CD169+ Monocyte and Regulatory T Cell Subsets Are Associated with Disease Activity in Rheumatoid Arthritis

Autor: Amanda J. Eakin, Tahanver Ahmed, Cathy M. McGeough, Stephen Drain, H. Denis Alexander, Gary D. Wright, Philip V. Gardiner, Dawn Small, Anthony J. Bjourson, David S. Gibson

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 11; Pages: 1875
Eakin, A J, Ahmed, T, McGeough, C M, Drain, S, Alexander, H D, Wright, G D, Gardiner, P V, Small, D, Bjourson, A J & Gibson, D S 2022, ' CD169+ monocyte and regulatory T cell subsets are associated with disease activity in rheumatoid arthritis ', Journal of Personalized Medicine, vol. 12, no. 11, 1875 . https://doi.org/10.3390/jpm12111875

Disease activity in rheumatoid arthritis (RA) is influenced by activation of circulating and synovial immune cells. Regulatory T cells (Tregs) and monocytes are key cells that drive inflammation in RA. This study investigated if a relationship exists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e201469e62a73ddc57e753168a1fb21
https://pubmed.ncbi.nlm.nih.gov/36579595

A Novel Processing-Free Method for RNAseq Analysis of Spontaneous Sputum in Chronic Obstructive Pulmonary Disease

Autor: Michele Bassi, Francesca Ricci, Mirco Govoni, Cathy M. McGeough, Gera L. Jellema

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology

Background: Assessments of airways inflammation in patients with chronic obstructive pulmonary disease (COPD) require semi-invasive procedures and specialized sample processing know-how. In this study we aimed to set up and validate a novel non-invas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d29b24ad2e556cc15a3af4b29cc8db
https://www.frontiersin.org/articles/10.3389/fphar.2021.704969/full

Siglec-1 and -2 as potential biomarkers in autoimmune disease

Autor: Michael J. Bustard, Tahanver Ahmed, Cathy M McGeough, Anthony J. Bjourson, Amanda J Eakin, David Gibson

Publikováno v: PROTEOMICS - Clinical Applications. 10:635-644

Autoimmune diseases (ADs) are currently treated with anti-inflammatory and immunosuppressive drugs, aimed at reducing symptoms of disease in order to improve quality of life for patients. However, for a significant number of patients these therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2ad66b5526f7aa988e33d9cb71e651
https://doi.org/10.1002/prca.201500069

Association of baseline cytokine levels with anti-tumour necrosis factor treatment response in rheumatoid arthritis

Autor: David S Gibson, Cathy M McGeough, Mary M Slevin, Gary Wright, Philip Gardiner, Helena A Murray, Mark J Latten, Martin A Crockard, John V Lamont, Anthony J Bjourson

Publikováno v: The Journal of Immunology. 198:201.7-201.7

Background Clinical trials of anti-tumour necrosis factor alpha (TNF) have shown efficacy in 60–70% of rheumatoid arthritis patients (RA). Predicting response to anti-TNF drugs at baseline remains an elusive goal in RA management. The purpose of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2d0def4f5b83ccef6508fd17f3754e8
https://doi.org/10.4049/jimmunol.198.supp.201.7

Diagnostic, Prognostic and Theranostic Biomarkers for Rheumatoid Arthritis

Autor: Cathy M McGeough, Anthony J. Bjourson

Publikováno v: Journal of Clinical & Cellular Immunology.

The identification and adoption of diagnostic and prognostic biomarkers for rheumatoid arthritis has informed and improved the clinical management of this disease. With the advent of biologic treatments such as anti-Tumour Necrosis Factor (anti-TNF)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de6bc5d7fe3bf312b8a25a7fc8b9db69
https://doi.org/10.4172/2155-9899.s6-002