Výsledky vyhledávání - "Cathy McMahan"

A NOVEL BISPECIFIC CD8 TREG MODULATOR TARGETING CYTOLYTIC CD8 REGULATORY T CELLS REDUCES PATHOGENIC CD4 T CELLS AND INFLAMMATION IN TRANSLATIONAL MODELS OF INTESTINAL AUTOIMMUNE AND INFLAMMATORY DISEASE

Autor: Jennifer Gardell, Daniel Boster, Justin Bowser, Courtney Crane, Rachael Fasnacht, Kristin Fitzpatrick, Gleda Hermansky, Susan Julien, Meghan Maurer, Cathy McMahan, Brent Meengs, Dan Patton, Minh Pham, Kristine Swiderek

Publikováno v: Gastroenterology. 164:S15-S16

INTRODUCTION We have characterized a novel CD8 Treg network in autoimmune patient peripheral blood and tissues, in which a subset of cytolytic CD8 Treg eliminate pathogenic CD4 T cells, reducing inflammation and ameliorating disease in response to pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62b4ce6b039c3f2950999f62ea7ba9d
https://doi.org/10.1053/j.gastro.2023.03.038

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Abstract 2380: Preclinical safety and efficacy of a tumor-directed T cell activating 4-1BB x 5T4 ADAPTIR™ bispecific antibody

Autor: Michelle H. Nelson, Anna Dahlman, Starrla Johnson, Cathy McMahan, Adnan Deronic, Peter Ellmark, Gabriele Blahnik-Fagan, Jeannette Bannink, Sara Fritzell, Gabriela Hernandez-Hoyos, Doreen Werchau, Lill Ljung, Robert Bader, Anneli Nilsson, Maria Askmyr

Publikováno v: Cancer Research. 79:2380-2380

The ability to induce potent anti-tumor activity by stimulating 4-1BB (CD137), a key co-stimulatory receptor, makes 4-1BB an attractive immunotherapeutic target. However, a clinically tested, 4-1BB targeting monospecific antibody has been hampered by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aed1f37952c67c77da00ae9e80ab7ee7
https://doi.org/10.1158/1538-7445.am2019-2380

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Activation of the CD137 Pathway in T cells by a CD137 × 5T4 bispecific ADAPTIR Molecule Requires Co-engagement of CD137 and 5T4

Autor: Gabriele R. Blahnik-Fagan, Robert Bader, Jeannette Bannink, Danielle Mitchell, Lynda Misher, Cathy McMahan, David Bienvenue, Sara Fritzell, Anna Säll, Laura von Schantz, Peter Ellmark, Michelle Nelson, Gabriela Hernandez-Hoyos

Publikováno v: The Journal of Immunology. 200:58.21-58.21

CD137 (4-1BB) is a key costimulatory immune receptor (member of the TNFR-superfamily) that is expressed primarily on activated CD8+ T and NK cells. Stimulation of CD137 leads to enhanced proliferation, increased survival, intensified cytolytic activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0be3927d79fa6f33e3277823ebea66b4
https://doi.org/10.4049/jimmunol.200.supp.58.21

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