioid, a drug class that is associated with less respiratory depression than nonbiased opioids, such as morphine. The authors quantified the respiratory effects of oliceridine and morphine in elderly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956798915a6ad6c567b96b56eae36242
https://pubmed.ncbi.nlm.nih.gov/36538359

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Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

Autor: Cathy Michalsky, Ashish Khanna, Roderick J. A. Little, Linda Wase, Gregory B. Hammer, Michael J. Fossler, Mark A. Demitrack, Sabry Ayad

Publikováno v: Pain and Therapy

Introduction In the management of postoperative acute moderate-to-severe pain, opioids remain an important component. However, conventional opioids have a narrow therapeutic index and are associated with dose-limiting opioid-related adverse events (O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939a3bcd6fefdd506a72bae6c8c52484
https://doi.org/10.1007/s40122-021-00299-0

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Evaluating the Incidence of Opioid-Induced Respiratory Depression Associated with Oliceridine and Morphine as Measured by the Frequency and Average Cumulative Duration of Dosing Interruption in Patients Treated for Acute Postoperative Pain

Autor: Linda Wase, Mark A. Demitrack, Michael J. Fossler, Sabry Ayad, Ashish Khanna, David A. Burt, Cathy Michalsky

Publikováno v: Clinical Drug Investigation

Background and Objective Opioid-induced respiratory depression (OIRD) is a potentially fatal complication associated with conventional opioids. Currently, there is a paucity of validated endpoints available to measure respiratory safety. Oliceridine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989082f233a053d94e0ee3a28fb92b1b
https://doi.org/10.1007/s40261-020-00936-0

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Low Incidence of Opioid-Induced Respiratory Depression Observed with Oliceridine Regardless of Age or Body Mass Index: Exploratory Analysis from a Phase 3 Open-Label Trial in Postsurgical Pain

Autor: Linda Wase, Ashraf S. Habib, Sergio D. Bergese, Keith A. Candiotti, Cathy Michalsky, Mark A. Demitrack, Peter H. Pan, Michael H. Bourne, Marek Brzezinski, Gregory B. Hammer

Publikováno v: Pain and therapy, vol 10, iss 1

IntroductionAdvanced age and obesity are reported to increase the risk of opioid-induced respiratory depression (OIRD). Oliceridine, an intravenous opioid, is a G-protein-biased agonist at the µ-opioid receptor that may provide improved safety. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d026fb76987fd1614ea1416cded2ca7
https://escholarship.org/uc/item/20w8s92x

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Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

Autor: Cathy Michalsky, Timothy L Beard, Paul Rider, Mark A. Demitrack, Ashraf S. Habib, Michael J. Fossler, Linda Wase, Eugene R. Viscusi, Keith A. Candiotti

Publikováno v: Pain and therapy. 10(1)

Use of parenteral opioids is a major risk factor for postoperative nausea and vomiting. Conventional opioids bind to µ-opioid receptors (MOR), stimulate both the G-protein signaling (achieving analgesia); and the β-arrestin pathway (associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265e6faa2d20a8898f3f38d5ffabc549
https://pubmed.ncbi.nlm.nih.gov/33210266

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