Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Cathy D. Moore"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3710-3713
Recent discoveries of important pharmacological properties have drawn attention to the reactivity of HNO (azanone, nitroxyl) with biologically relevant substrates. Apart from its role in thiol oxidation, HNO has been reported to have nitrosative prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525e9f68f2ea4d9c2aa1dea5b80c5dbe
https://doi.org/10.1016/j.bmcl.2014.07.014
https://doi.org/10.1016/j.bmcl.2014.07.014
Autor:
Edward I. Solomon, Kenneth D. Karlin, Shunichi Fukuzumi, Cathy D. Moore, Jung Yoon Lee, Isaac Garcia-Bosch, Kei Ohkubo, Richard A. Himes, Julia S. Woertink, Ryan L. Peterson
Publikováno v:
Journal of the American Chemical Society
To obtain mechanistic insights into the inherent reactivity patterns for copper(I)-O2 adducts, a new cupric-superoxo complex [(DMM-tmpa)Cu(II)(O2(•-))](+) (2) [DMM-tmpa = tris((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)amine] has been synthesized a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b267f12fcb3059fb90a04a120b1030c
http://europepmc.org/articles/PMC4102632
http://europepmc.org/articles/PMC4102632
Autor:
Britt Hedman, Keith O. Hodgson, Ryan E. Cowley, Shunichi Fukuzumi, Ryan L. Peterson, Richard A. Himes, Edward I. Solomon, Munzarin F. Qayyum, Maxime A. Siegler, Jake W. Ginsbach, Kenneth D. Karlin, Cathy D. Moore
Publikováno v:
Journal of the American Chemical Society. 135:16454-16467
The protonation–reduction of a dioxygen adduct with [LCu(I)][B(C6F5)4], cupric superoxo complex [LCu(II)(O2(•–))]+ (1) (L = TMG3tren (1,1,1-tris[2-[N(2)-(1,1,3,3-tetramethylguanidino)]ethyl]amine)) has been investigated. Trifluoroacetic acid (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5051da5a3022a567c11478ad1c9e7dc8
https://doi.org/10.1021/ja4065377
https://doi.org/10.1021/ja4065377
Publikováno v:
Journal of the American Chemical Society. 134:1962-1965
Due to its inherent reactivity, nitroxyl (HNO), must be generated in situ through the use of donor compounds, but very few physiologically useful HNO donors exist. Novel N-substituted hydroxylamines with carbon-based leaving groups have been synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34709b0c2b3b60ba3b0e5707ccaba4b8
https://doi.org/10.1021/ja2103923
https://doi.org/10.1021/ja2103923
Autor:
Haihong Wu, Ben Bolaños, Nowlin Dawn Marie, Simon Bergqvist, Cathy D. Moore, T.A. Pauly, Alexei Brooun
Publikováno v:
Chemical Biology & Drug Design. 74:212-223
Previous reports describe modulators of X-linked inhibitor of apoptosis (XIAP)-caspase interaction designed from the AVPI N-terminal peptide sequence of second mitochondria-derived activator of caspase. A fragment-based drug design strategy was initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38684fb56e7f30abfb6b65242495df14
https://doi.org/10.1111/j.1747-0285.2009.00862.x
https://doi.org/10.1111/j.1747-0285.2009.00862.x
Publikováno v:
Medical Care. 37:1092-1104
Background. Minority persons have less access to many specialty treatments and services, possibly because of clinician biases. It is not clear whether any such biases exist in primary care settings, especially for children with psychosocial problems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35f14321f20e86f3dbbbed2de824f36
https://doi.org/10.1097/00005650-199911000-00002
https://doi.org/10.1097/00005650-199911000-00002
Autor:
Bryan T. Mott, Gary H. Posner, Cathy D. Moore, Abhai K. Tripathi, David J. Sullivan, Maxime A. Siegler
Publikováno v:
Journal of medicinal chemistry. 56(6)
Malaria continues to be a difficult disease to eradicate, largely due to the widespread populations it affects and to the resistance that malaria parasites have developed against once very potent therapies. The natural product artemisinin has been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fdc50b9faf6b15063f6b9f23032318
https://pubmed.ncbi.nlm.nih.gov/23425037
https://pubmed.ncbi.nlm.nih.gov/23425037
Autor:
Cathy D. Moore, Gerald D. Fasman
Publikováno v:
Proceedings of the National Academy of Sciences. 91:11232-11235
Neurofibrillary tangles are one of two lesions found in the brain of Alzheimer disease victims. With synthetic peptide fragments of human neurofilament NF-M17 (Glu-Glu-Lys-Gly-Lys-Ser-Pro- Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly, phosphorylated and u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641630560b333fae73c813756d2bab06
https://doi.org/10.1073/pnas.91.23.11232
https://doi.org/10.1073/pnas.91.23.11232
Autor:
Cathy D. Moore, Juliette T. J. Lecomte
Publikováno v:
Biochemistry. 29:1984-1989
Upon removal of the heme group, the water-soluble fragment of cytochrome b5 adopts a conformation less stable and compact than that of the holoprotein [Huntley, T. E., & Strittmatter, P. (1972) J. Biol. Chem. 247, 4641-4647]. This conformation, impos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff5426b00e66525b90f414982022111
https://doi.org/10.1021/bi00460a004
https://doi.org/10.1021/bi00460a004
Backbone 1H, 13C, and 15N resonance assignments for the 21 kDa GTPase Rac1 complexed to GDP and Mg2+
Publikováno v:
Journal of biomolecular NMR. 27(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ac1372a492dc3c1b11c6b8a53562c7b
https://pubmed.ncbi.nlm.nih.gov/12878844
https://pubmed.ncbi.nlm.nih.gov/12878844