Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cathryn Weston"'
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77487 (2013)
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42. Schizosaccharomy
Externí odkaz:
https://doaj.org/article/b9039beb575140809d209e6448c4b8f4
Autor:
Michael Biddle, Dawn T. Smallwood, E Castells, Peter Bradding, Katy M. Roach, Cathryn Weston, Yassine Amrani, Viona W. Bowman, Harvinder Virk, Jamie McCarthy, S. Mark Duffy
Publikováno v:
British Journal of Pharmacology. 178:2948-2962
BACKGROUND AND PURPOSE TGFβ1-mediated myofibroblast activation contributes to pathological fibrosis in many diseases including idiopathic pulmonary fibrosis (IPF), where myofibroblast resistance to oxidant-mediated apoptosis is also evident. We ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0db6341e9b5fd4c470815fca25d68c
https://doi.org/10.1111/bph.15467
https://doi.org/10.1111/bph.15467
Autor:
Adam K. A. Wright, Latifa Chachi, Katy M. Roach, Peter Bradding, J. Sousa, Michael Biddle, Cathryn Weston, Harvinder Virk, M. Z. Rekas
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
The transient receptor potential cation channel family member ankyrin 1 (TRPA1) is a potential target for several diseases, but detection of human TRPA1 (hTRPA1) protein in cells and tissues is problematic as rigorous antibody validation is lacking.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7227276209bc4fa5d5c76046735f9b8
https://pubmed.ncbi.nlm.nih.gov/31811235
https://pubmed.ncbi.nlm.nih.gov/31811235
Autor:
David J. Cousins, Cathryn Weston
Publikováno v:
eLS
Innate lymphoid cells (ILCs) are white blood cells derived from a common progenitor in the bone marrow. They respond rapidly to a limited array of antigens at the site of infection to provide immediate protection. The first identified ILCs were natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38d24e39c9630c9967e3310900ed04b5
https://doi.org/10.1002/9780470015902.a0026245
https://doi.org/10.1002/9780470015902.a0026245
Autor:
Kerry Barkan, David J. Roberts, Gary B. Willars, Naichang Li, Jing Lu, Timothy M. Skerry, Simon J. Dowell, Christopher A. Reynolds, Meenakshi Pardamwar, Graham Ladds, Gareth O. Richards, David R. Poyner, Cathryn Weston
Publikováno v:
The Journal of Biological Chemistry
Background: The glucagon and glucagon-like peptide-1 (GLP-1) receptors are important targets for treating type 2 diabetes. Results: We describe novel glucagon receptor pharmacology, through interaction with the receptor activity-modifying protein-2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d90ab0a5f6fbda85c2c5df2381a79c
https://doi.org/10.1074/jbc.m114.624601
https://doi.org/10.1074/jbc.m114.624601
Autor:
Ann M. Dixon, Antonia Lock, Leo Bowsher, Rachel Forfar, Graham Ladds, Cathryn Weston, Graham J. G. Upton, Christopher A. Reynolds
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1838(12):3036-3051
G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors in mammals and facilitate a range of physiological responses triggered by a variety of ligands. GPCRs were thought to function as monomers, however it is now accepte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec53cbb824cd62fbcafa4c7ba92ca36
Autor:
Simon J. Dowell, Cathryn Weston, Harriet A. Watkins, Graham Ladds, Ian Winfield, Rose Hodgson, Archna Shah, David R. Poyner, David A. Woodcock, Juan Carlos Mobarec, Matthew J. Harris, Christopher A. Reynolds
Publikováno v:
The Journal of Biological Chemistry
The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three receptor activity-modifying proteins (RAMPs). Binding of one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d24ed56caf4393db55fbd6a5336e31
https://www.repository.cam.ac.uk/handle/1810/260854
https://www.repository.cam.ac.uk/handle/1810/260854
Autor:
Adam K A, Wright, Cathryn, Weston, Batika M J, Rana, Christopher E, Brightling, David J, Cousins
Publikováno v:
The Journal of Allergy and Clinical Immunology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::444f504e331565e4bc07cc179ff8cfb3
https://pubmed.ncbi.nlm.nih.gov/28502824
https://pubmed.ncbi.nlm.nih.gov/28502824
Autor:
Makoto Shigeto, Manuela Zaccolo, Reshma Ramracheya, Antony Galione, William Sones, Thomas Reinbothe, Benoit Hastoy, Rudi Vennekens, Elisa Vergari, Cathryn Weston, Graham Ladds, Viacheslav O. Nikolaev, Chae Young Cha, Masashi Katsura, Nils J.G. Rorsman, Andrei I. Tarasov, Patrik Rorsman, Paul Johnson, Julia Gorelik, Koenraad Philippaert, Margarita V. Chibalina, Albert Salehi, Kohei Kaku
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce9c8d589f091227aa5ae7d0286bf35
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79
Autor:
Emma J, Prokic, Cathryn, Weston, Naoki, Yamawaki, Stephen D, Hall, Roland S G, Jones, Ian M, Stanford, Graham, Ladds, Gavin L, Woodhall
Publikováno v:
Neuropharmacology. 95
Tonic conductance mediated by extrasynaptic GABAA receptors has been implicated in the modulation of network oscillatory activity. Using an in vitro brain slice to produce oscillatory activity and a kinetic model of GABAA receptor dynamics, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c76cbb426ec9ee044650ff4f0b495f5f
https://pubmed.ncbi.nlm.nih.gov/25797493
https://pubmed.ncbi.nlm.nih.gov/25797493