In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair

Autor: Stefan Peissert, Florian Sauer, Daniel B. Grabarczyk, Cathy Braun, Gudrun Sander, Arnaud Poterszman, Jean-Marc Egly, Jochen Kuper, Caroline Kisker

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

XPD is part of the TFIIH complex which plays major roles in transcription initiation and nucleotide excision repair (NER). Here the authors present a high-resolution crystal structure of the XPD-MAT1 interface and dissect the role of this interface i

Externí odkaz: https://doaj.org/article/52a2dac0f1f34c4a966c28ea3af6e495

In TFIIH, XPD helicase is exclusively devoted to DNA repair.

Autor: Jochen Kuper, Cathy Braun, Agnes Elias, Gudrun Michels, Florian Sauer, Dominik R Schmitt, Arnaud Poterszman, Jean-Marc Egly, Caroline Kisker

Publikováno v: PLoS Biology, Vol 12, Iss 9, p e1001954 (2014)

The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome,

Externí odkaz: https://doaj.org/article/88cc70ed5c364099a3152604a61d9dd6

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

Autor: Jérémy Sandoz, Max Cigrang, Philippe Catez, Lise-Marie Donnio, Clèmence Elly, Pietro Berico, Cathy Braun, Sergey Alekseev, Jean-Marc Egly, Guiseppina Mari-Giglia, Emmanuel Compe, Frédéric Coin

The transcriptional response to genotoxic stress involves gene expression arrest, followed by recovery of mRNA synthesis (RRS) after DNA repair. Using a small-scale RNA interference screen, we found that the lack of the EXD2 nuclease impaired RRS and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f6dd5ba4fe8e672a10c1ffee28fe475
https://doi.org/10.1101/2022.07.20.499545

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH

Autor: Jochen Kuper, Jean M. Egly, Cathy Braun, Laura Radu, Arnaud Poterszman, Dominik Schmitt, Sarah Cianférani, Caroline Kisker, Julien Marcoux, Elisabeth Schoenwetter, W. Koelmel

Publikováno v: 'Nucleic Acids Research ', vol: 45, pages: 10872-10883 (2017)
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (18), pp.10872-10883. ⟨10.1093/nar/gkx743⟩

The general transcription factor IIH (TFIIH) is a multi-protein complex and its 10 subunits are engaged in an intricate protein–protein interaction network critical for the regulation of its transcription and DNA repair activities that are so far l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c95869213115c31ed113f2842bcb37
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:48193

ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities

Autor: Izarn Iltis, Anne Maglott-Roth, Christophe Giraudon, Cathy Braun, Jean-Marc Egly, Wassim Abdulrahman, Laura Radu, Arnaud Poterszman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (8), ⟨10.1073/pnas.1213981110⟩
Proceedings of the National Academy of Sciences

International audience; The xeroderma pigmentosum group D (XPD) helicase is a subunit of transcription/DNA repair factor, transcription factor II H (TFIIH) that catalyzes the unwinding of a damaged DNA duplex during nucleotide excision repair. Apart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22043e5eed93718df799e4bca33d98a5
https://doi.org/10.1073/pnas.1213981110