Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Cathy L. Bell-Horner"'
Autor:
Qi Wang, Ren-Qi Huang, Robert H. Mach, Robert R. Luedtke, Glenn H. Dillon, Suwanna Vangveravong, Cathy L. Bell-Horner, Suzy A. Griffin, David E. Reichert, Michelle Taylor, Yogesh Mishra
Publikováno v:
ACS Chemical Neuroscience. 3:1050-1062
We previously reported on the synthesis of substituted phenyl-4-hydroxy-1-piperidyl indole analogues with nanomolar affinity at D2 dopamine receptors, ranging from 10- to 100-fold selective for D2 compared to the D3 dopamine receptor subtype. More re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7e0fdf6da79e7338063c47f0178429
https://doi.org/10.1021/cn300142q
https://doi.org/10.1021/cn300142q
Publikováno v:
Neuroscience Letters. 431:184-189
The presence of phenylalanine (F) at the 6′ position of transmembrane domain 2 (TM2) in the α4 subunit of α4β2 nicotinic receptors enhances desensitization. As the GABA A receptor affords the ability to study the influence of as few as one and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d410fa0b44738d1607916fe99ddcfac
https://doi.org/10.1016/j.neulet.2007.11.039
https://doi.org/10.1016/j.neulet.2007.11.039
Publikováno v:
Journal of Neurobiology. 66:1467-1474
The GABAA receptor is a ligand-gated ion channel whose function and activity can be regulated by ligand binding or alternatively may be influenced indirectly through the phosphorylation of specific subunits that comprise the GABAA receptor pentamer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a00f1118dee17e35b46fa1a0cd10370
https://doi.org/10.1002/neu.20327
https://doi.org/10.1002/neu.20327
Autor:
Douglas F. Covey, Cathy L. Bell-Horner, Eric B. Gonzales, James A. Ferrendelli, Glenn H. Dillon, Maria Antonette M. de la Cruz
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:677-683
Alkyl-substituted butyrolactones have both inhibitory and stimulatory effects on GABA(A) receptors. Lactones with small alkyl substitutions at the alpha-position positively modulate the channel, whereas beta-substituted lactones tend to inhibit the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7089e65d5aaef4ae91e3c705f9a97b56
https://doi.org/10.1124/jpet.103.063008
https://doi.org/10.1124/jpet.103.063008
Autor:
Eric B. Gonzales, Cathy L. Bell-Horner, Ren-Qi Huang, Glenn H. Dillon, A. Raut, Zhenglan Chen, Paromita Das, Douglas F. Covey
Publikováno v:
Neuroscience. 124:195-206
Modulation of type A GABA receptors (GABAA) by L-type Ca++ channel blockers was investigated. The dihydropyridines nifedipine and nitrendipine, and the phenylalkylamine verapamil inhibited recombinant rat alpha1beta2gamma2 receptors recorded from hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb04af874a9743e97da8d24fd7023d0
https://doi.org/10.1016/j.neuroscience.2003.12.005
https://doi.org/10.1016/j.neuroscience.2003.12.005
Publikováno v:
Pharmaceutical Biology. 42:73-82
The ligand-gated anion-selective ion channels are part of a superfamily of ligand-gated ion channels (LGICs) that are responsible for a majority of inhibitory signaling in the central nervous system and are the targets of numerous therapeutics. Aqueo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71fb1f4a3ebab7487e09165b367504b
https://doi.org/10.1080/13880200490505654
https://doi.org/10.1080/13880200490505654
Publikováno v:
Molecular Brain Research. 76:47-55
We have assessed the interaction of picrotoxin and a putative picrotoxin-site ligand [4-dimethyl-3-t-butylcarboxyl-4,5-dihydro (1, 5-a) quinoxaline] (U-93631) with varying configurations of recombinant GABA(A) receptors, using the whole-cell patch cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a817ad9045519fb13f6569ed03ccf8f4
https://doi.org/10.1016/s0169-328x(99)00330-7
https://doi.org/10.1016/s0169-328x(99)00330-7
Autor:
Michael B. Gatch, Michael J. Forster, Cathy L. Bell-Horner, Cynthia M. Taylor, Glenn H. Dillon, Lorie A. Gonzalez
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 329(2)
Carisoprodol is a frequently prescribed muscle relaxant. In recent years, this drug has been increasingly abused. The effects of carisoprodol have been attributed to its metabolite, meprobamate, a controlled substance that produces sedation via GABAA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c851a6255b9927a780a613b29ca8558
https://pubmed.ncbi.nlm.nih.gov/19244096
https://pubmed.ncbi.nlm.nih.gov/19244096
Publikováno v:
Neuroscience letters. 431(2)
The presence of phenylalanine (F) at the 6' position of transmembrane domain 2 (TM2) in the alpha4 subunit of alpha4beta2 nicotinic receptors enhances desensitization. As the GABA A receptor affords the ability to study the influence of as few as one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc9bf315ccca57479f27ec2bdd875901
https://pubmed.ncbi.nlm.nih.gov/18162311
https://pubmed.ncbi.nlm.nih.gov/18162311
Publikováno v:
Neuropharmacology. 44(4)
For a number of years it has been known that the CNS convulsant picrotoxin inhibits the GABA(A) receptor, an anion-selective member of the ligand-gated ion channel (LGIC) superfamily. PTX also inhibits other anion-selective LGIC members, such as GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d8516aafb0eaafda005a02771a04a8
https://pubmed.ncbi.nlm.nih.gov/12646280
https://pubmed.ncbi.nlm.nih.gov/12646280