Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cathy D Spillane"'
Autor:
Mark Bates, Cathy D Spillane, Michael F Gallagher, Amanda McCann, Cara Martin, Gordon Blackshields, Helen Keegan, Luke Gubbins, Robert Brooks, Doug Brooks, Stavros Selemidis, Sharon O'Toole, John J O'Leary
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243715 (2020)
Despite the use of front-line anticancer drugs such as paclitaxel for ovarian cancer treatment, mortality rates have remained almost unchanged for the past three decades and the majority of patients will develop recurrent chemoresistant disease which
Externí odkaz:
https://doaj.org/article/1b4173fb417c4b46a697ca0c7cfb267a
Autor:
Charles J d'Adhemar, Cathy D Spillane, Michael F Gallagher, Mark Bates, Katie M Costello, Jacqui Barry-O'Crowley, Kathryn Haley, Niamh Kernan, Ciara Murphy, Paul C Smyth, Ken O'Byrne, Stephen Pennington, Aoife A Cooke, Brendan Ffrench, Cara M Martin, Dearbhaile O'Donnell, Bryan Hennessy, Britta Stordal, Stephen Finn, Amanda McCann, Noreen Gleeson, Tom D'Arcy, Brian Flood, Luke A J O'Neill, Orla Sheils, Sharon O'Toole, John J O'Leary
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100816 (2014)
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistan
Externí odkaz:
https://doaj.org/article/208a05f77739491a8afed939f68cee69
Autor:
Cathy D. Spillane, Amanda McCann, Luke Gubbins, Stavros Selemidis, Doug A. Brooks, Robert Darren Brooks, John J. O'Leary, Mark Bates, Helen Keegan, Cara Martin, Sharon O'Toole, Gordon Blackshields, Michael Gallagher
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243715 (2020)
PLoS ONE
PLoS ONE
Despite the use of front-line anticancer drugs such as paclitaxel for ovarian cancer treatment, mortality rates have remained almost unchanged for the past three decades and the majority of patients will develop recurrent chemoresistant disease which
Autor:
Yanmei Huang, Nathan Brady, Orla Sheils, Jessica K. Heatlie, Sharon O'Toole, Lucy A. Norris, John J. O'Leary, Cathy D. Spillane, Robert Darren Brooks, Gordon Blackshields, Aoife L Canney, Mark Ward, Cara Martin, Bashir M. Mohamed, Andres Clarke, Eric P. Dixon, Paul Smyth, Mark Bates, Sean Hanniffy, Michael Gallagher, Stavros Selemidis, Niamh M. Cooke, Tanya Kelly, Sinead Skehan, Dermot Kenny, Doug A. Brooks
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 12, Pp 101229-(2021)
Translational Oncology, Vol 14, Iss 12, Pp 101229-(2021)
Highlights • Platelet cancer cell interactions are a key factor in driving the pro-metastatic phenotype. • Platelet cancer cell interactions appear to be mediated by 5 key genes which have established roles in metastasis. • Targeting these medi
Autor:
Orla Sheils, Amanda McCann, Lynda McEvoy, Michael F Gallagher, Noreen Gleeson, John J. O'Leary, Britta K. Stordal, Lucy A. Norris, Cathy D Spillane, Sharon O'Toole, Fiona Furlong, Cara Martin, Aloysius McGoldrick
Publikováno v:
Laboratory Investigation. 93:523-552
Publikováno v:
BMC Cancer
Background Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metas
Autor:
Michael F Gallagher, Paul Smyth, Yvonne M Salley, John J. O'Leary, Cathy D Spillane, Gordon Blacksheilds, William Watson, Brendan Ffrench, Cara Martin, Orla Sheils, Salah El Baruni
Publikováno v:
Journal of clinical pathology. 68(9)
AimsTargeting the stem cell properties of tumor-initiating cells is an avenue through which cancer treatment may be improved. Before this can be achieved, so-called ‘cancer stem cell’ (CSC) models must be developed and characterized in specific m
Autor:
John J. O'Leary, Dearbhaile M. O'Donnell, Sharon O'Toole, Luke A. J. O'Neill, Amanda McCann, Brian Flood, Kathryn Haley, Noreen Gleeson, Ciara Murphy, Bryan T. Hennessy, Stephen P. Finn, Stephen R. Pennington, Cathy D. Spillane, Michael F Gallagher, Britta K. Stordal, Cara Martin, Aoife A. Cooke, Kenneth J. O'Byrne, Orla Sheils, Mark Bates, Brendan Ffrench, Katie M. Costello, Niamh Kernan, Jacqui Barry-O'Crowley, Tom D'Arcy, Charles d’Adhemar, Paul Smyth
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100816 (2014)
PLoS ONE
PLoS ONE
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistan
Autor:
Peter Koltay, Azmi Yusof, Orla Sheils, Cara Martin, John J. O'Leary, Roland Zengerle, Helen Keegan, Cathy D. Spillane
Publikováno v:
Lab on a Chip
Cell sorting and separation techniques are essential tools for cell biology research and for many diagnostic and therapeutic applications. For many of these applications, it is imperative that heterogeneous populations of cells are segregated accordi
Autor:
John J. O'Leary, Orla Sheils, Sharon O'Toole, Michael F Gallagher, Salah A Elbaruni, Alexandros Laios, Cynthia C B B Heffron, Paul Smyth, Cathy D Spillane, Brendan Ffrench, Cara Martin, Richard Flavin
Publikováno v:
Journal of Ovarian Research, Vol 5, Iss 1, p 2 (2012)
Journal of Ovarian Research
Journal of Ovarian Research
Background Malignant ovarian disease is characterised by high rates of mortality due to high rates of recurrent chemoresistant disease. Anecdotal evidence indicates this may be due to chemoresistant properties of cancer stem cells (CSCs). However, ou