Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cathryn R, Formichella"'
Autor:
Lauren K. Wareham, Franklin D. Echevarria, Jennifer L. Sousa, Danielle O. Konlian, Gabrielle Dallas, Cathryn R. Formichella, Priya Sankaran, Peter J. Goralski, Jenna R. Gustafson, Rebecca M. Sappington
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103141- (2021)
Summary: The interleukin-6 (IL-6) family of cytokines and its downstream effector, STAT3, are important mediators of neuronal health, repair, and disease throughout the CNS, including the visual system. Here, we elucidate a transcription-independent
Externí odkaz:
https://doaj.org/article/b63bd7395b34419184036396f2f520ab
Autor:
D’Anne S. Duncan, Rebecca L. Weiner, Carl Weitlauf, Michael L. Risner, Abigail L. Roux, Emily R. Sanford, Cathryn R. Formichella, Rebecca M. Sappington
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The β-chemokine Ccl5 and its receptors are constitutively expressed in neurons of the murine inner retina. Here, we examined the functional and structural significance of this constitutive Ccl5 signaling on retinal development. We compared outcomes
Externí odkaz:
https://doaj.org/article/a1397087d9aa4a4a9073b02de6dbb374
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
The pleotropic cytokine interleukin-6 (IL-6) is implicated in retinal ganglion cell (RGC) survival and degeneration, including that associated with glaucoma. IL-6 protects RGCs from pressure-induced apoptosis in vitro. However, it is unknown how IL-6
Externí odkaz:
https://doaj.org/article/8429ffbdd5204f1696c0a3283d203570
Autor:
Priya Sankaran, Jenna R. Gustafson, Peter J. Goralski, Lauren K. Wareham, Danielle O. Konlian, Cathryn R. Formichella, Rebecca M. Sappington, Gabrielle Dallas, Franklin D. Echevarria, Jennifer L. Sousa
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103141-(2021)
iScience
iScience
Summary The interleukin-6 (IL-6) family of cytokines and its downstream effector, STAT3, are important mediators of neuronal health, repair, and disease throughout the CNS, including the visual system. Here, we elucidate a transcription-independent m
Autor:
David J. Calkins, Silvia Pasini, John W. Collyer, Wendi S. Lambert, Brian J. Carlson, Cathryn R. Formichella, Purnima Ghose
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Glaucoma is a group of optic neuropathies associated with aging and sensitivity to intraocular pressure (IOP). Early progression involves retinal ganglion cell (RGC) axon dysfunction that precedes frank degeneration. Previously we demonstrated that p
Autor:
David J, Calkins, Wendi S, Lambert, Cathryn R, Formichella, William M, McLaughlin, Rebecca M, Sappington
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1695
Glaucoma is a common optic neuropathy that leads to vision loss through the degeneration of retinal ganglion cells (RGCs) and their axons. RGC degeneration in glaucoma is associated with sensitivity to intraocular pressure (IOP) and elevated IOP (als
Autor:
David J. Calkins, Rebecca M. Sappington, Wendi S. Lambert, William M. McLaughlin, Cathryn R. Formichella
Publikováno v:
Glaucoma ISBN: 9781493974061
Glaucoma is a common optic neuropathy that leads to vision loss through the degeneration of retinal ganglion cells (RGCs) and their axons. RGC degeneration in glaucoma is associated with sensitivity to intraocular pressure (IOP) and elevated IOP (als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d383de0d482713505f1022044f95d2
https://doi.org/10.1007/978-1-4939-7407-8_3
https://doi.org/10.1007/978-1-4939-7407-8_3
Autor:
Rebecca M. Sappington, Noah Vasilakes, William M. McLaughlin, D’Anne S. Duncan, Cathryn R. Formichella, Franklin D. Echevarria
Publikováno v:
Journal of clinical & cellular immunology
Signaling by inflammatory cytokines and chemokines is associated with neurodegeneration in disease and injury. Here we examined expression of the β-chemokine CCL5 and its receptors in the mouse retina and evaluated its relevance in glaucoma, a commo
Autor:
Rebecca M. Sappington, Stephanie M Sims, Simone K Abella, Heather M. Cathcart, Cathryn R. Formichella
Publikováno v:
Journal of clinical & cellular immunology
Retinal ganglion cell (RGC) loss in glaucoma is sectorial in nature and preceded by deficits in axonal transport. Neuroinflammation plays an important role in the pathophysiology of glaucoma in the retina, optic nerve and visual centers of the brain,