Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Cathy H Wu"'
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0274042 (2023)
Chinese hamster ovary (CHO) cells are widely used for mass production of therapeutic proteins in the pharmaceutical industry. With the growing need in optimizing the performance of producer CHO cell lines, research on CHO cell line development and bi
Externí odkaz:
https://doaj.org/article/170943bff7464f3d9ed014cb9ef61b47
Autor:
Yuqi Wang, Qinghua Wang, Hongzhan Huang, Wei Huang, Yongxing Chen, Peter B McGarvey, Cathy H Wu, Cecilia N Arighi, UniProt Consortium
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001464 (2021)
The UniProt knowledgebase is a public database for protein sequence and function, covering the tree of life and over 220 million protein entries. Now, the whole community can use a new crowdsourcing annotation system to help scale up UniProt curation
Externí odkaz:
https://doaj.org/article/8fcdc7af40b24f4787b7b816c926098d
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183495 (2017)
Prediction of protein-protein interaction (PPI) remains a central task in systems biology. With more PPIs identified, forming PPI networks, it has become feasible and also imperative to study PPIs at the network level, such as evolutionary analysis o
Externí odkaz:
https://doaj.org/article/e992b4574fcd44c0b2ab56d7998329c4
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 9, p e1004391 (2015)
MicroRNAs (miRNAs) regulate a wide range of cellular and developmental processes through gene expression suppression or mRNA degradation. Experimentally validated miRNA gene targets are often reported in the literature. In this paper, we describe miR
Externí odkaz:
https://doaj.org/article/b7b4a10aa6004ae586473d7a7592ddd7
Autor:
Christopher W Resnyk, Chuming Chen, Hongzhan Huang, Cathy H Wu, Jean Simon, Elisabeth Le Bihan-Duval, Michel J Duclos, Larry A Cogburn
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139549 (2015)
Genetic selection for enhanced growth rate in meat-type chickens (Gallus domesticus) is usually accompanied by excessive adiposity, which has negative impacts on both feed efficiency and carcass quality. Enhanced visceral fatness and several unique f
Externí odkaz:
https://doaj.org/article/82cd7323aa8b491f91c75ae9a1f35ddc
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141773 (2015)
Given the wealth of bioinformatics resources and the growing complexity of biological information, it is valuable to integrate data from disparate sources to gain insight into the role of genes/proteins in health and disease. We have developed a bioi
Externí odkaz:
https://doaj.org/article/cc0a8510483b4ebbacbba11812bb0f97
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135305 (2015)
Automatically detecting gene/protein names in the literature and connecting them to databases records, also known as gene normalization, provides a means to structure the information buried in free-text literature. Gene normalization is critical for
Externí odkaz:
https://doaj.org/article/a1581755afec4497b96b9f7c059f81a3
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
As a member of the Open Biomedical Ontologies (OBO) foundry, the Protein Ontology (PRO) provides an ontological representation of protein forms and complexes and their relationships. Annotations in PRO can be assigned to individual protein forms and
Externí odkaz:
https://doaj.org/article/4a209def28a449ed9d472c07bd0e8572
Autor:
Chuming Chen, Darren A Natale, Robert D Finn, Hongzhan Huang, Jian Zhang, Cathy H Wu, Raja Mazumder
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18910 (2011)
The accelerating growth in the number of protein sequences taxes both the computational and manual resources needed to analyze them. One approach to dealing with this problem is to minimize the number of proteins subjected to such analysis in a way t
Externí odkaz:
https://doaj.org/article/91325256431f471fb895dc45c1093642
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11604 (2010)
Members of the Roseobacter clade which play a key role in the biogeochemical cycles of the ocean are diverse and abundant, comprising 10-25% of the bacterioplankton in most marine surface waters. The rapid accumulation of whole-genome sequence data f
Externí odkaz:
https://doaj.org/article/218754794a2448a9829e6ebcc2f7f6ff