Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cathy E. Richards"'
Autor:
Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E. Richards, Hanne Jahns, Maïté Verreault, Franck Bielle, Ahmed Idbaih, Martine L. M. Lamfers, Ann M. Hopkins, Markus Rehm, Brona M. Murphy
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Activation of cyclin-dependent kinases (CDKs) contributes to the uncontrolled proliferation of tumour cells. Genomic alterations that lead to the constitutive activation or overexpression of CDKs can support tumourigenesis including glioblas
Externí odkaz:
https://doaj.org/article/e570565c5c9e4aba8f436575ecc4c3ff
Autor:
Cathy E. Richards, Yasir Y. Elamin, Aoife Carr, Kathy Gately, Shereen Rafee, Mattia Cremona, Emer Hanrahan, Robert Smyth, Daniel Ryan, Ross K. Morgan, Susan Kennedy, Lance Hudson, Joanna Fay, Kenneth O’Byrne, Bryan T. Hennessy, Sinead Toomey
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10545 (2023)
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the
Externí odkaz:
https://doaj.org/article/6dfb1fbd27d14df4ba344828c1f6dcc5
Autor:
Toomey, Cathy E. Richards, Yasir Y. Elamin, Aoife Carr, Kathy Gately, Shereen Rafee, Mattia Cremona, Emer Hanrahan, Robert Smyth, Daniel Ryan, Ross K. Morgan, Susan Kennedy, Lance Hudson, Joanna Fay, Kenneth O’Byrne, Bryan T. Hennessy, Sinead
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10545
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the
Autor:
Elaine W. Kay, Anthony O'Grady, David Borg, Katherine M. Sheehan, Joanna Fay, Arnold D.K. Hill, Ann M. Hopkins, Karin Jirström, Cathy E. Richards, Charlotta Hedner
Publikováno v:
Cancers, Vol 13, Iss 1286, p 1286 (2021)
Cancers
Volume 13
Issue 6
Cancers
Volume 13
Issue 6
Simple Summary High levels of the protein Junctional Adhesion Molecule-A (JAM-A) have been linked with aggressive disease in patients with several different cancers. However, its distribution is often non-uniform (heterogeneous) across tumors, and ca
Publikováno v:
British Journal of Surgery. 108
Introduction Junctional Adhesion Molecule-A (JAM-A) has important physiological functions in epithelial and endothelial barriers, but its overexpression has also been linked with tumour progression and poor prognosis in various malignancies. Since JA
Autor:
Lance Hudson, Naoimh O’Farrell, Stephen F. Madden, Hanne Jahns, Katherine M. Sheehan, Ann M. Hopkins, Joanna Fay, Karin Jirström, Kieran Brennan, Rodrigo G.B. Cruz, Cathy E. Richards, Sri HariKrishna Vellanki
Publikováno v:
Cancers
Cancers, Vol 13, Iss 871, p 871 (2021)
Volume 13
Issue 4
Cancers, Vol 13, Iss 871, p 871 (2021)
Volume 13
Issue 4
The success of breast cancer therapies targeting the human epidermal growth factor receptor-2 (HER2) is limited by the development of drug resistance by mechanisms including upregulation of HER3. Having reported that HER2 expression and resistance to
Autor:
Joanna Fay, Lance Hudson, Brona M. Murphy, Viktorija Juric, Markus Rehm, Ann M Hopkins, Maite Verreault, Martine L.M. Lamfers, Cathy E Richards, Franck Bielle, Hanne Jahns, Ahmed Idbaih
Publikováno v:
Cell Death & Disease
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2021, 12 (8), pp.763. ⟨10.1038/s41419-021-04050-7⟩
Cell Death and Disease, 2021, 12 (8), pp.763. ⟨10.1038/s41419-021-04050-7⟩
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death and Disease, 12(8):763. Nature Publishing Group
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2021, 12 (8), pp.763. ⟨10.1038/s41419-021-04050-7⟩
Cell Death and Disease, 2021, 12 (8), pp.763. ⟨10.1038/s41419-021-04050-7⟩
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death and Disease, 12(8):763. Nature Publishing Group
Activation of cyclin-dependent kinases (CDKs) contributes to the uncontrolled proliferation of tumour cells. Genomic alterations that lead to the constitutive activation or overexpression of CDKs can support tumourigenesis including glioblastoma (GBM
Autor:
Yvonne E. Smith, Guannan Wang, Ciara L. Flynn, Stephen F. Madden, Owen MacEneaney, Rodrigo G. B. Cruz, Cathy E. Richards, Hanne Jahns, Marian Brennan, Mattia Cremona, Bryan T. Hennessy, Katherine Sheehan, Alexander Casucci, Faizah A. Sani, Lance Hudson, Joanna Fay, Sri H. Vellanki, Siobhan O’Flaherty, Marc Devocelle, Arnold D. K. Hill, Kieran Brennan, Saraswati Sukumar, Ann M. Hopkins
Publikováno v:
Cancers; Volume 14; Issue 5; Pages: 1303
Breast ductal carcinoma in situ (DCIS) is clinically challenging, featuring high diagnosis rates and few targeted therapies. Expression/signaling from junctional adhesion molecule-A (JAM-A) has been linked to poor prognosis in invasive breast cancers
Publikováno v:
Cellular Oncology. 41:35-46
Triple-negative breast cancers (TNBC) lack expression of three common cell surface receptors, i.e., estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Accordingly, TNBCs are associated with fewer t
Publikováno v:
Oncotarget